Factors Related To Venous Ulceration

Vlajinac, Hristina; Marinković, Jelena; Maksimović, M.; Radak, Djordje

doi:10.1177/0003319713508218

Cited by 39 publications

(50 citation statements)

References 37 publications

(50 reference statements)

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“…Eventually, five studies, two case–control and three cross‐sectional studies, were included in the qualitative synthesis. Heterogeneity of the studies prevented us from doing a meta‐analysis.…”

Section: Resultsmentioning

confidence: 94%

“…In all studies, age and gender were investigated, matched for, or controlled for in VLU patients compared to CVD <C5 patients. In three studies, age was significantly higher in the VLU group compared to age in the CVD <C5 group . One study found no significant difference in age between the VLU group and CVD <C5 group.…”

Section: Resultsmentioning

confidence: 96%

“…Moreover, in each of the included studies, the comparability of cases and controls differed. Some studies adjusted for age and gender in a multivariate analysis, while another study conducted a univariate analysis only, or did not show the multivariate analysis . In addition, one study did not report a non‐response rate, two studies used medical records only so non‐response was not possible; in one study there was a rate difference of 17% in the non‐respondents and in one study a large amount of cases and controls could not be contacted because of missing phone numbers.…”

Section: Resultsmentioning

confidence: 99%

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A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

Meulendijks

Vries

Dooren

et al. 2019

Acad Dermatol Venereol

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Venous Leg Ulcers (VLU) occur in about 1% of the Western population. A VLU takes 3–12 months to heal, it recurs often, and it has a negative impact on the quality of life. The risk factors for the development of a first VLU are not well‐understood and prevention of a first VLU therefore remains underappreciated. The aim of this study was to identify risk factors for developing a first VLU in adults (aged > 18 years) by searching the literature. We searched the Cochrane Library, Pubmed, Cinalh and Narcisto identify studies that investigated risk factors in developing a VLU. The last search was performed in January 2018. Two reviewers independently reviewed the abstracts and full‐text articles, and assessed the methodological quality of the included studies. Results of studies using duplex scanning, and comparing participants with and without VLUs were included in the qualitative analysis. Where possible a quantitative meta‐analysis was conducted. We found five studies that investigated the relation of several risk factors with VLU development. The methodological differences of the studies made it impossible to perform a quantitative analysis. The risk factors higher age (four studies), higher body mass index (four studies), low physical activity (four studies), arterial hypertension (four studies), deep vein reflux (three studies), deep venous thrombosis (three studies) and family history of VLU (three studies) were significantly associated with a VLU in the majority of the studies. To what extent they influence the development of a VLU remains unclear because of the limited number of studies that investigated the association of these risk factors with VLU development, and the heterogeneity of these studies. Further studies are needed to confirm the association of these risk factors with the development of a VLU and to explore overweight and low physical activity in more detail.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

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A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

Meulendijks

Vries

Dooren

et al. 2019

Acad Dermatol Venereol

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“…Bizim çalışmamızda da literatür ile uyumlu olarak kadın hastalar çoğunluktaydı. Hastalarda VY şiddeti ve süresi arttıkça eşlik eden arteryel hipertansiyon, kalp yetmezliği, DM, PAH, kronik obstrüktif akciğer hastalığı, iskelet sistemi yada eklem hastalıklarının sıklığı da artmaktadır [16][17]. Trombositlerin endotel hasarı ve hemostazda çok önemli rolü mevcuttur, ayrıca aterotromboz gelişiminde de önemlidirler.…”

