Factors relating to a successful cryopreserved blastocyst transfer program

Behr, Barry; Gebhardt, J.; Lyon, J.; Milki, Amin A.

doi:10.1016/s0015-0282(01)03267-8

Cited by 97 publications

(20 citation statements)

References 19 publications

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“…We defined good quality blastocysts based on a study by della Ragione et al showing that 4AA, 4AB, or better blastocysts have better implantation potential and pregnancy outcome compared to poorer quality blastocysts after a single embryo transfer [20]. Any expanding, expanded, and hatching blastocysts with good inner cell mass and trophectoderm epithelium (3BB or better) were frozen on day 5 or day 6 with protocols described elsewhere [21]. Embryos which either arrested or were of worse quality than 3BB were discarded or donated to research.…”

Section: Methodsmentioning

confidence: 99%

Poor Prognosis with In Vitro Fertilization in Indian Women Compared to Caucasian Women Despite Similar Embryo Quality

et al. 2009

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BackgroundDisease prevalence and response to medical therapy may differ among patients of diverse ethnicities. Poor outcomes with in vitro fertilization (IVF) treatment have been previously shown in Indian women compared to Caucasian women, and some evidence suggests that poor embryo quality may be a cause for the discrepancy. In our center, only patients with the highest quality cleavage stage embryos are considered eligible for extending embryo culture to the blastocyst stage. We compared live birth rates (LBR) between Indian and Caucasian women after blastocyst transfer to investigate whether differences in IVF outcomes between these ethnicities would persist in patients who transferred similar quality embryos.Methodology/Principal FindingsIn this retrospective cohort analysis, we compared IVF outcome between 145 Caucasians and 80 Indians who had a blastocyst transfer between January 1, 2005 and June 31, 2007 in our university center. Indians were younger than Caucasians by 2.7 years (34.03 vs. 36.71, P = 0.03), were more likely to have an agonist down regulation protocol (68% vs. 43%, P<0.01), and were more likely to have polycystic ovarian syndrome (PCOS), although not significant, (24% vs. 14%, P = 0.06). Sixty eight percent of Indian patients had the highest quality embryos (4AB blastocyst or better) transferred compared to 71% of the Caucasians (P = 0.2). LBR was significantly lower in the Indians compared to the Caucasians (24% vs. 41%, P<0.01) with an odds ratio of 0.63, (95%CI 0.46–0.86). Controlling for age, stimulation protocol and PCOS showed persistently lower LBR with an adjusted odds ratio of 0.56, (95%CI 0.40–0.79) in the multivariate analysis.Conclusions/SignificanceDespite younger age and similar embryo quality, Indians had a significantly lower LBR than Caucasians. In this preliminary study, poor prognosis after IVF for Indian ethnicity persisted despite limiting analysis to patients with high quality embryos transferred. Further investigation into explanations for ethnic differences in reproduction is needed.

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Section: Methodsmentioning

confidence: 99%

Poor Prognosis with In Vitro Fertilization in Indian Women Compared to Caucasian Women Despite Similar Embryo Quality

et al. 2009

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“…In this grading system, blastocysts are assessed in three ways: a numerical score from one to six describing the degree of expansion and hatching; followed by a letter A, B, or C grading the inner cell mass; followed by a letter A, B, or C grading the trophectoderm. Any expanding, expanded, and hatching blastocysts with good inner cell mass and trophectoderm epithelium (3BB or better) were frozen on day 5 or day 6 with protocols described elsewhere [10]. Embryos which either arrested or were of worse quality than 3BB were discarded or donated to research.…”

Section: Embryo Quality Assessmentmentioning

confidence: 99%

Embryo quality before and after surgical treatment of endometriosis in infertile patients

Shahine

Burney

Behr

et al. 2009

J Assist Reprod Genet

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“…The decision of which blastocyst to transfer was based on the definition of the inner cell mass and trophectoderm and the degree of expansion, with the remaining blastocysts cryopreserved on day 5 or 6 as previously described [28]. …”

Section: Materials/methodsmentioning

confidence: 99%

Age-Related Success with Elective Single versus Double Blastocyst Transfer

Friedman

Davis

Lathi

et al. 2011

ISRN Obstetrics and Gynecology

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Background. Although the optimal outcome of assisted reproductive technology (ART) is a healthy singleton pregnancy, the rate of twin gestation from ART in women over the age of 35 is persistently high. Methods/Findings. We compared clinical pregnancy rates (PRs), ongoing pregnancy/live birth rates, and multiple gestation rates (MGRs) in 108 women who chose elective single blastocyst transfer (eSBT) to 415 women who chose elective double blastocyst transfer (eDBT) at a hospital-based IVF center. There was no significant difference in PR between eSBT and eDBT (57.4% versus 50.2%, P = 0.47) nor between eSBT and eDBT within each age group: <35, 35–37, 38–40, and >40. The risk of multiple gestations, however, was greatly increased between eSBT and eDBT (1.6 versus 32.4%, P < 0.00005), and this difference did not vary across age groups. Conclusion(s). Women undergoing eDBT are at uniformly high risk of multiple gestation regardless of age. eSBT appears to significantly lower the risk of multiple gestation without compromising PR.

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Factors relating to a successful cryopreserved blastocyst transfer program

Cited by 97 publications

References 19 publications

Poor Prognosis with In Vitro Fertilization in Indian Women Compared to Caucasian Women Despite Similar Embryo Quality

Poor Prognosis with In Vitro Fertilization in Indian Women Compared to Caucasian Women Despite Similar Embryo Quality

Embryo quality before and after surgical treatment of endometriosis in infertile patients

Age-Related Success with Elective Single versus Double Blastocyst Transfer

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