Factors Influencing the Delivery Efficiency of Cancer Nanomedicines

Abstract

The superiority of nanomedicine over conventional medicines in the treatment of cancer has gained immediate recognition worldwide. As traditional cancer therapies are nonspecific and detrimental to healthy cells, the ability of nanomedicine to release drugs to target tumor cells specifically instead of healthy cells has brought new hope to cancer patients. This review focuses on the effects of various factors of nanoparticles such as transport, concentration in cells, tumor microenvironment, interaction with protein, penetration, uptake by tumor cells, cancer cell mutations, and intracellular trafficking of the nanoparticle. Besides the history of nanomedicine, future perspectives of nanomedicines are also explored in this text.

Advances of medical nanorobots for future cancer treatments

“…Scaling up the development and production of large numbers of nanorobots for clinical cancer treatments is a formidable challenge due to the complex and time-consuming nature of the manufacturing processes. This scalability issue involves several key aspects that need to be addressed, including production techniques, cost, quality control, and supply chain management [328].…”

Delivery process and effective design of vectors for cancer therapy

“…[66][67][68] However, due to the complex environment of tumor tissues and cells, a single stimulation mode or simple functional output can no longer meet the needs of polymer materials. Therefore, the development of novel stimulation conditions, 69 diversified stimulation methods, and functional responses with logical control has become the focus of research on the construction of stimuli-responsive polymer systems. 65,70 Li et al 71 are committed to the construction of intelligent nano-drug delivery systems based on the host-guest recognition of cyclodextrins (Fig.…”

Virus-Based Supramolecular Structure and Materials: Concept and Prospects

“…Direct injection of replication-competent virus will destroy the host cells. − Therefore, VLPs serving as alternatives for construction of drug delivery systems have been developed. Virus assembly such as TMV assembly is induced by the origin of assembly (OAS).…”