Section: Bulgularunclassified

Mean Platelet Volume in Patients with Chronic Venous Insufficiency

Sarıca

Kızıldağ²,

Selçuk³

et al. 2016

J Clin Exp Invest

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ÖZET Amaç: Ortalama trombosit hacmi (OTH) trombosit aktivitesinin iyi bir göstergesi olduğu, inflamatuar süreçler ile seyreden hastalıklarda ve ayrıca vasküler hastalıklarda arttığı bildirilmektedir. Bu çalışmada kronik venöz yetmezliği (KVY) olan hastalarda ortalama trombosit hacminin KVY'deki klinik önemi ve KVY'e işaret eden bir belirteç olma olasılığı araştırıldı.Yöntemler: Retrospektif olarak planlanan bu çalışmaya renkli Doppler Ultrasonografi (RDUS) yöntemi ile KVY tanısı almış 117 hasta ile 49 sağlıklı gönüllü kontrol grubu olarak alındı. Hastaların RDUS değerlendirmesi öncesinde veya sonrasında 1 ay içindeki kan sayımı değerleri hastane yönetim sisteminden kaydedildi. KVY' si bulunan hastalar ve kontrol grubu arasında hemogram, rutin biyokimyasal tetkikleri ve tiroid fonksiyon testleri karşılaştırıldı. Bulgular:Hasta ve kontrol grubu arasında kreatinin, aspartat aminotransferaz, alanin aminotransferaz, total kolesterol, LDL kolesterol, HDL kolesterol, trigliserid, eritrosit sedimantasyon hızı, lökosit, hemoglobin, trombosit düzeyleri açısından anlamlı farklılık saptanmadı (p>0.05). Tiroid stimülan hormon ve OTH düzeyleri kontrol grubunda istatistiksel olarak anlamlı düşüktü (p<0.05).Sonuç: Kronik venöz yetmezliği olan hastalarda OTH' nin kontrol grubuna göre daha yüksek olduğu ilk defa gösterildi. Ulaşımı kolay, ucuz, pratik olan ortalama trombosit hacmi, KVY'si olan hastalarda takip belirteci olarak kullanılabilir. ABSTRACTObjective: the mean platelet volume (MPV) is a good indicator of platelet activity; it is reported to increase in diseases associated with inflammatory processes and in vascular diseases. This study investigated the importance of mean platelet volume in patients with chronic venous insufficiency (CVI) and whether the MPV was likely to be a predictor of the CVI.Methods: 117 patients who were diagnosed as CVI by colored Doppler Ultrasound (CDU) method and 49 healthy volunteers (forming the control group) were enrolled to this study, which was planned retrospectively. The patients' blood count values taken within one month before and after the CDU evaluation were recorded by the hospital information system. The complete blood count, routine biochemical tests and thyroid function tests of the patients diagnosed with CVI were compared to the control group.Results: Significant differences were not detected between the patients and the control group in terms of the levels of creatinine, aspartate aminotransferase, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, erythrocyte, sedimentation speed, leukocyte, haemoglobin and thrombocyte (p>0.05). The thyroid stimulating hormone and the MPV levels were significantly lower in the control group (p<0.05). Conclusion:MPV levels as an easy, cheap and practical data extracted from complete blood count, were found higher in patients diagnosed with CVI compared to the control group. This may be originated from endothelium changes as an answer to venous hypertension and dilatation in CVI. MPV can be used as a follow-up marker in CVI pa...

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“…4 Many studies have suggested a higher prevalence of VLU in women, 5 but this disparity decreased with age, 6,7 and in fact a more recent cross-sectional study suggested male gender carried a higher risk to develop VLU. 8 Nevertheless, the overall economic and social burden worldwide is huge.…”

Section: Introductionmentioning

confidence: 99%

Venous leg ulceration pathophysiology and evidence based treatment

Chi

Raffetto

2015

Vasc Med

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Venous leg ulceration (VLU) is one of the most predominate medical disorders worldwide and in the western hemisphere it affects around 1.5% of the general population and up to 5% of the elderly population. Unfortunately, this trend will only increase given the growth of an aging population worldwide. Understanding its pathophysiology that begins with venous hemodynamic abnormalities and leads to inflammatory alterations with microcirculatory changes is critical to delivering effective curative therapy. As such, the main component to treatment is reversing the underlying venous hypertension and pro-inflammatory milieu using compression treatment along with various adjuvant therapies. Given its impact, a comprehensive multi-pronged approach to care, treatment and prevention is required to reverse the increasing trend that is observed worldwide.

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Factors Related To Venous Ulceration

Cited by 39 publications

References 37 publications

A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

A systematic review on risk factors in developing a first‐time Venous Leg Ulcer

Mean Platelet Volume in Patients with Chronic Venous Insufficiency

Venous leg ulceration pathophysiology and evidence based treatment

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