Factors Associated with Seronegative Chronic Hepatitis C Virus Infection in HIV Infection

Abstract

Detectable HCV RNA in the context of a negative HCV enzyme immunoassay 2.0 result in HIV-infected patients is low, but higher than the reported prevalence in HIV-uninfected patients. Our findings suggest that HCV RNA testing should be performed in anti-HCV-negative, HIV-infected patients, especially those with a history of IDU and either a CD4 cell count <200 cells/ micro L or an abnormal ALT level.

The Efficiency of Hepatitis C Virus Core Antigen Test in the Diagnosis of Hepatitis C Infection

“…The reason for these cases are severe immunosuppression, hemodialysis, AIDS and agammaglobulinemia (17,18,19). In this study, HCV RNA (5.2x10 6 IU/mL), and HCV core antigen (1.58x10 4 fmol/L) were positive in serum of a chronic liver disease patient with a negative anti-HCV assay (0.12).…”

Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV‐1 infection 2015: optimizing health in preparation for adult life

“…This should include HCV antibody and HCV RNA PCR when available, as rates of 3–13% of HCV‐seronegative infection have been reported in HIV‐infected adult and paediatric cohorts 133, 134, 135. HCV antigen might be used by some laboratories in screening algorithms.…”

HIV Co-Infections with Hepatitis B and C

“…Those with antibody to HCV should have quantitative HCV RNA testing to confirm the presence of viremia and serve as a baseline prior to therapy initiation [78]. Some patients with more advanced immunosuppression (e.g.CD4<100cells/µl ) may have a false negative serology test (about 5%) and should be screened further with HCV RNA testing especially if they have risk factors of HCV acquisition such as injection drug use [105][106][107].…”