Factors influencing left atrial volume in a population with preserved ejection fraction: Left ventricular diastolic dysfunction or clinical factors?

Lee, Seitetsu L.; Daimon, Masao; Nakao, Tomoko; Singer, Daniel E.; Shinozaki, Tomohiro; Kawata, Takayuki; Kimura, Kôichi; Hirokawa, Megumi; Kato, Tomoko S.; Mizuno, Yoshiko; Watanabe, Masafumi; Yatomi, Yutaka; Yamazaki, Tsutomu; Komuro, Issei

doi:10.1016/j.jjcc.2016.02.003

Cited by 10 publications

(10 citation statements)

References 42 publications

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“…Major limitation of the present study is that we could not assess all echocardiographic parameters required for the diagnosis of LV diastolic dysfunction in the latest American Society of Echocardiography guideline. Several importance parameters in assessing LV diastolic function, such as LA volume [35,36], were not measured in all study participants, and we used old formula (Teichholtz formula) in the present study because echocardiographic data were collected by previous guidelines. Therefore, further studies are needed to confirm the relationship between subclinical LV change and prehypertension and hypertension in patient with DM.…”

Section: Characteristics Normal Bp Prehypertension Hypertensionmentioning

confidence: 99%

The optimal cut-off of blood pressure related to left ventricular diastolic dysfunction and remodeling in Asian diabetic patients

Jung

Park

Ryoo

et al. 2018

Journal of Cardiology

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Section: Characteristics Normal Bp Prehypertension Hypertensionmentioning

confidence: 99%

The optimal cut-off of blood pressure related to left ventricular diastolic dysfunction and remodeling in Asian diabetic patients

Jung

Park

Ryoo

et al. 2018

Journal of Cardiology

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“…Therefore, the aims of the present study were to determine (1) the influence of endogenous estrogens on the angiotensin‐forming pathways in cardiac myocytes (CMs) and non‐myocyte (NCMs) cell membranes from normotensive and hypertensive hearts and (2) to assess the relationships between intracellular RAS enzymatic activities and cardiac function and structure. Given that diastolic dysfunction can manifest in postmenopausal women without overt elevations in blood pressure (BP) (Kane et al, ; Lee et al, ), we used ovariectomized and sham‐operated adult WKY and SHR to determine the modulatory role of estrogens on intracellular Ang II and angiotensin‐1‐7 (Ang‐1‐7) forming enzymatic activity and on gene expression of RAS‐related components in cardiac cells.…”

Section: Introductionmentioning

confidence: 99%

Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR

Ahmad

Sun

Lin

et al. 2017

Journal Cellular Physiology

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The relatively low efficacy of ACE-inhibitors in the treatment of heart failure in women after estrogen loss may be due to their inability to reach the intracellular sites at which angiotensin (Ang) II is generated and/or the existence of cell-specific mechanisms in which ACE is not the essential processing pathway for Ang II formation. We compared the metabolic pathway for Ang II formation in freshly isolated myocytes (CMs) and non-myocytes (NCMs) in cardiac membranes extracted from hearts of gonadal-intact and ovariectomized (OVX) adult WKY and SHR rats. Plasma Ang II levels were higher in WKY vs. SHR (strain effect: WKY: 62 ± 6 pg/ml vs. SHR: 42 ± 9 pg/ml; p < 0.01), independent of OVX. The enzymatic activities of chymase, ACE, and ACE2 were higher in NCMs versus CMs, irrespective of whether assays were performed in cardiac membranes from WKY or SHR or in the presence or absence of OVX. E2 depletion increased chymase activity, but not ACE activity, in both CMs and NCMs. Moreover, cardiac myocyte chymase activity associated with diastolic function in WKYs and cardiac structure in SHRs while no relevant functional and structural relationships between the classic enzymatic pathway of Ang II formation by ACE or the counter-regulatory Ang-(1-7) forming path from Ang II via ACE2 were apparent. The significance of these novel findings is that targeted cell-specific chymase rather than ACE inhibition may have a greater benefit in the management of HF in women after menopause.

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Section: Limitationsmentioning

confidence: 99%

“…30 Although prognostically relevant, some other factors that have been described to influence left atrial size such as adipositas or low blood haemoglobin were not adjusted for in our analysis. 31,32 Summary Knowledge about the assessment of cardiac function using CMR at 3 Tesla in patients suffering from AIS is limited. Comparing standard segmented cine SSFP sequences and accelerated CRT sequences, the latter showed a sufficient level of agreement for the determination of key functional parameters but requires determination of specific normal values with regard to spatial and temporal resolution.…”

Section: Limitationsmentioning

confidence: 99%

Evaluation of left ventricular function in patients with acute ischaemic stroke using cine cardiovascular magnetic resonance imaging

et al. 2020

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Aims Heart failure (HF) is frequent in patients with acute ischaemic stroke (AIS) and associated with higher morbidity and mortality. Assessment of cardiac function in AIS patients using cardiovascular MRI (CMR) may help to detect HF. We report the rate of systolic and diastolic dysfunction in a cohort of patients with AIS using CMR and compare cine real-time (CRT) sequences with the reference of segmented cine steady-state free precession sequences. Methods and results Patients with AIS without known atrial fibrillation were prospectively enrolled in the HEart and BRain Interfaces in Acute Ischemic Stroke (HEBRAS) study (NCT 02142413) and underwent CMR at 3 Tesla within 7 days after AIS. Validity of CRT sequences was determined in 50 patients. A total of 229 patients were included in the analysis (mean age 66 years; 35% women; HF 2%). Evaluation of cardiac function was successful in 172 (75%) patients. Median time from stroke onset to CMR was 82 h (interquartile range 56-111) and 54 h (interquartile range 31-78) from cerebral MRI to CMR. Systolic dysfunction was observed in 43 (25%) and diastolic dysfunction in 102 (59%) patients. Diagnostic yield was similar using CRT or segmented cine imaging (no significant difference in left ventricular ejection fraction, myocardial mass, time to peak filling rate, and peak filling rate ratio E/A). Intraobserver and interobserver agreement was high (κ = 0.78-1.0 for all modalities). Conclusions Cardiovascular MRI at 3 Tesla is an appropriate method for the evaluation of cardiac function in a selected cohort of patients with AIS. Systolic and diastolic dysfunction is frequent in these patients. CRT imaging allows reliable assessment of systolic and diastolic function.

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Factors influencing left atrial volume in a population with preserved ejection fraction: Left ventricular diastolic dysfunction or clinical factors?

Abstract: LA enlargement was independently associated with moderate and severe DD, but not with mild DD. Furthermore, obesity and lower hemoglobin were associated with LAV independently of DD.

Cited by 10 publications

References 42 publications

The optimal cut-off of blood pressure related to left ventricular diastolic dysfunction and remodeling in Asian diabetic patients

The optimal cut-off of blood pressure related to left ventricular diastolic dysfunction and remodeling in Asian diabetic patients

Blunting of estrogen modulation of cardiac cellular chymase/RAS activity and function in SHR

Evaluation of left ventricular function in patients with acute ischaemic stroke using cine cardiovascular magnetic resonance imaging

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