Factors That May Influence Estimated Glomerular Filtration Rate in Patients With Excellent Graft Function 10 Years Posttransplant

Guerra, J.; Raimundo, Mário; Teixeira, Catarina; Santana, Alice; Cortesão, A.; Costa, António Gomes da

doi:10.1016/j.transproceed.2013.03.003

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Mezrich et al [83] have recently reported that elderly patients over 60 years of age with kidneys transplanted from cadaveric marginal donors have a -year shorter patient and graft survival expectancy than that of elderly recipients of standard criteria donors. A similar analysis with 117 patients transplanted from deceased donors indicated a direct correlation between donor age and graft function at 10 years after renal transplantation [84].…”

Section: Cadaveric Marginal Donorsmentioning

confidence: 71%

Marginal Donors in Renal Transplantation

Bozkurt

Kılıç

2015

Transplantation Proceedings

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Section: Cadaveric Marginal Donorsmentioning

confidence: 71%

Marginal Donors in Renal Transplantation

Bozkurt

Kılıç

2015

Transplantation Proceedings

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“…Opelz et al (21) observed that the best renal allograft survival was from identical twins; the second was from haploidentical couples, and the poorest survival was from deceased donors (22) . However, multiple risk factors such as donor age, delayed graft function, number of HLA mismatches, infections, and de novo anti-HLA antibodies also affect graft survival, in addition to pre-transplantation antibody characteristics (23) .…”

Section: Discussionmentioning

confidence: 99%

The Assessment of HLA Sensitization Effect on Graft Function and Survival in Renal Transplant Recipients

Güleç¹,

Ayna²,

Soyöz³

et al. 2021

Terh

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Objective: Anti-human leukocyte antibodies (HLA) play an important role in graft survival, particularly in kidney transplantation. Preformed anti-HLA antibodies, especially donor specific antibodies can cause acute and chronic rejections. In this study, it was aimed to assess the effects of anti-HLA antibodies in kidney patients before transplant on graft function, failure, and patient survival. Methods: PRA (Panel Reactive Antibody) levels were monitored using bead based methods such as Luminex and flow cytometry. Post-transplant estimated glomerular filtration ratios (eGFR) among first, third, and fifth year patient survivals and graft failures were statistically analyzed. Results: In this study, it was observed that related transplants had low levels of PRAs, and their eGFRs were at normal reference range. The patients without acute rejection episode (ARE) had higher eGFR values than those with ARE. When five year-graft survival terms were evaluated, it was found that 65.6±9.8% and 86.5±3.2% graft survival terms were detected in anti-HLA Class I/II positive and negative patients, whereas 74.8±6.4% and 84.3 ±2.6% graft survival terms were observed in ARE positive and negative patients, respectively. eGFR value is a predictor of graft failure and patient survival. Our Cox regression analyses (HR=0.843, p=0.00) also supported this information. Conclusion: The study concluded that although the correlation between PRA positivity and graft survival were not significant, the shortest graft survival was observed in PRA positive patients in the whole cohort and ARE positive patients. The importance and requirement of pre- and post-transplant PRA tests continue.

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“…This study also showed that transplant rejection significantly affected graft function (51.27 ± 12.05 vs. 71.74 ± 18.42). Several studies have reported that a lower GFR at the 1 year follow-up is a negative factor for long-term graft survival (19)(20)(21). It is important to account for the rejection rate because steroid megadoses and increased immunosuppression are used to treat rejection and could influence subsequent cardiovascular events.…”

Section: Discussionmentioning

confidence: 99%

One year follow-up of the cardio-metabolic profile evolution in renal transplant patients treated with alemtuzumab, cyclosporine, and steroids in a reference hospital in Colombia

Nieto-Ríos

Gómez-Rueda

Serna-Higuita

et al. 2015

iatreia

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Introduction: Cardiovascular events occur 50 times more often in kidney transplant patients than in the general population and are the leading cause of death. The aim of the study was to evaluate the behavior of cardio-metabolic profile and determine the incidence of major cardiovascular events in the first year after transplantation. Methods: This prospective study evaluated the behavior of cardio-metabolic profile in adult patients that were transplanted during 2011. Results: The median age was 44.3 ± 12.05 years, 68.7 % were men and 95.5 %, hypertensive. Alemtuzumab-cyclosporine and steroids were used in 89.6 %, delaying the introduction of the antimetabolite. In the first year after transplantation there were three cases of diabetes mellitus, three major cardiovascular events, and 12 cases of acute rejection. Albumin, hemoglobin, weight, body mass index (BMI), calcium and HbA1C increased (p<0.05), whereas paratohormone, phosphorus, creatinine and uric acid decreased (p<0.05). Glomerular filtration rate (GFR) was higher in patients without rejection (p=0.001). Conclusion: This immunosuppressive protocol with alemtuzumab, cyclosporine and steroids, and the delayed introduction of the antimetabolite improved bone mineral metabolism, uric acid, albumin and hemoglobin, but there were negative effects on HbA1c, weight and BMI. There was a low incidence of new onset diabetes mellitus and major cardiovascular events.

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Factors That May Influence Estimated Glomerular Filtration Rate in Patients With Excellent Graft Function 10 Years Posttransplant

Cited by 4 publications

References 12 publications

Marginal Donors in Renal Transplantation

Marginal Donors in Renal Transplantation

The Assessment of HLA Sensitization Effect on Graft Function and Survival in Renal Transplant Recipients

One year follow-up of the cardio-metabolic profile evolution in renal transplant patients treated with alemtuzumab, cyclosporine, and steroids in a reference hospital in Colombia

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