HIV Co-Infections with Hepatitis B and C

Singhatiraj, Ekachai; Suri, Joshan; Goulston, Claudia

doi:10.4172/2155-6113.s3-001

Cited by 5 publications

(1 citation statement)

References 134 publications

(123 reference statements)

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“…The introduction of highly active antiretroviral therapy (HAART) has significantly improved the survival in patients infected with HIV (9). However, liver disease caused by HBV and HCV co-infections, chronic alcohol abuse, hepatic tuberculosis or hepatotoxicity due to antiretroviral drugs have now emerged as a major cause of mortality in these patients (10,11). In co-infected patients, these viruses have significant interaction, amplifying the pathogenicity of individual agent, leading to higher morbidity and mortality (12,13).…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B and C Sero-prevalence in Patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome at a Tertiary Care Hospital in Izmir

Atalay¹,

Kiş²,

Sönmez³

et al. 2018

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Objectives: Infections caused by human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) represent a significant health problem. Co-infection with these viral agents is not uncommon as a result of the similar transmission routes. Our study was planned to investigate the prevalence of HBV and HCV infections in HIV/Acquired Immune Deficiency syndrome (AIDS) patients followed up at our institution. Materials and Methods: In this study conducted in the Department of Infectious Diseases and Clinical Microbiology at Izmir Tepecik Training and Research Hospital, medical records of patients followed at the HIV/AIDS outpatient clinic between August 2002 and December 2014 were evaluated. Demographic data, main route of HIV transmission, hepatitis B surface antigen (HBsAg), anti-hepatitis B core (HBc) immunoglobulin G (IgG), anti-HBs and anti-HCV results were evaluated. Results: A total of 157 treatment-naïve patients who were followed up at our HIV/AIDS outpatient clinic were included in this study. Four patients (2.6%), had HBsAg positivity. Anti-HBc IgG and anti-HBs positivity were detected in 34% and 28.4% of the patients, respectively. No patients had anti-HCV positivity. Conclusion: The prevalence of HBsAg in HIV-positive individuals was found to be similar to that in other population-based studies in our country. Absence of anti-HCV positivity suggests that hepatitis C infection is not a major health problem in this population.

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Section: Introductionmentioning

confidence: 99%

Hepatitis B and C Sero-prevalence in Patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome at a Tertiary Care Hospital in Izmir

Atalay¹,

Kiş²,

Sönmez³

et al. 2018

vhd

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Viral co-infections in high-risk communities of Pakistan

et al. 2015

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Association between IL28B Polymorphisms and Outcomes of Hepatitis B Virus Infection: A meta-analysis

et al. 2020

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Background: Interleukin (IL) 28B polymorphisms encoding pro-inflammatory and anti-inflammatory cytokines trigger diverse clinical outcome of hepatitis virus infection. However, there is controversy concerning the association of IL28B polymorphisms with the outcome of hepatitis B virus (HBV) infection, with several studies obtaining inconsistent results. We performed a meta-analysis to evaluate the role of 3 single nucleotide polymorphisms (SNPs) rs12979860, rs12980275 and rs8099917 in the progression of HBV infection, overall and by ethnicity. Methods: Searched PubMed, Embase and Wiley Online Library electronic databases using 'interleukin 28B', 'IL 28B', 'IL 28B polymorphism', 'hepatitis B virus', 'HBV', and performed meta-analysis for rs12979860, rs12980275 and rs8099917 in Asian and Caucasian populations under the dominant recessive and allele model. Results: Eighteen studies were found in total and used for this meta-analysis, including 5587 cases and 4295 controls. The IL28B polymorphism rs12979860 had no association with HBV persistence (CC vs CT + TT: OR = 0.86, 95% CI = 0.76-1.00; TT vs CT + CC: OR = 1.14, 95% CI = 0.76-1.70; T vs C: OR = 1.03, 95% CI = 0.94-1.13). Similarly, neither rs12980275 nor rs8099917 had associations with HBV persistence (rs12980275 in AA vs AG + AA: OR = 1.15, 95% CI = 0.96-1.38; rs8099917 in TT vs GT + GG: OR = 1.15, 95% CI = 0.96-1.39). There was also no significant association of IL28B polymorphisms with persistent HBV infection in Asians or Chinese. There was no evidence of an association of rs12979860 with the HBV-related hepatocellular carcinoma susceptibility (T vs C: OR = 1.53, 95% CI = 0.96-2.43). Conclusion: IL28B polymorphisms had no association with the outcome of HBV infection overall, nor in the Asians and the Chinese. These 3 SNPs might not be relevant to the development of HBV infection.

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HIV Co-Infections with Hepatitis B and C

Cited by 5 publications

References 134 publications

Hepatitis B and C Sero-prevalence in Patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome at a Tertiary Care Hospital in Izmir

Hepatitis B and C Sero-prevalence in Patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome at a Tertiary Care Hospital in Izmir

Viral co-infections in high-risk communities of Pakistan

Association between IL28B Polymorphisms and Outcomes of Hepatitis B Virus Infection: A meta-analysis

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