Factors influencing participation in an Ebola vaccine trial among front-line workers in Guinea

Grantz, Kyra H.; Claudot, Pauline; Kambala, Micky; Kouyaté, Mariama; Soumah, Aboubacar; Boum, Yap; Juan-Giner, Aitana; Jemmy, Jean-Paul; Cummings, Derek A. T.; Grais, Rebecca F.

doi:10.1016/j.vaccine.2019.09.094

Cited by 15 publications

(10 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among those participants who said they would not accept a COVID-19 vaccine, we found that their primary concerns were highly specific to the vaccine development process, to issues relating to the rapidity of the vaccine trials & the novelty of mRNA based vaccines; as well as to the relative absence of knowledge about the long-term effects and safety including in pregnancy and breastfeeding. Whilst the seemingly low penetration of misinformation in our corpus of text may have been biased downwards by the limited representativeness of our sample, empirical social scientific research on rumours, hesitancy and trust in medical research across different contexts has shown similar results [34]. In the context of the concerns of this study's participants, COVID-19 vaccine hesitancy appeared to be framed by legitimate concerns about the perceived unavailability of substantive scientific data to support claims that the vaccines were safe and (possibly to a lesser degree) effective.…”

Section: Discussionmentioning

confidence: 89%

Vaccine Confidence and Hesitancy at the start of COVID-19 vaccine deployment in the UK: An embedded mixed-methods study

Brindle

Rogers

Eggo

et al. 2021

Preprint

View full text Add to dashboard Cite

Introduction Approval for the use of COVID-19 vaccines has been granted in a number of countries but there are concerns that vaccine uptake may be low amongst certain groups. Methods This study used a mixed methods approach based on online survey and an embedded quantitative/qualitative design to explore perceptions and attitudes that were associated with intention to either accept or refuse offers of vaccination in different demographic groups during the early stages of the UK's mass COVID-19 vaccination programme (December 2020). Analysis used multivariate logistic regression, structural text modelling and anthropological assessments. Results Of 4,535 respondents, 85% (n=3,859) were willing to have a COVID-19 vaccine. The rapidity of vaccine development and uncertainties about safety were common reasons for COVID-19 vaccine hesitancy. There was no evidence for the widespread influence of mis-information, although broader vaccine hesitancy was associated with intentions to refuse COVID-19 vaccines (OR 20.60, 95% CI 14.20-30.30, p<0.001). Low levels of trust in the decision-making (OR 1.63, 95% CI 1.08, 2.48, p=0.021) and truthfulness (OR 8.76, 95% CI 4.15-19.90, p<0.001) of the UK government were independently associated with higher odds of refusing COVID-19 vaccines. Compared to political centrists, conservatives and liberals were respectively more (OR 2.05, 95%CI 1.51-2.80, p<0.001) and less (OR 0.30, 95% CI 0.22-0.41, p<0.001) likely to refuse offered vaccines. Those who were willing to be vaccinated cited both personal and public protection as reasons, with some alluding to having a sense of collective responsibility. Conclusion Dominant narratives of COVID-19 vaccine hesitancy are misconceived as primarily being driven by misinformation. Key indicators of UK vaccine acceptance include prior behaviours, transparency of the scientific process of vaccine development, mistrust in science and leadership and individual political views. Vaccine programmes should leverage the sense of altruism, citizenship and collective responsibility that motivated many participants to get vaccinated.

show abstract

Section: Discussionmentioning

confidence: 89%

Vaccine Confidence and Hesitancy at the start of COVID-19 vaccine deployment in the UK: An embedded mixed-methods study

Brindle

Rogers

Eggo

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Among those participants who said they would not accept a COVID-19 vaccine, we found that their primary concerns were highly specific to the vaccine development process, to issues relating to the rapidity of the vaccine trials & the novelty of mRNA-based vaccines; as well as to the relative absence of knowledge about the long-term effects and safety including in pregnancy and breastfeeding. Whilst the seemingly low penetration of misinformation in our corpus of text may have been biased downwards by the limited representativeness of our sample, empirical social scientific research on rumors, hesitancy and trust in medical research across different contexts has shown similar results ( 34 ). In the context of the concerns of this study's participants, COVID-19 vaccine hesitancy appeared to be framed by legitimate concerns about the perceived unavailability of substantive scientific data to support claims that the vaccines were safe and (possibly to a lesser degree) effective.…”

Section: Discussionmentioning

confidence: 97%

Vaccine Confidence and Hesitancy at the Start of COVID-19 Vaccine Deployment in the UK: An Embedded Mixed-Methods Study

