Purpose-Scleroderma (SSc) is rare, and few studies have examined self-efficacy in persons with the disease. Self-efficacy is one precursor that has been shown to initiate changes in behavior when managing chronic disease. The objective of this study was to explore the levels of selfefficacy in persons with SSc, compare self-efficacy in persons with limited or diffuse SSc, and determine correlations between self-efficacy, physical function, and psychological variables.Methods-Sixty-two participants with SSc completed measures assessing self-efficacy, depression, fatigue, pain, hand function, and activity limitations. The mean age of participants was 52.9 years. The mean educational level was 15.8 years. Sixty-seven percent were married, and 87.1% were women. Thirty participants had diffuse SSc, 27 had limited SSc, and 5 were unclassified.Results-The only significant differences between the two disease subtypes were in hand function and self-efficacy function subscale scores. Total self-efficacy scores significantly correlated with marital status, employment, self-reported health, depression, functional ability, fatigue, pain, and hand function. Similarly, self-efficacy function scale scores significantly correlated with employment, self-reported health, functional ability, pain, and hand function. Selfefficacy pain scale scores significantly correlated with fatigability. The self-efficacy other scale scores significantly correlated with depression and fatigability. Participants with higher levels of pain and depression, more fatigue, more general disability, and more hand disability had lower self-efficacy. Conclusion-Self-efficacy correlates with physical function and psychological variables, and could predict how patients manage their health. Self-efficacy may increase through participation in educational programs focusing on self-management of these variables.