Faecal calprotectin in differentiating between functional and organic bowel diseases

Elbadry, Ahmed; Sedrak, Heba; Rashed, Layla

doi:10.1016/j.ajg.2010.04.009

Cited by 12 publications

(35 citation statements)

References 26 publications

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“…We included seven studies 60,73,75,77,81,83,88 in this group, shown in the paired forest plots below (see Figure 3). One of these studies (Basumani et al 83 and P Basumani, Rotherham Hospital, 2012, personal communication)…”

Section: Results Of Clinical Effectiveness Reviewmentioning

confidence: 99%

“…In some studies, the ranges do not overlap, whereas in others they do. For example, in El-Badry et al, 81 the value of FC in patients with IBD ranged between 98 and 637 µg/g, which does not overlap with the value of FC in patients with IBS (14-65 µg/g). In all other studies, the range of FC in patients with IBD overlapped with the range of FC in patients with IBS.…”

Section: Rangesmentioning

confidence: 99%

“…These are based on five studies. 60,73,75,81,83 There was only one study for the 100 µg/g cut-off. 73 With an AUC of 0.97 at 50 µg/g, there is little room for improvement.…”

Section: Specificity (95% Ci)mentioning

confidence: 99%

See 2 more Smart Citations

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Waugh

Cummins²,

Royle³

et al. 2013

Health Technology Assessment

234

201

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Section: Results Of Clinical Effectiveness Reviewmentioning

confidence: 99%

Section: Rangesmentioning

confidence: 99%

See 1 more Smart Citation

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Waugh

Cummins²,

Royle³

et al. 2013

Health Technology Assessment

234

201

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“…Endoscopy with biopsy is the gold standard diagnostic tool for the assessment of chronic gastrointestinal disorders, but it is an invasive procedure and does not show the entire digestive tract. Thus, a simple marker, with high sensitivity and specificity, inexpensive and noninvasive such as calprotectin is essential for diagnosis and monitoring any inflammation of the digestive system (4,5). Some studies suggest that the level of fecal calprotectin is a good diagnostic marker to distinguish between organic and functional disorders (6).…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Fecal Calprotectin and Upper Endoscopy Findings in Children With Upper Gastrointestinal Symptoms

et al. 2017

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Background: Chronic abdominal pain in children is a common disorder. For an accurate diagnosis of its cause, sometimes invasive diagnostic procedures such as endoscopy should be performed. Objectives: The purpose of the study was to evaluate the fecal calprotectin in children with upper gastrointestinal signs and symptoms and to compare it with endoscopic findings. Methods: A total of 131 children aged 1-14 years with upper gastrointestinal symptoms were enrolled during 2012 -2013 at two centers. One hundred and twenty patients underwent endoscopy and biopsy. Before endoscopy, the level of calprotectin was measured by the enzyme-linked immunosorbent assay test in stool samples and the results were compared with the endoscopic and pathology findings. Results: Of the 120 children included in this study, 71 (59.2%) were males and 49 (40.8%) females with a mean age of 93.6 months. Of the 112 patients in whom biopsies were taken, 16 had esophagitis, 89 chronic gastritis (79.5%) and 57 colonization with Helicobacter pylori. Conclusions: There was a statistically significant correlation between fecal calprotectin and gastritis and severity of H. pylori infection. Fecal calprotectin level measurement can avoid unnecessary endoscopies and is also useful for evaluation of therapy response.

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“…An analysis of gut lavage fluid using chromatographic techniques has also shown that mucin levels differ between samples from healthy and IBD subjects [2]. Faecal calprotectin levels in faeces have been proposed as a marker for intestinal inflammation [3,4]. In spite of these studies, the gut environment is still poorly investigated, and this fundamental limitation, in turn, leads to difficulty in understanding the causes and behaviour of diseases of the gut.…”

mentioning

confidence: 99%

Characterization of the Electrochemical Behavior of Gastrointestinal Fluids Using a Multielectrode Sensor Probe

Twomey

Eulate

Marchesi

et al. 2011

IEEE Trans. Biomed. Eng.

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Faecal calprotectin in differentiating between functional and organic bowel diseases

Cited by 12 publications

References 26 publications

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Relationship Between Fecal Calprotectin and Upper Endoscopy Findings in Children With Upper Gastrointestinal Symptoms

Characterization of the Electrochemical Behavior of Gastrointestinal Fluids Using a Multielectrode Sensor Probe

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