Factors influencing yield of plateletpheresis using intermittent flow cell separator

Abstract

Platelet recovery in the recipient is influenced by the transfused dose of platelets, which in turn is dependent on the quality of single donor platelets (SDPs) in terms of platelet yield. Various donor factors such as predonation platelet count and Hemoglobin (Hb) concentration affect the platelet yield. A total of 61 plateletpheresis procedures performed on intermittent flow cell separator (MCS3p, Hemonetics) were evaluated for platelet yield. A relationship between predonation platelet count and Hb concentration with yield of platelets was studied using Pearson Correlation. The mean platelet yield was 2.9 +/- 0.64 x 10(11). While a direct relationship was observed between predonation platelet count and yield (r = 0.51, P < 0.001), no such correlation was noticed with donor Hb concentration (r = -0.05, P > 0.005). The yield was > or =3 x 10(11) in >80% of procedures when the predonation platelet count was > or =250 x 10(3)/mm. Optimization of platelet yield, which is influenced by predonation platelet count, is an emerging issue in blood transfusion services. However, further studies in this regard are needed using more advanced cell separators.

A 3‐year analysis of plateletpheresis donor deferral pattern in a tertiary health care institute: Assessing the current donor selection criteria in Indian scenario

“…In and around our region, the platelet count observed in healthy donors varies between 150 and 200 3 10 9 /L [3]. A large number of willing donors were deferred falling just short of the acceptance criteria for hemoglobin !12.5 g/dL and platelet count of !150 3 10 9 /L [4] even after repeated testing.…”

Adverse donor reaction during and after plateletpheresis in a tertiary care centre

“…1 The increase in medical and surgical indications for platelet transfusion along with the new technologies available, promoted and increased the use of plateletpheresis. 2 Plateletpheresis should be performed in a specific area and under the guidance and supervision of a physician. 3 Apheresis procedures are usually well tolerated.…”

Assessment of factors affecting the platelet yield using continuous flow cell separator

“…In 12% of the procedures, the mean yield was < 3 x 10 11 /unit when the pre-donation platelet count was < 200 x 10 3 /µl 4 . Many other studies have also demonstrated significant positive correlation between the donor platelet count and the yield of the product [10][11][12] .…”