Factors influencing the long-term results of autologous microvascular submandibular gland transplantation for severe dry eye disease

Zhang, L.; Su, Jia-Zeng; Cai, Zhi‐Gang; Lv, Lei; Zou, Liu-he; Liu, X.-J.; Wu, Jun; Zhu, Zhiliang; Mao, Chi; Wang, Y.; Peng, Xin; Song, Bing; Li, X.-X.; Yu, Guohui

doi:10.1016/j.ijom.2018.07.006

Cited by 13 publications

(33 citation statements)

References 33 publications

(41 reference statements)

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“…12 Zhang et al conducted a long-term study to evaluate the effect of microvascular autologous submandibular gland transfer in 185 patients, which proved that it grants longterm improvement and symptomatic relief in cases of severe dry eye. 13 Our case is of a 5-year-old boy with severe bilateral dry eye. Vascularized submandibular gland transfers were performed for both eyes.…”

Section: Discussionmentioning

confidence: 95%

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Bilateral Microvascular Submandibular Gland Transfer with Implantation of Wharton's Duct in Superior Conjunctival Fornix: A Vision-Saving Procedure for Severe Dry Eye Disease

Sharma

Radhakrishnan

Rai

et al. 2022

Indian J Plast Surg

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Dry eye can initially cause mild symptoms of irritation and may rapidly progress to corneal scarring and blindness. Tear substitutes can only help for mild cases. With the advancement in microsurgical techniques, an option of transferring vascularized salivary glands has shown positive results. We present a case of a 5-year-old boy with congenital alacrimia with ocular surface damage. Vascularized autologous submandibular gland transfer was considered as a viable option for this patient. We performed the gland transfer in two separate stages for the two eyes (1 year 5 months apart). The patient was evaluated for up to 2 years for the right eye and for 7 months for the left eye. Dry eye workup showed drastic improvement (right > left). Biochemical analysis showed gradual transition to resemble that of natural tears. This procedure can result in significant symptomatic improvement and can be a promising treatment option for cases of severe dry eye.

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Section: Discussionmentioning

confidence: 95%

“…Zhang et al conducted a long-term study to evaluate the effect of microvascular autologous submandibular gland transfer in 185 patients, which proved that it grants long-term improvement and symptomatic relief in cases of severe dry eye. 13…”

Section: Discussionmentioning

confidence: 99%

Bilateral Microvascular Submandibular Gland Transfer with Implantation of Wharton's Duct in Superior Conjunctival Fornix: A Vision-Saving Procedure for Severe Dry Eye Disease

Sharma

Radhakrishnan

Rai

et al. 2022

Indian J Plast Surg

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“…SMG transplantation was performed as previously described 13 ( Figure 1 ). In brief, under general anesthesia, the SMG, including the branches of facial artery and vein and Wharton duct, was harvested from the submandibular triangle and transferred to the temporal region.…”

Section: Lar Submandibular and Minor Salivary Glandsmentioning

confidence: 99%

“…1 However, further instruction on choosing between these 2 surgical approaches is still vague. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Both SMG transplantation [2][3][4][5][6][7][8][9][10][11][12][13] and MSG transplantation [14][15][16][17][18][19][20] provide spontaneous, continuous, and endogenous lubrication with saliva as a tear substitute. Both treatments can improve severe symptoms and/or signs of dry eye, including Schirmer test score (ST), tear break-up time (TBUT), and some other ocular surface features.…”

mentioning

confidence: 99%

Submandibular Gland Transplantation vs Minor Salivary Glands Transplantation for Treatment of Dry Eye: A Retrospective Cohort Study

Zheng

Wang

et al. 2022

American Journal of Ophthalmology

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“…An increased dose is often adopted to address this problem, which unfortunately increases the risk of systemic side effects due to the conjunctival absorption of drug molecules by the blood through the nasolacrimal system [ 24 ]. Severe dry eyes can be treated by surgery, such as autologous gland duct transplantation, palpebral suture, amniotic membrane transplantation, and submandibular and labial gland transplantation [ 25 , 26 ]. Therefore, the early cure of dry eyes through control-released drugs is promising.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Cao

Wang

2022

Gels

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Dry eye disease (DED) is the most common clinical ocular surface disease. Given its multifactorial etiology, no consensus has been reached on the diagnosis criteria for dry eye disease. Topical drug administration remains the mainstay of treatment but is limited to the rapid clearance from the eye surface. To address these problems, hydrogel-based materials were designed to detect biomarkers or act as drug delivery systems by taking advantage of their good biocompatibility, excellent physical and mechanical properties, and long-term implant stability. Biosensors prepared using biocompatible hydrogels can be sensitive in diagnosing DED, and the designed hydrogels can also improve the drug bioavailability and retention time for more effective and long-term treatment. This review summarizes recent advances in the use of hydrogels for diagnosing and treating dry eye, aiming to provide a novel reference for the eventual clinical translation of hydrogels in the context of dry eye disease.

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Factors influencing the long-term results of autologous microvascular submandibular gland transplantation for severe dry eye disease

Cited by 13 publications

References 33 publications

Bilateral Microvascular Submandibular Gland Transfer with Implantation of Wharton's Duct in Superior Conjunctival Fornix: A Vision-Saving Procedure for Severe Dry Eye Disease

Bilateral Microvascular Submandibular Gland Transfer with Implantation of Wharton's Duct in Superior Conjunctival Fornix: A Vision-Saving Procedure for Severe Dry Eye Disease

Submandibular Gland Transplantation vs Minor Salivary Glands Transplantation for Treatment of Dry Eye: A Retrospective Cohort Study

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

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