Embryo quality before and after surgical treatment of endometriosis in infertile patients

Shahine, Lora K.; Burney, Richard O.; Behr, Barry; Milki, Amin A.; Westphal, Lynn M.; Lathi, Ruth B.

doi:10.1007/s10815-008-9287-1

Cited by 17 publications

(11 citation statements)

References 19 publications

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“…The three groups did not present with any other statistically significant differences. This is in partial agreement with previous literature 17 . A possible reason behind this, is that Shahine and colleagues evaluated strictly the percentage of good quality blastocysts, whereas in the present study the difference originates from the poor-quality blastocysts.…”

Section: Discussionsupporting

confidence: 94%

Couples with mild male factor infertility and at least 3 failed previous IVF attempts may benefit from laparoscopic investigation regarding assisted reproduction outcome

Pantou¹,

Sfakianoudis²,

Maziotis

et al. 2020

Sci Rep

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the aim of this study is to assess the value of laparoscopy for couples diagnosed with mild male factor infertility and at least three previous failed In-Vitro Fertilization (IVF) attempts. A total of 169 couples were included in this prospective cohort study. patients were presented with the option of being subjected to laparoscopic investigation for correction of previously unidentified endometriosis or pelvic adhesions. The outcome measures were Live Birth/Ongoing Pregnancy, clinical pregnancy and positive hCG rate. One-hundred and one of them opted for, whereas 68 opted against laparoscopic investigation. All patients proceeded with a single ICSI cycle. Following laparoscopic investigation, 43 patients were diagnosed with endometriosis, 22 with adhesions, while for 36 patients laparoscopic investigation provided no further diagnosis. No statistically significant differences were observed regarding baseline hormonal levels and other characteristics between the two groups and the three subgroups. When compared to the no-laparoscopy group, women subjected to laparoscopy presented with a higher clinical pregnancy and ongoing pregnancy/live birth rate. following endometriosis correction, a marginally non-statistically significant trend was observed regarding a decrease in poorquality blastocysts (p = 0.056). A statistically significant higher clinical pregnancy (p = 0.03) and ongoing pregnancy/live birth rate was observed in the endometriosis group when compared to male factor infertility only (p = 0.04). Laparoscopic identification and correction of undiagnosed endometriosis in couples initially diagnosed with male infertility and at least 3 failed previous IVF attempts, appears to be a promising approach efficiently addressing infertility for these patients while avoiding IVF overuse.Male factor infertility stands as a common infertility etiology, identified in up to 50% of infertile couples 1 , as the sole etiology or coupled with female factor infertility. Studies on male factor infertility, provide robust data that this may be successfully managed through in vitro fertilization (IVF) treatment, ensuring high implantation and pregnancy rates 2 . In fact, even severe and challenging cases of male factor infertility could be effectively managed, through the employment of a wide pallet of techniques improving standard employment of Intracytoplasmic Sperm Injection (ICSI) along with fertilization rates 3 . Male infertility has been categorized as mild, moderate or severe 4 . Mild male factor infertility does not present with a strict definition, including a range of different

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Section: Discussionsupporting

confidence: 94%

Couples with mild male factor infertility and at least 3 failed previous IVF attempts may benefit from laparoscopic investigation regarding assisted reproduction outcome

Pantou¹,

Sfakianoudis²,

Maziotis

et al. 2020

Sci Rep

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“…The relative importance of these two traumas remains to be clarified 16 . Ovarian endometriosis affects oocyte number but not embryo quality or pregnancy outcome, irrespective of the presence of ovarian endometrioma, 17 and irrespective of the stage of endometriosis 18 . Surgical management of endometriomas has no significant effect on IVF pregnancy rates and ovarian response to stimulation compared with no treatment, as shown by a recent meta‐analysis based on five studies 19 .…”

Section: Endometriomamentioning

confidence: 99%

Endometriosis and assisted reproduction techniques

Härkki

Tiitinen

Ylikorkala

2010

Annals of the New York Academy of Sciences

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Endometriosis-associated infertility is poorly treatable with various forms of surgery. Therefore, assisted reproduction techniques (ARTs), such as controlled ovarian hyperstimulation, intrauterine insemination, or in vitro fertilization, are commonly used for endometriosis-associated infertility. Endometriosis impairs the efficacy of in vitro fertilization. There is no evidence that ovulation suppression before ART would enhance the efficacy of ART. Resection of minimal/mild endometriosis and/or restoration of the normality of pelvic anatomy may enhance the efficacy of ART, but aggressive ovarian surgery should be avoided, because it reduces the ovarian reserves and the likelihood of pregnancy after ART. The outcome of ART pregnancy is not affected by the history of endometriosis, but the presence of endometrioma may predispose to preterm birth or fetal growth retardation in ART-induced pregnancies. As a whole, infertility due to endometriosis is best treated with various forms of ART, and the earlier clinicians apply these techniques, the more likely pregnancy may ensue.

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“…In addition, the effect of laparoscopic resection in our study group on IVF-ET outcomes was uncertain. Shahine et al hypothesized that surgical treatment of endometriosis might result in improved embryo quality (19). This study included 17 patients with stage I/II endometriosis who underwent IVF-ET before and after surgical treatment for endometriosis (19).…”

Section: Discussionmentioning

confidence: 99%

Effects of early endometriosis on IVF-ET outcomes

Mekaru

Yagi²,

Asato³

et al. 2013

Front Biosci

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There have been very few reports on the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in women with stage I/II endometriosis. The objective of this study was to investigate IVF-ET outcomes in women with early-stage endometriosis. We enrolled 35 women less than 40 years with unexplained infertility who underwent IVF-ET into the study. We compared 18 women with stage I/II endometriosis according to the revised American Society for Reproductive Medicine classification for endometriosis, who underwent 39 IVF-ET cycles (En (+) group) with 17 women without endometriosis who underwent 41 IVF-ET cycles (En (-) group). Higher requirements of total gonadotropin, a lower percentage of high-quality embryos of all fertilized eggs (9.0% vs. 16.3%), a relatively lower pregnancy rate (33.3% vs. 41.5%), and a lower live birth rate (25.6% vs. 34.1%) were observed in the En (+) group. Although no significant effect on IVF-ET outcome was observed, ovarian response may be decreased in women with stage I/II endometriosis. Considering the decreased number of high-quality embryos in the En (+) group, stage I/II endometriosis may have detrimental effects on embryo quality.

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Embryo quality before and after surgical treatment of endometriosis in infertile patients

Abstract: Purpose To investigate the hypothesis that surgical treatment of endometriosis in infertile patients may improve pregnancy rates by improving embryo quality.

Cited by 17 publications

References 19 publications

Couples with mild male factor infertility and at least 3 failed previous IVF attempts may benefit from laparoscopic investigation regarding assisted reproduction outcome

Couples with mild male factor infertility and at least 3 failed previous IVF attempts may benefit from laparoscopic investigation regarding assisted reproduction outcome

Endometriosis and assisted reproduction techniques

Effects of early endometriosis on IVF-ET outcomes

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