Factors influencing the stability of ranitidine in TPN mixtures

Allwood, M. C.; Martin, H.

doi:10.1016/s0261-5614(95)80016-6

Cited by 12 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Weinberg and Bell produced the first tissue‐engineered blood vessel using endothelial cells (ECs) and smooth muscle cells (SMCs) in gelatin (12). Since then, various approaches to culturing vascular grafts composed of ECs and SMCs have been developed (13–17). In the process, autologous vessels must be harvested to isolate ECs and SMCs.…”

mentioning

confidence: 99%

A Novel Strategy to Engineer Small‐Diameter Vascular Grafts From Marrow‐Derived Mesenchymal Stem Cells

et al. 2011

View full text Add to dashboard Cite

Tissue-engineered blood vessels have mainly relied on endothelial cells (ECs), smooth muscle cells (SMCs), and biocompatible materials. However, long-term results have revealed several material-related failures, such as stenosis, thromboembolization, and the risk of infection. Furthermore, SMCs from elderly persons have reduced capacity in proliferation and collagen production. Mesenchymal stem cells (MSCs) have the ability to differentiate into multiple cell lineages, including osteoblasts, chondrocytes, ECs, and SMCs. In the current experiment, rabbit MSCs were cultured to form a cell sheet. A tissueengineered vascular graft (TEVG) was fabricated by rolling the MSC sheet around a mandrel.The TEVG was implanted into a defect of the common carotid artery after it was examined macroscopically and microscopically. Hematoxylin and eosin staining showed that cell sheet was composed of five to seven layers of cells with the thickness of 40-50 mm. Results from the adhesion assay revealed that MSCs had similar antiplatelet adhesion property to ECs. Histological analysis of TEVGs showed that the layers of the cell sheet had fully fused in vitro. After implantation, TEVGs had excellent patency and integrated well with the native vessel. The structure of the TEVGs was similar to that of the native artery 4 weeks after implantation. Electron microscopy showed that the implanted TEVGs endothelialized. These results indicated that a completely biological TEVG could be assembled with autologous MSCs. These TEVGs are useful for revascularization in humans, which would reduce the occurrence of complications caused by foreign materials.

show abstract

mentioning

confidence: 99%

A Novel Strategy to Engineer Small‐Diameter Vascular Grafts From Marrow‐Derived Mesenchymal Stem Cells

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Alternatively, if a patient is receiving parenteral nutrition, cimetidine, ranitidine, and famotidine are stable in total nutrient admixtures for 24 hours at room temperature. [169][170][171][172][173][174][175][176][177]…”

Section: Pharmacodynamicsmentioning

confidence: 99%

Upper Gastrointestinal Tract Bleeding in Critically Ill Pediatric Patients

Crill

Hak

1999

Pharmacotherapy

View full text Add to dashboard Cite

Similar to adults, children under physiologic stress can develop an imbalance in defensive (mucosal layer, motility) and aggressive (gastric acid, bile salts, enzymes) factors responsible for maintaining a healthy gastrointestinal tract. Hypoxia in the gastrointestinal tract likely disrupts the defensive factors, thereby permitting damage by aggressive factors to upper gastrointestinal epithelium that may progress to stress ulceration and acute upper gastrointestinal tract bleeding (UGIB). The basic pathophysiology may be similar in children and adults; however, differences in the time to developing ulceration, ulcer location, and number of ulcers have been reported. Functional development of the gastrointestinal tract is influenced by disease, gestational and postnatal age, and exposure to and type of enteral feedings, thereby confounding the development and prophylaxis of UGIB in neonates and infants. In addition, pharmacotherapy decisions are often complicated by drug administration issues and adverse effects.

show abstract

Formulation of Parenteral Nutrition Regimens

Hardy,

Allwood

2023

Intestinal Failure

View full text Add to dashboard Cite

Factors influencing the stability of ranitidine in TPN mixtures

Cited by 12 publications

References 9 publications

A Novel Strategy to Engineer Small‐Diameter Vascular Grafts From Marrow‐Derived Mesenchymal Stem Cells

A Novel Strategy to Engineer Small‐Diameter Vascular Grafts From Marrow‐Derived Mesenchymal Stem Cells

Upper Gastrointestinal Tract Bleeding in Critically Ill Pediatric Patients

Formulation of Parenteral Nutrition Regimens

Contact Info

Product

Resources

About