Elevated Serum Ferritin

VanWagner, Lisa B.; Green, Richard M.

doi:10.1001/jama.2014.302

Cited by 5 publications

(3 citation statements)

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“…This remains a poor explanation because 68.5% of those tested did not carry a C282Y allele, which is unlikely if they are a first-degree relative of homozygous C282Y hemochromatosis patients. The cost for ferritin and transferrin measurements is approximately $25 each (16). Additionally, first-degree relatives may still be at elevated risk if a non-HFE C282Y mechanism is the reason for iron accumulation.…”

Section: Who Should Undergo Genetic Testing For Hemochromatosis?mentioning

confidence: 99%

Examining the Clinical Use of Hemochromatosis Genetic Testing

Lanktree

Paré

et al. 2015

Canadian Journal of Gastroenterology and Hepatology

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Section: Who Should Undergo Genetic Testing For Hemochromatosis?mentioning

confidence: 99%

Examining the Clinical Use of Hemochromatosis Genetic Testing

Lanktree

Paré

et al. 2015

Canadian Journal of Gastroenterology and Hepatology

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“…Ferritin is an acute phase reactant. Inflammatory states, including other liver diseases, alcohol use, and obesity, can lead to false-positive ferritin elevations …”

Section: Clinical and Laboratory Characteristicsmentioning

confidence: 99%

Diagnosis and Management of Hereditary Hemochromatosis

Cabrera

Crespo

VanWagner

2022

JAMA

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“…2 Ferritin is storage form of iron and reflects the iron status of the body. [2][3][4] Evidence suggests that reduced iron stores are associated with false high levels of HbA1c in non-diabetic individuals. [5][6][7] Glycosylated haemoglobin (HbA1c) is a gold standard to assess the blood sugar changes in the past 3 months.…”

mentioning

confidence: 99%

Correlation of iron deficiency anaemia with glycosylated haemoglobin (HbA1c) levels in non-diabetics: an observational study

Dhapale

Kamble

2021

Int J Adv Med

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Background: Alteration of HbA1c in other conditions such as haemolytic anaemia, pregnancy and haemoglobinopathy has raised questions about its correlation with iron stores. The aim of the study was to correlate iron deficiency anaemia with glycosylated haemoglobin levels among non-diabetics.Methods: The present study was an observational study among non-diabetic patients of iron deficiency anaemia attending our outpatient department. The study was conducted in the department of medicine of a tertiary care hospital in Maharashtra. All the non-diabetic patients more than 18 years with iron deficiency anaemia were included in the present study. Patients with acute coronary syndromes, chronic liver, chronic kidney diseases, malignancies, haemolytic anaemia, pregnancy, HIV positive with known end stage cardiopulmonary disease were excluded from the study.Results: About 86.33% of the patients had mild to moderate anaemia and 10.7% had severe anaemia in the present study. The average values of haemoglobin, serum ferritin, total iron binding capacity, mean corpuscular volume, mean corpuscular haemoglobin, and mean corpuscular haemoglobin concentration and hematocrit significantly improved after the treatment. With treatment of anaemia, glycosylated haemoglobin, fasting blood sugars and post prandial blood sugars also improved significantly when compared to baseline (p<0.001).Conclusions: The average values of haemoglobin, serum ferritin, total iron binding capacity, mean corpuscular volume, mean corpuscular haemoglobin, and mean corpuscular haemoglobin concentration and hematocrit significantly improved after the treatment. With treatment of anaemia, glycosylated haemoglobin, fasting blood sugars and post prandial blood sugars also improved significantly when compared to baseline.

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Elevated Serum Ferritin

Cited by 5 publications

References 10 publications

Examining the Clinical Use of Hemochromatosis Genetic Testing

Examining the Clinical Use of Hemochromatosis Genetic Testing

Diagnosis and Management of Hereditary Hemochromatosis

Correlation of iron deficiency anaemia with glycosylated haemoglobin (HbA1c) levels in non-diabetics: an observational study

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