Factors influencing subjective quality of life in patients with schizophrenia and other mental disorders: A pooled analysis

Abstract

Subjective quality of life (SQOL) is an important outcome in the treatment of patients with schizophrenia. However, there is only limited evidence on factors influencing SQOL, and little is known about whether the same factors influence SQOL in patients with schizophrenia and other mental disorders. This study aimed to identify the factors associated with SQOL and test whether these factors are equally important in schizophrenia and other disorders. For this we used a pooled data set obtained from 16 studies that had used either the Lancashire Quality of Life Profile or the Manchester Short Assessment of Quality of Life for assessing SQOL. The sample comprised 3936 patients with schizophrenia, mood disorders, and neurotic disorders. After controlling for confounding factors, within-subject clustering, and heterogeneity of findings across studies in linear mixed models, patients with schizophrenia had more favourable SQOL scores than those with mood and neurotic disorders. In all diagnostic groups, older patients, those in employment, and those with lower symptom scores had higher SQOL scores. Whilst the strength of the association between age and SQOL did not differ across diagnostic groups, symptom levels were more strongly associated with SQOL in neurotic than in mood disorders and schizophrenia. The association of employment and SQOL was stronger in mood and neurotic disorders than in schizophrenia. The findings may inform the use and interpretation of SQOL data for patients with schizophrenia.

Consumer satisfaction, quality of life and distress with regard to social function and gender in severe mental illness

“…Similarly, the previously mentioned Nysam study found no significant difference in this regard [53]. This finding is in line with, for instance, a pooled analysis of 16 studies (using MANSA or LQOLP) to study factors influencing subjective quality of life in patients with schizophrenia and other mental disorders, where it was found that gender did not have an effect [55]. Likewise, using the LQOLP instrument, it was found in a study with schizophrenia patients in the Netherlands that gender was not related to general quality of life [56].…”

The Relationship Between Consumer Insight and Provider-Consumer Agreement Regarding Consumer’s Quality of Life

“…The limited agreement between consumers and providers perspectives on consumers' QoL is important due to its putative relevance for the quality of the therapeutic relationship which is an important component of effective mental health care (Priebe et al 2005(Priebe et al , 2010Couture et al 2006;Lasalvia and Ruggeri 2007). A widely accepted definition of the therapeutic alliance characterizes it in terms of three core dimensions: a positive emotional relationship, agreement with regard to tasks, and consensus with regard to the goals of therapy (Bordin 1979;Horvath and Bedi 2002).…”

Psychopathological Symptoms and Satisfaction with Mental Health in Patients with Schizophrenia

“…As well as the 5 symptom sub-scales, age and gender were included in the analysis as research has shown that age tends to be positively related to global life satisfaction [4] and gender may also play a role [5, 6]. …”

“…We conducted an individual patient data meta-analysis to identify which psychopathological symptoms are associated with satisfaction with mental health. We also explored the influence of age and gender because previous research has suggested that age may be positively linked to life satisfaction [4], whilst findings concerning gender have been mixed, with studies coming to opposing conclusions regarding which gender tends to be associated with a higher life satisfaction [5, 6]. …”