Factors Influencing Long-Term Survival After Lung Metastasectomy

Pulmonary metastases from epithelial tumours: late results of surgical treatment☆

“…Some previous studies indicated histology subtype and differentiation grading as prognostic factors too [4,9,18,19]. We could not confirm the prognostic value of either histology or grading of the primary tumour.…”

“…Other authors have reported 5-year and 10-year survivals between 10% and 63.7% and between 8.1% and 33%, respectively [4,8,10,12,15,[17][18][19]. Local recurrence after pulmonary metastasectomy is a crucial problem during follow-up and the indication for re-operation is sometimes controversial.…”

Surgery for metastatic melanoma

“…Of all metastatic visceral sites in melanoma, surgery for lung lesions leaving no residue and with free margins (i.e., complete resection of pulmonary metastases) offers the best survival statistics [8,25,26]. An aggressive surgical approach in some patients with these metastases has been demonstrated to prolong survival, as indicated by a number of reports [26].…”

“…An aggressive surgical approach in some patients with these metastases has been demonstrated to prolong survival, as indicated by a number of reports [26]. Median survival of unresected pulmonary metastases is 10 to 11 months, rising to 19 months with complete resection [8,13,22].…”

“…Most series, however, do not employ this criterion [22] since patients usually are resected prior to the elapse of the doubling time. Long-term survivors who have not only solitary metastases resected but also multiple metastases (not exceeding four) have been observed in many accounts [22,23,25,26]. Some authors have found that the number of diagnosed nodules did not correlate with the survival rate [5,8].…”