Factors influencing survival in acinic cell carcinoma: A retrospective survival analysis of 2061 patients

Biron, Vincent L.; Lentsch, Eric J.; Gerry, Daniel; Bewley, Arnaud F.

doi:10.1002/hed.23686

Cited by 37 publications

(52 citation statements)

References 31 publications

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“…Most cases of metastatic papillary thyroid carcinoma should readily be excluded due to positive TTF-1 and thyroglobulin. surgical resection alone gives excellent results and adjuvant therapy may be of limited benefi t [ 7 ]. A Japanese immunohistochemical study of geminin and Ki-67, correlated to pathological T stage, lymphatic and blood vessel infi ltration, showed the expression of geminin to be strongly associated with poor prognosis.…”

Section: Differential Diagnosismentioning

confidence: 98%

Acinic Cell Carcinoma

Hellquist

Skálová

2014

Histopathology of the Salivary Glands

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Section: Differential Diagnosismentioning

confidence: 98%

Acinic Cell Carcinoma

Hellquist

Skálová

2014

Histopathology of the Salivary Glands

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“…Nodal metastasis is really uncommon at the time of diagnosis [26]. AcCC is less common in minor salivary glands and comprises only 9% according to SEER database [30]. AcCC of minor salivary glands mostly occur in buccal mucosa and upper lip in contrast to other types of minor salivary glands which mostly occur in palate [31,32].…”

Section: Acinic Cell Carcinomamentioning

confidence: 99%

Salivary Gland Cancers: A Survey through History, Classifications and Managements

Khosravi¹,

Bagherihagh²,

Saeedi³

et al. 2017

Diagnosis and Management of Head and Neck Cancer

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In this chapter, we are going to discuss about salivary glands cancers, their clinical manifestations and categories, pathogenesis, diagnosis and treatment. We will go through details in each part in both clinical and surgical aspects based on recently prominent published studies and research in prestigious journals. After a short review on clinical features, epidemiology, pathogenesis, diagnosis and treatment, we will show staging and tumor node metastasis (TNM) classiication of major salivary gland tumors and also basic principles of approach to salivary gland cancers. A litle will be explained about basic surgical procedures for removal of cancers and benign tumors.

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“…The treatment modalities reported including surgical resection, radiotherapy and chemotherapy, and combined therapies with variable results [3]. However, among all salivary gland cancers, HNACC has a relatively favourable prognosis [5]. It is worth noting that, based on some researchers' institutional experience, HNACC is classi ed as a low-grade cancer regardless of its clinicopathologic features [6].…”

Section: Introductionmentioning

confidence: 99%

Head & neck acinar cell carcinoma: a population-based study using the seer registry

Yibulayin

Feng

Wang

et al. 2020

Preprint

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Background: to explore the clinicopathologic characteristics, treatment and prognostic factors of head and neck acinar cell carcinoma (HNACC) comprehensively. Methods: A population-based study was conducted using data from the Surveillance, Epidemiology, and End Results database (1975- 2016). Overall survival (OS) and HNACC-specific survival of patients with different clinicopathologic variables were compared using the Kaplan-Meier method and Cox multivariate regression. Results: A total of 2624 primary HNACC cases (1052 males, 1572 females) were identified. There was a significant difference in gender distribution. Among the total cohort, 2416 cases originated from salivary glands, including 2325 parotid gland ACC cases. Regardless of confounding factors, the 10-year and 20-year disease-specific survival (DSS) was 93.6% and 90%, respectively. Surgery was favourably associated with better DSS and OS [HR = 0.13, P = 0.0092 and HR = 0.23, P = 0.0203]. Gender was the only demographic independent prognostic factor for both DSS and OS [male vs female, HR = 3.3, P = 0.0028 for DSS; HR = 2.44, P = 0.0376 for OS]. Higher pathological grade was adversely associated with DSS and OS [Grade II, HR= 4.03, P = 0.0444; Grade III + IV, HR = 35.64, P = 0.0000 for DSS; Grade III + IV, HR = 4.49, P = 0.0000 for OS, Grade I as reference]. In addition, TNM/AJCC stage was commonly associated with prognosis. Conclusion: Surgery was the only favourable prognostic indicator for both DSS and OS. Gender, age, pathological differentiation and TNM/AJCC stage were independent prognostic factors for survival.

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Factors influencing survival in acinic cell carcinoma: A retrospective survival analysis of 2061 patients

Abstract: Our results suggest that histologic grade is a stronger predictor of survival than TNM classification, survival after surgical resection alone is excellent, and adjuvant radiation may be of limited benefit

Cited by 37 publications

References 31 publications

Acinic Cell Carcinoma

Acinic Cell Carcinoma

Salivary Gland Cancers: A Survey through History, Classifications and Managements

Head & neck acinar cell carcinoma: a population-based study using the seer registry

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Factors influencing survival in acinic cell carcinoma: A retrospective survival analysis of 2061 patients

Abstract: Our results suggest that histologic grade is a stronger predictor of survival than TNM classification, survival after surgical resection alone is excellent, and adjuvant radiation may be of limited benefit

Cited by 37 publications

References 31 publications

Acinic Cell Carcinoma

Acinic Cell Carcinoma

Salivary Gland Cancers: A Survey through History, Classifications and Managements

Head &amp; neck acinar cell carcinoma: a population-based study using the seer registry

Contact Info

Product

Resources

About

Head & neck acinar cell carcinoma: a population-based study using the seer registry