Factors That Affect Serum Levels of Ferritin in Australian Adults and Implications for Follow-up

McKinnon, E.; Rossi, Enrico; Beilby, John; Trinder, Debbie; Olynyk, John K.

doi:10.1016/j.cgh.2013.07.019

Cited by 44 publications

(44 citation statements)

References 27 publications

(27 reference statements)

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“…Increased SF is found in 30% of individuals with NAFLD [44] and an Australian population study found a positive correlation between SF and body mass index (BMI) [2]. A BMI of ≥25 kg/m 2 was associated with higher levels of SF in men aged more than 35 years of age and postmenopausal women, when compared to those with a BMI b 25 kg/m 2 of similar age.…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 98%

“…A cross sectional study showed alcohol consumption of one standard drink per day (10 g alcohol) is associated with 21% higher SF in women aged ≤ 49 years compared to women who abstain from alcohol consumption [2][3][4]. Thus, it is critical to ascertain the amount, frequency and pattern of alcohol intake in hyperferritinaemia.…”

Section: Alcoholmentioning

confidence: 98%

“…An Australian population study compared the levels of SF between age-matched cohorts in 1995 and 2005 and demonstrated SF increased by 21% in men and 10% in women over time with a significant increase in the number of individuals with elevated SF above the conventional 300 μg/L [2]. This trend was similarly detected in an American and Canadian population study where 26% of men and 13% of women without HFE mutations had an SF above the conventional cut off of 300 μg/L and 200 μg/L respectively [6].…”

Section: Serum Ferritin and Hyperferritinaemiamentioning

confidence: 98%

“…A BMI of ≥25 kg/m 2 was associated with higher levels of SF in men aged more than 35 years of age and postmenopausal women, when compared to those with a BMI b 25 kg/m 2 of similar age. The range of SF was 413 to 696 μg/L in men greater than 35 years of age with BMI ≥ 25 kg/m 2 and 249 μg/L to 422 μg/L in postmenopausal women with BMI of ≥25 kg/m 2 [2]. Comparatively, the range of SF was 350 to 511 μg/L in men more than 35 years of age with BMI b 25 kg/m 2 and 222 μg/L to 323 μg/L in post-menopausal women with BMI of b 25 kg/m 2 [2].…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

“…Conventionally, the reference range for SF is considered to be 30-300 μg/L for men and postmenopausal women and 15-200 μg/L for premenopausal women, although different laboratories have different reference ranges [2]. Age, gender, menopausal status, weight and lifestyle factors, such as alcohol intake and smoking can influence SF [2][3][4][5].…”

Section: Serum Ferritin and Hyperferritinaemiamentioning

confidence: 99%

See 4 more Smart Citations

How should hyperferritinaemia be investigated and managed?

Ong

Nicoll

Delatycki

2016

European Journal of Internal Medicine

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Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 98%

Section: Alcoholmentioning

confidence: 98%

Section: Serum Ferritin and Hyperferritinaemiamentioning

confidence: 98%

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Section: Serum Ferritin and Hyperferritinaemiamentioning

confidence: 99%

See 3 more Smart Citations

How should hyperferritinaemia be investigated and managed?

Ong

Nicoll

Delatycki

2016

European Journal of Internal Medicine

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Elevated Serum Ferritin

VanWagner

Green

2014

JAMA

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Genotype–Phenotype Relationship in Hereditary Hemochromatosis

Ayres

Jayasekeran

Olynyk

2013

Encyclopedia of Life Sciences

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The majority of patients of northern European descent with hereditary hemochromatosis are homozygous for the C282Y mutation in the HFE gene product. A significant proportion of patients with this genotype have elevated iron indices; however, most will not develop symptoms or organ damage. Age, gender and alcohol are the key factors known to influence this wide variation in clinical penetrance. The authors describe the three stages of disease ranging from only genetic abnormality to overt disease and review the other factors that modify the genotype–phenotype relationship. Algorithms for use in clinical practice are included to aid clinicians in diagnosis, risk stratification and treatment. Key Concepts: Mutations in the HFE gene are relatively common. The vast majority of patients with iron overload are homozygous for the C282Y mutation in the HFE gene product. Biochemical penetrance, that is, elevated iron stores are present in 70–91% of males and 30–60% of females who are C282Y homozygotes. End‐organ damage is less common and occurs in approximately one‐quarter of males and 1% of females. End‐organ damage is extremely unlikely if serum ferritin is less than 1000 µg l −1 . The principal modifiers of disease are gender, age and alcohol. The wide variation in expression of clinical disease is largely unexplained. Various genes have been shown to have variable modifying effects on disease penetrance. Phlebotomy is a safe and effective treatment that depletes iron stores, prevents end‐organ damage and confers normal life expectancy. It is best initiated on discovery of elevated iron stores, that is, stage‐II or stage‐III disease.

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Factors That Affect Serum Levels of Ferritin in Australian Adults and Implications for Follow-up

Cited by 44 publications

References 27 publications

How should hyperferritinaemia be investigated and managed?

How should hyperferritinaemia be investigated and managed?

Elevated Serum Ferritin

Genotype–Phenotype Relationship in Hereditary Hemochromatosis

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