Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands

Huang, Min-Xian; Ma, Dan; Sun, Kaihua; Yu, Guanzhen; Guo, Chao; Gao, Feng

doi:10.1016/s0901-5027(97)80008-2

Cited by 150 publications

(119 citation statements)

References 7 publications

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“…[2][3][4][5][6]10 This is comparable to our 5-and 10-year survival of 78% and 55%, respectively. Consistent with studies by Fordice 4 et al, Spiro,11 and Gomez et al, 12 who demonstrated decreased survival in patients with cervical nodal metastasis, our data showed a substantial decrease in survival.…”

Section: Resultssupporting

confidence: 80%

Patterns of recurrence and survival of head and neck adenoid cystic carcinoma after definitive resection

et al. 2009

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Objectives/Hypothesis: To determine factors impacting recurrence and long-term survival of adenoid cystic carcinoma (ACC) of the head and neck after definitive resection.Study Design: Retrospective cohort study at an academic tertiary care hospital.Methods: Patients with ACC of the head and neck treated at our institution were reviewed. Those not receiving surgery, or with metastatic disease were excluded. Clinicopathological data on each patient was collected.Results: Of 113 patients identified with ACC, 99 were studied. The overall median survival for the cohort was 71 months (mean AE standard deviation, 94 AE 79 months). American Joint Committee on Cancer (AJCC) tumor stage and N stage were independent predictors of survival on multivariate analysis. Mean overall survival (P ¼ .001) and time to recurrence (P ¼ .006) were lower for patients with cervical lymph node positive disease (Nþ). Tumors in major salivary glands were associated with longer survival (P ¼ .027). The overall recurrence rate was 53%, with a mean time to recurrence of 63 AE 64 months. The presence of lymphovascular invasion predicted recurrence on multivariate analysis (P ¼ .002), with advanced tumor stage predicting early ( 36 months) recurrence (P ¼ .013). Among the 57 patients who received adjuvant radiation therapy, there was no difference in survival, rate of recurrence, or time to recurrence, when compared to patients treated with surgery alone.Conclusions: Clinicopathological variables including AJCC tumor stage, tumor site, presence of Nþ disease, and lymphovascular invasion may be used as prognostic factors in predicting survival and recurrence after a definitive resection of ACC of the head and neck.

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Section: Resultssupporting

confidence: 80%

Patterns of recurrence and survival of head and neck adenoid cystic carcinoma after definitive resection

et al. 2009

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“…It is a slowly growing but highly invasive cancer with a high recurrence rate. Hematogenous spread occurs often in the course of the disease [11,12]. The prognostic factors of AdCC depend Fig.…”

Section: Dıscussionmentioning

confidence: 99%

Unique presentation of adenoid cystic carcinoma in postcricoid region: a case report and review of the literature

Saraydaroğlu

Çoşkun

Kasap

2011

Head and Neck Pathol

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Malignant tumors of minor salivary glands are uncommon, representing only 2-4% of all head and neck malignancies. In the larynx, minor salivary gland tumors rarely occur and constitute less than 1% of laryngeal tumors. Most of the minor salivary gland tumors arise in the subglottis; however, they can also occur in the supraglottis in the false vocal cords, aryepiglottic folds, and caudal aspect of the epiglottis. The most common type of malignant minor salivary gland tumor is adenoid cystic carcinoma. In the last 20 years, only 40 cases of adenoid cystic carcinoma arising in variable locations of the larynx have been reported in the English language literature. We present a case of adenoid cystic carcinoma of the larynx arising in the inter-arytenoid and postcricoid region in a 54-year-old woman. To our knowledge, this is the first case of adenoid cystic carcinoma arising in this particular region of the larynx.

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“…The nature of the primary tumour, location, histomorphology, and its tendency to metastasize to distant sites, positive margins at the surgical site, determine the survival rate [14].…”

Section: Discussionmentioning

confidence: 99%

Adenoid Cystic Carcinoma of the Buccal Mucosa: A Case Report with Review of Literature

Santhanam¹,

Aravindhan

2014

JCDR

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A 48-year-old female patient presented with complaint of a swelling in the left cheek, in relation to left upper back tooth region. The swelling was present since 1 year and it had arisen as a small one, after extraction of a decayed left upper back tooth. History revealed that the swelling had increased gradually to attain its present size and that it was not associated with pain. There was no relevant medical, surgical or personal history. On extra oral examination, there was no evidence of erythema, ulceration or ecchymosis. Single left submandibular lymph node that was mobile, firm, non-tender and of size 0.5x0.5 cm, was palpable. Intra oral examination revealed a single localized dome shaped swelling of size 2x3 cm in the left buccal mucosa, in relation to 27 region, which extended posteriorly till the faucial pillars of the tonsils [Table/ Fig-1]. The mucosa which overlay the swelling was erythematous in nature and its surface was smooth. There was no surface discharge, the swelling was firm in consistency and it was nontender. The swelling was fixed to the underlying tissue and the area which surrounded the swelling, appeared to be normal. Clinical differential diagnosis included benign mesenchymal neoplasms, reactive or inflammatory conditions of minor salivary glands, benign or low grade malignant tumours of salivary gland origin, and metastatic tumour deposits of distant site. An orthopantomograph was taken and it revealed no bony changes in the maxilla or the mandible. Lesion was excised in toto, it was Dentistry Section aBstRaCt Minor salivary gland neoplasms of the buccal mucosa are relatively uncommon. Adenoid cystic carcinoma (ACC), a well-defined entity, occurs most of the times in the parotid, submandibular glands and palate, as far as the intraoral site is concerned. Adenoid cystic carcinoma tends to have an indolent, extended clinical course with wide local infiltration and late distant metastases. We are presenting a case of an adenoid cystic carcinoma of the buccal mucosa in a 48-year-old female patient.[table/ Fig-1]: Clinical picture depicting a mass of the buccal mucosa

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Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands

Cited by 150 publications

References 7 publications

Patterns of recurrence and survival of head and neck adenoid cystic carcinoma after definitive resection

Patterns of recurrence and survival of head and neck adenoid cystic carcinoma after definitive resection

Unique presentation of adenoid cystic carcinoma in postcricoid region: a case report and review of the literature

Adenoid Cystic Carcinoma of the Buccal Mucosa: A Case Report with Review of Literature

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