Pulmonary metastases from epithelial tumours: late results of surgical treatment☆

Rena, Ottavio; Papalia, Esther; Oliaro, A; Filosso, Pier Luigi; Ruffini, Enrico; Maggi, G; Casadio, Caterina

doi:10.1016/j.ejcts.2006.04.032

Cited by 29 publications

(29 citation statements)

References 22 publications

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“…The intrathoracic recurrence rate after pulmonary metastasectomy has been reported to be 16-53% by open thoracotomy [16][17][18][19][20][21] and 18-49% by VATS [1][2][3][4][5], showing similar outcomes between these two procedures. In this Mediastinal lymph node recurrence 1 *One case of operation-related death was excluded study, we were unable to conduct a simple comparison because recurrence data were collected retrospectively and patients were not on a prescribed surveillance schedule; yet the intrathoracic recurrence rate was 46.2%, a local control rate similar to those in previous reports.…”

Section: Discussionmentioning

confidence: 76%

“…Regarding prognosis, a simple comparison cannot be done among reports because of variation with primary tumor site; nonetheless overall 5-year survival rate following pulmonary resection by thoracotomy has been reported to be 30-54% [16][17][18][19][20][21][24][25][26][27]. To date, there are only a few reports on the outcome of VATS for pulmonary metastases.…”

Section: Discussionmentioning

confidence: 98%

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Evaluation of video-assisted thoracoscopic surgery for pulmonary metastases: 11-years of experience

et al. 2008

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 98%

Evaluation of video-assisted thoracoscopic surgery for pulmonary metastases: 11-years of experience

et al. 2008

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“…According to the presence of three risk factors, namely, completeness of resection, number of metastases, and DFI, the prognostic grouping system proposed by the International Registry of Lung Metastases was supported by others. 5,6 Infl uence of Pulmonary and Mediastinal Lymph Node Involvement Is pulmonary metastasectomy applicable to patients with pulmonary or mediastinal lymph node involvement? Should lymph node dissection be routinely performed along with pulmonary metastasectomy?…”

Section: Introductionmentioning

confidence: 99%

Current status of pulmonary metastasectomy from primary epithelial tumors

2009

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The resection of pulmonary metastases can prolong the survival of selected patients and its therapeutic value is now accepted. The criteria for eligibility have also evolved. We reviewed the recent literature on pulmonary metastasectomy for various epithelial primary tumors and tried to establish better prognostic indicators for its surgical application. In addition to the welldefined requisites for pulmonary metastasectomy, other requirements include the absence of mediastinal lymph node involvement, a limited number of pulmonary metastatic lesions, a long disease-free interval, small metastasis, and no elevation of tumor markers, although the clinical importance of each factor varies among the primary tumors. On the other hand, with the development of video-assisted thoracoscopic surgery (VATS) and advances in thoracic imaging technology, VATS metastasectomy might become an accepted treatment for metastatic nodules located in the periphery of the lung, which can be easily removed by a wedge resection. Repeat surgery is also possible during follow-up after VATS.

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“…to be 47.4% and 43%, respectively. [67] Among the 5206 cases of the internationally registered patients with lung metastases, the 5, 10 and 15-years survival rates after complete resection were 36%, 26%, and 22%, respectively. [1]…”

Section: Discussionmentioning

confidence: 99%

Surgical approach and outcomes for treatment of pulmonary metastases

Su¹,

Ma²,

Zhang³

et al. 2013

Ann Thorac Med

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AIMS:To investigate the surgical approach and outcomes, as well as prognostic factors for pulmonary metastasectomy.METHODS:Clinical data of 201 patients treated by pulmonary metastasectomy between January 1990 and December 2009 were retrospectively reviewed. One hundred thirty three patients were received an approach of thoracotomy while 68 with video-assisted thoracoscopic surgery (VATS). There were 54 lobectomies, 139 wedge resections and 8 pneumonectomies. Hilar or mediastinal lymph nodes dissection or sampling was carried out in 38 patients with lobectomy. The Kaplan-Meier method was used for the survival analysis. Cox proportional hazards model was used for multivariate analysis.RESULTS:The 5 years survival rate of patients after metastasectomy was 50.5%, and the median survival time was 65.9 months. The median survival time of patients with hilar or mediastinal lymph nodes metastasis was 23 months. By univariate analysis, significant prognostic factors included disease-free interval (DFI), number of metastases, number of affected lobe, surgical approach (open vs. VATS) and pathology types. DFI, number of metastases, and pathology types were revealed by Cox multivariate analysis as independent prognostic factors.CONCLUSION:Surgical resection of pulmonary metastases is safe and effective. Palpation of the lung is still seen as necessary to detect the occult nodule. More accurate and sensitive pre-operative mediastinal staging are required.

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Pulmonary metastases from epithelial tumours: late results of surgical treatment☆

Cited by 29 publications

References 22 publications

Evaluation of video-assisted thoracoscopic surgery for pulmonary metastases: 11-years of experience

Evaluation of video-assisted thoracoscopic surgery for pulmonary metastases: 11-years of experience

Current status of pulmonary metastasectomy from primary epithelial tumors

Surgical approach and outcomes for treatment of pulmonary metastases

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