Brindle

Rogers

Eggo

et al. 2021

Front. Public Health

View full text Add to dashboard Cite

Background: Approval for the use of COVID-19 vaccines has been granted in a number of countries but there are concerns that vaccine uptake may be low amongst certain groups.Methods: This study used a mixed methods approach based on online survey and an embedded quantitative/qualitative design to explore perceptions and attitudes that were associated with intention to either accept or refuse offers of vaccination in different demographic groups during the early stages of the UK's mass COVID-19 vaccination programme (December 2020). Analysis used multivariate logistic regression, structural text modeling and anthropological assessments.Results: Of 4,535 respondents, 85% (n = 3,859) were willing to have a COVID-19 vaccine. The rapidity of vaccine development and uncertainties about safety were common reasons for COVID-19 vaccine hesitancy. There was no evidence for the widespread influence of mis-information, although broader vaccine hesitancy was associated with intentions to refuse COVID-19 vaccines (OR 20.60, 95% CI 14.20–30.30, p < 0.001). Low levels of trust in the decision-making (OR 1.63, 95% CI 1.08, 2.48, p = 0.021) and truthfulness (OR 8.76, 95% CI 4.15–19.90, p < 0.001) of the UK government were independently associated with higher odds of refusing COVID-19 vaccines. Compared to political centrists, conservatives and liberals were, respectively, more (OR 2.05, 95%CI 1.51–2.80, p < 0.001) and less (OR 0.30, 95% CI 0.22–0.41, p < 0.001) likely to refuse offered vaccines. Those who were willing to be vaccinated cited both personal and public protection as reasons, with some alluding to having a sense of collective responsibility.Conclusion: Dominant narratives of COVID-19 vaccine hesitancy are misconceived as primarily being driven by misinformation. Key indicators of UK vaccine acceptance include prior behaviors, transparency of the scientific process of vaccine development, mistrust in science and leadership and individual political views. Vaccine programmes should leverage the sense of altruism, citizenship and collective responsibility that motivated many participants to get vaccinated.

show abstract

“…Different response teams (eg, contact tracing and vaccination teams) vied to demonstrate their unique contributions and retain high-paying positions. 35 …”

Section: Resultsmentioning

confidence: 99%

‘Learn from the lessons and don’t forget them’: identifying transferable lessons for COVID-19 from meningitis A, yellow fever and Ebola virus disease vaccination campaigns

et al. 2021

View full text Add to dashboard Cite

IntroductionCOVID-19 vaccines are now being distributed to low- and middle-income countries (LMICs), with global urgency surrounding national vaccination plans. LMICs have significant experience implementing vaccination campaigns to respond to epidemic threats but are often hindered by chronic health system challenges. We sought to identify transferable lessons for COVID-19 vaccination from the rollout of three vaccines that targeted adult groups in Africa and South America: MenAfriVac (meningitis A); 17D (yellow fever) and rVSV-ZEBOV (Ebola virus disease).MethodsWe conducted a rapid literature review and 24 semi-structured interviews with technical experts who had direct implementation experience with the selected vaccines in Africa and South America. We identified barriers, enablers, and key lessons from the literature and from participants’ experiences. Interview data were analysed thematically according to seven implementation domains.ResultsParticipants highlighted multiple components of vaccination campaigns that are instrumental for achieving high coverage. Community engagement is an essential and effective tool, requiring dedicated time, funding and workforce. Involving local health workers is a key enabler, as is collaborating with community leaders to map social groups and tailor vaccination strategies to their needs. Vaccination team recruitment and training strategies need to be enhanced to support vaccination campaigns. Although recognised as challenging, integrating vaccination campaigns with other routine health services can be highly beneficial if well planned and coordinated across health programmes and with communities.ConclusionAs supplies of COVID-19 vaccines become available to LMICs, countries need to prepare to efficiently roll out the vaccine, encourage uptake among eligible groups and respond to potential community concerns. Lessons from the implementation of these three vaccines that targeted adults in LMICs can be used to inform best practice for COVID-19 and other epidemic vaccination campaigns.

show abstract

Factors influencing participation in an Ebola vaccine trial among front-line workers in Guinea

Cited by 15 publications

References 37 publications

Vaccine Confidence and Hesitancy at the start of COVID-19 vaccine deployment in the UK: An embedded mixed-methods study

Vaccine Confidence and Hesitancy at the start of COVID-19 vaccine deployment in the UK: An embedded mixed-methods study

Vaccine Confidence and Hesitancy at the Start of COVID-19 Vaccine Deployment in the UK: An Embedded Mixed-Methods Study

‘Learn from the lessons and don’t forget them’: identifying transferable lessons for COVID-19 from meningitis A, yellow fever and Ebola virus disease vaccination campaigns

Contact Info

Product

Resources

About