Factors inducing relapse in inflammatory bowel disease.

Abstract

801Razoxane in treatment of acute myeloid leukaemia Razoxane (ICRF 159; 1, propane, Cl ,H16N404) has been used for treating acute leukaemia.' It is thought to act as an inhibitor of RNA, or more likely of DNA, and to interfere with cell division at the G2/M phase of the cell cycle.2 After recent claims of success with razoxane and cystosine in treating acute myeloid leukaemia and the relative absence of side effects, we decided to treat consecutive and unselected patients with acute myeloid leukaemia with this combination. Patients, methods, and resultsSeventeen consecutive cases seen by us between October 1977 and February 1978 were included in the study. There were 10 adults with acute myeloblastic leukaemia (age range 35-78), of whom two had been previously treated and were resistant to other cytotoxic drugs; five cases of acute myelomonocytic leukaemia (age range 14-82); and two cases of chronic granulocytic leukaemia (CML) in blast transformation (age range 29-39).Razoxane was given by mouth in a dose of 125 mg three times daily, and cytarabine intravenously in a daily dose of 1 mg/kg body weight. Both drugs were given for three consecutive days and the course repeated at ten-day intervals. When no satisfactory response was achieved the dosage was increased to 125 mg razoxane four times a day and cytarabine to 2 mg/kg body weight/day.

Factors Preceding Relapse of Ulcerative Colitis

“…Some support for these observations comes from recent suggestions that both Campylobacter jejunum and Clostridium dif ficile may be associated with relapse of UC [3,4], The main observation of a study by Mee and Jewell [5] was that relapse was often preceded by upper respiratory tract infection (URTI) without antibiotic use, a finding con firmed by our survey, with 24 relapses being preceded by an URTI. However, when ex amined the other way round, the vast major ity of URTI were not followed by relapse.…”

Analgesic ingestion and other factors preceding relapse in ulcerative colitis.

“…Over a 14 month period, 69 adults with ulcerative proctocolitis established by conventional clinical, radiological, and histological criteria (Table 1) were asked, by means of a standardised questionnaire, about the events occurring in the four weeks (1) before clinic attendance of the 62 patients presenting in remission, or (2) preceding the onset of relapse in the 21 patients attending with active disease.2 Remission was defined by the passage of a formed stool up to three times daily without rectal bleeding, abdominal pain, or systemic ill-health; in the 14 patients in remission in whom sigmoidoscopy was performed, the rectal mucosa was normal or oedematous only.7 Relapse was indicated by more frequent passage of loose stools with rectal bleeding and often mucopus, abdominal pain, and malaise; in every case it was confirmed by the presence of mucosal inflammation with contact or spontaneous bleeding at sigmoidoscopy.7 Rampton, McNeil, 2 3…”

Seasonal clustering in inflammatory bowel disease: a single centre experience

“…In this regard, the investigation of seasonal cluster in CUC is very timely and necessary [2][3][4][5][6][7][8]. Monthly clustering patterns in flares of inflammatory bowel disease (IBD) have been previously reported [9][10][11][12][13][14][15]. However, very few studies have investigated seasonal variability, and then only in Western populations [1][2][3][4][5][6][7][8].…”