Factors predicting survival after diagnosis of laryngeal cancer

Ramroth, Heribert; Schoeps, Anja; Rudolph, Elisabeth; Dyckhoff, Gerhard; Plinkert, Peter K.; Lippert, Burkhard M.; Feist, K; Delank, Klaus-Wolfgang; Scheuermann, Klaus; Baier, G.; Ott, Ingo; Chenouda, Sami; Becher, Heiko; Dietz, Andreas

doi:10.1016/j.oraloncology.2011.08.003

Cited by 50 publications

(53 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a multivariable analysis, Ramroth et al [19] showed that age was the most influential factor affecting prognosis of patients with newly diagnosed laryngeal cancer (hazard ratio = 1.5). Du and colleagues [7] found that age was a prognostic factor in the univariable analysis, but it was not an independent prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Prognostic Factors in 205 Patients with Laryngeal Squamous Cell Carcinoma Who Underwent Surgical Treatment

Zhang

Luo

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

ObjectivesTo investigate the most important factors affecting the prognosis of the patients with squamous cell carcinoma (SCC) of the larynx.MethodsBased on the clinical and follow-up data, 205 patients with SCC of the larynx receiving total laryngectomy, partial laryngectomy, or CO2 laser surgery in GuangDong General Hospital were retrospectively analyzed. A survival analysis was performed by the Kaplan-Meier method and a multivariable analysis of prognostic factors was carried out using the Cox proportional hazard model.ResultsSubtypes of carcinoma included 69.8% glottic and 30.2% supraglottic. Most patients were in N0 stage (77.6%), and 22.4% patients were in N1∼N3 stage. Over half of the patients were in T1∼T2 stage (55.1%), 20.0% in T3, and 24.9% in T4. Mean follow-up duration was 49.2 months. The survival rates 1, 2, and 3 years after the surgery were 99.0%, 91.7%, and 81.5%, respectively. The survival rate for those patients with clinical stage IV was significantly lower than for those with clinical stage I and II (p<0.001 and p = 0.013, respectively). The disease-free progression rates 1, 2, and 3 years after the surgery were 83.9%, 74.6%, and 71.2%, respectively. Futhermore, those patients with a Charlson score of 1 to 2 and ≥3 had higher risk of mortality than those with a Charlson score of 0 (hazard ratios of 1.8 and 2.41 p = 0.042 and p = 0.008). Multivariable analysis revealed that clinical stage, surgical margin, and comorbidity were significantly associated with both mortality and disease-free progression.ConclusionThe surgical resection margin, clinical stage, and comorbidity were independent factors affecting the laryngeal cancer prognosis. The survival rates were lower for patients with advanced laryngeal cancer, positive surgical margins, or severe comorbidity, suggesting the importance of early diagnosis, early treatment, negative surgical margins, and conditions of comorbidity.

show abstract

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Prognostic Factors in 205 Patients with Laryngeal Squamous Cell Carcinoma Who Underwent Surgical Treatment

Zhang

Luo

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In addition, human papillomavirus (HPV) infections have been suggested to play a significant role in the progression of laryngeal cancer [16,40]. There is some evidence that positive family history of laryngeal cancer or other HNSCC (head and neck squamous cell carcinoma) may increase the risk of LCSS development [3,32]. The male/female ratio for the incidence of LCSS is significantly higher than in other tumours in this group [32].…”

Section: Introductionmentioning

confidence: 99%

“…There is some evidence that positive family history of laryngeal cancer or other HNSCC (head and neck squamous cell carcinoma) may increase the risk of LCSS development [3,32]. The male/female ratio for the incidence of LCSS is significantly higher than in other tumours in this group [32]. Stages I and II (early) of laryngeal squamous cell carcinoma are treated by surgery and/or radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

Cybula

Wieteska

Józefowicz-Korczyńska

et al. 2016

CBM

View full text Add to dashboard Cite

Abstract. BACKGROUND:Although the development of novel diagnostic and treatment strategies concerning laryngeal cancer is highly intensive, the survival rate remains virtually unchanged. Small non-coding RNAs appear to be very promising biomarkers -and so remain the focus of extensive investigation in laryngeal cancer. OBJECTIVE: We examined the expression of five miRNA and five genes related to cancer whether they could be potential laryngeal cancer biomarkers. METHODS:We performed an analysis in 47 patients diagnosed with laryngeal cancer. The qPCR technique was used to investigate the expression profile. RESULTS: While miR-21-3p and miR-525-5p were found to be significantly up-regulated, miR-139-3p and miR-885-5p expression is lower in laryngeal cancer. Moreover, PIK3R1 and HACE1 were found to be also down-regulated. CONCLUSIONS: The change in miRNA expression is frequent than the expression of other tested genes. The expression of passenger strands such as miR-21-3p and miR-139-3p, which are rarely investigated, is also significantly affected in laryngeal cancer. While PIK3R1, HACE1, miR-139-3p, and miR-885-5p may act as tumor suppressor genes in the studied tumour type, miR-21-3p and miR-525-5p seem to have oncogenic properties. Our findings suggest that miR-885-5p and PIK3R1 are the best indicators for the classification of laryngeal cancer tissue and normal mucosa.

show abstract

“…A number of factors are believed to contribute to survival after laryngeal cancer diagnosis; the tumor stage, tumor site, treatment strategy, and patient's age and comorbidities are all thought to play a role [4]. Tumor hypoxia is a characteristic of many solid tumors.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients

Surono

Priyanto

Indrasari

2016

Journal of Oncology

View full text Add to dashboard Cite

Objectives. This research aimed to determine the association between hypoxia-inducible factor-1α (HIF-1α) expression and laryngeal squamous cell carcinoma clinical stage. Methods. We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014. HIF-1α expression was analyzed by immunohistochemistry using an anti-HIF-1α mouse monoclonal antibody. The association between HIF-1α expression and clinical stage was analyzed using the chi square test. Results. The glottis was the predominant site of laryngeal squamous cell carcinoma occurrence, and 43/47 (91.5%) patients presented at an advanced stage. Of the advanced stage patients, 27/43 stained positive for HIF-1α expression and 16/43 stained negative. Of the early stage patients, 2/4 stained positive for HIF-1α expression and 2/4 stained negative. Statistical analysis did not demonstrate significant association of HIF-1α expression. Conclusion. There was no statistically significant association between HIF-1α expression and the clinical stage or histological differentiation of LSCC.

show abstract

Factors predicting survival after diagnosis of laryngeal cancer

Cited by 50 publications

References 29 publications

Retrospective Analysis of Prognostic Factors in 205 Patients with Laryngeal Squamous Cell Carcinoma Who Underwent Surgical Treatment

Retrospective Analysis of Prognostic Factors in 205 Patients with Laryngeal Squamous Cell Carcinoma Who Underwent Surgical Treatment

New miRNA expression abnormalities in laryngeal squamous cell carcinoma

Hypoxia-Inducible Factor-1α Expression in Indonesian Laryngeal Squamous Cell Carcinoma Patients

Contact Info

Product

Resources

About