Factors predictive of drop‐out and weight loss success in weight management of obese patients

Hadžiabdić, Maja Ortner; Mucalo, Iva; Hrabač, Pero; Matić, Tomas; Rahelić, Dario; Božikov, Velimir

doi:10.1111/jhn.12270

Cited by 90 publications

(110 citation statements)

References 41 publications

(49 reference statements)

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“…The short time of follow-up may have restricted the ability to detect meaningful long-term differences. In this sense, a recent study has detected that the initial body weight loss (at 1 month) is a positive predictor of weight loss after 12 months of intervention [53]. Although the findings of this investigation are based on a population of a nutritional service based on the genetic makeup, the participants included in the study were not necessarily representative of the general population.…”

Section: Discussionmentioning

confidence: 98%

Gene-Gene Interplay and Gene-Diet Interactions Involving the MTNR1B rs10830963 Variant with Body Weight Loss

et al. 2014

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Background/Aims: Investigation of the genetic makeup may facilitate the implementation of more personalized nutritional interventions. The aims were to examine whether the rs10830963 MTNR1B polymorphism affects weight loss in response to a hypocaloric diet and to find potential gene-gene interplays and gene-diet interactions. Methods: 167 subjects enrolled in a personalized nutritional intervention for weight loss (3-6 weeks) were examined for anthropometric measurements, dietary habits and physical activity at baseline and at the first follow-up visit. Three polymorphisms, which have previously been associated with body weight regulation, rs10830963 (MTNR1B), rs9939609 (FTO) and rs17782313 (MC4R), were analyzed using the Luminex® 100/200™ System. Results: After adjusting for covariates, females with the rs10830963 CG/GG genotype showed lower weight loss than those with the CC genotype. In the total population, carriers of variant alleles of both FTO and MC4R showed a significant association with MTNR1B and weight loss outcome. Moreover, among women, higher total protein and animal protein intakes were associated with a lower weight loss in G allele carriers of the MTNR1B variant. Conclusions: Our data evidenced that rs10830963 MTNR1B polymorphism could be associated with individual differences in weight loss induced by a hypocaloric diet. This association was influenced by FTO and MC4R loci and modified by baseline protein intake.

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Section: Discussionmentioning

confidence: 98%

Gene-Gene Interplay and Gene-Diet Interactions Involving the MTNR1B rs10830963 Variant with Body Weight Loss

et al. 2014

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“…Several researchers have previously demonstrated that initial weight loss is associated with study dropout in dietary based weight loss trials [9][10][11][12][13][14][15][16] , however this finding is not consistent and others have found no relationship 11,17,18 . This is the first study to quantify the amount of initial weight loss which predicts dropout and to investigate and quantify additional easily obtainable subject characteristics such as age which can be used to ensure adequate randomisation.…”

Section: Discussionmentioning

confidence: 99%

“…Where a relationship does exist it appears that females may be more likely to drop out than males 2 , although a more recent study has shown that males are more likely to drop out than females 23 . The 2011 systematic review found roughly equal (but small n=4-5) numbers of papers supporting a relationship between high or low initial weight and attrition compared with 18 reporting no relationship more recent papers continue to differ with some supporting the relationship between higher initial weight 18,20 and attrition and some lower initial weight 15 (although no relationship is still the most frequent 9,17,19 ).…”

Section: Discussionmentioning

confidence: 99%

Predicting dropout in dietary weight loss trials using demographic and early weight change characteristics: Implications for trial design

Batterham

Tapsell

Charlton

2016

Obesity Research & Clinical Practice

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“…Low sodium, low protein, and weight loss diets are notoriously difficult to maintain over the long term and the increased water drinking prescription to reduce urinary stone formation and shedding is commonly ignored [43–46]. To counter these tendencies, in the current study we offered a palatable diet, relatively simple to prepare, coupled with intense counseling at the outset.…”

Section: Discussionmentioning

confidence: 99%

Diet and polycystic kidney disease: A pilot intervention study

et al. 2017

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SUMMARY Background & aims Dietary sodium, protein, acid precursors, and water have been linked to cyst growth in polycystic kidney disease; yet, no studies in patients have examined the feasibility of using a dietary intervention that controls all of these factors. The aim of this study was to determine if a diet, appropriate for persons of most ages, reduces the excretion of sodium, urea, acid, and decreases mean urine osmolality while gaining acceptance by patients with autosomal dominant polycystic kidney disease (ADPKD). Methods Twelve adults with ADPKD enrolled in a pre-post pilot feasibility study and served as their own controls. Individuals consumed their usual diet for one week then for four weeks followed an isocaloric diet lower in sodium and protein and higher in fruits, vegetables, and water. Three-day diet records and two 24-h urine samples were collected at baseline, week 2, and week 4 visits; blood pressure, weight, and serum were obtained at all three visits. A modified nutrition hassles questionnaire was completed on the last visit. Results During the dietary intervention, subjects (n = 11) consumed less sodium, protein, and dietary acid precursors 36%, 28%, and 99%, respectively, and increased fluid intake by 42%. Urinary sodium, urea, net acid excretion, osmoles, and osmolality decreased 20%, 28%, 20%, 37%, and 15%, respectively; volume increased 35%. Urine changes were in accord with the diet record. Ninety-one percent of participants reported that none of the hassles were worse than “somewhat severe”, and most participants felt “somewhat confident” or “very confident” that they could manage the new diet. Conclusions A majority of adult patients with ADPKD successfully prepared and followed a composite diet prescription with decreased sodium, protein, acid precursors, and increased fluid intake. This trail was registered at ClinicalTrials.gov (NCT01810614).

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Factors predictive of drop‐out and weight loss success in weight management of obese patients

Cited by 90 publications

References 41 publications

Gene-Gene Interplay and Gene-Diet Interactions Involving the <b><i>MTNR1B </i></b>rs10830963 Variant with Body Weight Loss

Gene-Gene Interplay and Gene-Diet Interactions Involving the <b><i>MTNR1B </i></b>rs10830963 Variant with Body Weight Loss

Predicting dropout in dietary weight loss trials using demographic and early weight change characteristics: Implications for trial design

Diet and polycystic kidney disease: A pilot intervention study

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