Factors associated with neuropsychological 
performance in HIV-seropositive subjects without AIDS

Pereda, A.; Ayuso-Mateos, José Luís; Barrio, Andrés Gómez del; Echevarría, S.; Fariñas, M C; Palomo, D. García; Macías, J. González; Vázquez‐Barquero, José Luís

doi:10.1017/s0033291799001348

Cited by 63 publications

(56 citation statements)

References 48 publications

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“…They further reported that there is no difference between the neuropsychological performance of seropositive male and female subjects. Pereda et al (2000), Rabkin et al (2000) found same result. …”

Section: Agesupporting

confidence: 73%

“…Both age and HIV status have been established as independent risk factors for the development of cognitive impairment, it is both reasonable and important to question whether the interaction of these two factors may constitute increased risk of impairment in HIV-infected individuals. While several studies have explored the impact of age on cognitive function in HIV infected subjects (Janssen et al, 1992;McArthur et al, 1993;Kim et al, 2001;Pereda et al, 2000) few have examined the interaction of age and disease status (Van Gorp et al, 1994;Hardy et al, 1999). Kissel et al, (2005) reported that Age and disease status had independent effects on cognitive function, but there were no significant interactions either on a summary measure of performance or on individual test scores.…”

Section: Agementioning

confidence: 99%

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Factors Associated with Neuropsychological Impairment in HIV Infection

Rai¹,

Dutta²,

Kumar³

2011

HIV-infection - Impact, Awareness and Social Implications of Living With HIV/AIDS

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Section: Agesupporting

confidence: 73%

Section: Agementioning

confidence: 99%

Factors Associated with Neuropsychological Impairment in HIV Infection

Rai¹,

Dutta²,

Kumar³

2011

HIV-infection - Impact, Awareness and Social Implications of Living With HIV/AIDS

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“…One criticism is the manner in which the reserve construct has been defined. In many HIV studies (Stern et al, 1996;Pereda et al, 2000), either VIQ, educational attainment, or occupational attainment is the definition of convenience. In such studies, the definition is a proxy for an assemblage of unmeasured factors which may or may not be relevant to the structural or functional capacity of the brain.…”

Section: Discussionmentioning

confidence: 99%

“…In this version, high levels of reserve are hypothesized to antagonize the adverse effects of neuropsychiatric disease (Pereda et al, 2000;Staff et al, 2004;Stern, 2002). In contrast, low levels amplify adverse effects.…”

Section: Introductionmentioning

confidence: 99%

The effects of HIV on P300 are moderated by familial risk for substance dependence: Implications for a theory of brain reserve

Bauer

2008

Drug and Alcohol Dependence

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Background-The goal of the study was to test the validity of additive versus synergistic versus underadditive versions of brain reserve theory within the context of HIV/AIDS. In addition, it tested the convergent validity of 2 operational definitions of premorbid reserve: verbal IQ (VIQ) and a family history (FH) of substance abuse or dependence.Methods-Seventy HIV-1 seronegative and 115 HIV-1 seropositive male and female volunteers were assigned to 4 subgroups defined by the crossing of a VIQ score < versus ≥ 90 with the presence versus absence of a paternal history of alcohol, cocaine, or opiate abuse or dependence. The principal dependent measure was the P300 event related brain potential elicited during the Stroop color-word interference task.

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“…Esto tiene sentido ya que la reserva cognitiva tiene una alta variabilidad entre las personas que, precisamente, puede normalizarse siempre y cuando conozcamos y registremos, a través de instrumentos adecuados, qué factores son los que intervienen en su unidad como constructo a estudiar. Hasta la fecha se ha recurrido a diferentes estimaciones para su medida, referidas bien sólo a la inteligencia premórbida (36,37), a la combinación de ésta, con los años de educación y el nivel ocupacional (38)(39)(40), o a la inteligencia premórbida y los años de educación (40).…”

Section: Originales Y Revisionesunclassified

Análisis del desempeño cognitivo de los enfermos con Parkinson: importancia del nivel educativo

Hernández¹,

Cruz²

2013

Rev. Asoc. Esp. Neuropsiq.

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Recibido: 18/07/2012; aceptado con modificaciones: 07/01/2013 RESUMEN: Introducción. Las experiencias vitales, entre ellas la educación, capacitan a las personas para tolerar los efectos de una patología. En la enfermedad de Parkinson (EP) esta reserva cognitiva podría estar beneficiando el rendimiento cognitivo de los pacientes y actuando con un atenuador de los sín-tomas derivados de una posible demencia asociada. El objetivo de este trabajo es el de estudiar el efecto del nivel de educación sobre el rendimiento cognitivo en una muestra de pacientes con EP, e investigar si existe relación entre el nivel de educación adquirido, el deterioro cognitivo y el inicio de la enfermedad. Pacientes y método: La muestra estuvo compuesta por 30 pacientes con diagnóstico de Parkinson sin demencia, que fueron distribuidos en tres grupos dependiendo de su nivel de escolaridad (básica, media y superior), y a los que se les aplicó el MiniMental Parkinson (MMP) como medida de rendimiento cognitivo, y la escala autoaplicada para la evaluación de la depresión con el Inventario de Depresión de Beck (BDI), con el fin de descartar trastornos depresivos. Resultados: Se obtuvieron diferencias significativas entre el nivel de educación básico y los niveles medio y superior (p= 0,016, p= 0,003, respectivamente). No se encontraron efectos significativos con la edad de inicio de la EP entre los tres grupos analizados. El análisis de las subpruebas del MMP no arrojó diferencias significativas; sin embargo, se obtuvo una correlación moderada entre la subprueba de memoria y los años de escolaridad (r= 0,407, p< 0,005). Conclusiones: El nivel de educación puede estar afectando al rendimiento cognitivo en la vejez y funcionar como un atenuador de los síntomas, mejorando la habilidad adquirida del cerebro a través de la experiencia (e.g., educación), para tolerar los efectos de una patología. PALABRAS CLAVE: Deterioro cognitivo, Enfermedad de Parkinson, Nivel de educación, Reserva cognitiva.ABSTRACT: Introduction: Vital experiences, among them education, enable people to tolerate the effects of pathology. In Parkinson disease (PD) this cognitive reserve could benefit the patient's cognitive performance and could act as an attenuator of derived symptoms from a possible associated dementia. The purpose of this study is to determine the effect of educational level on the cognitive performance in a sample of patients with PD and to investigate if there is any type of relation between acquired educational level, cognitive deterioration and the beginning of the disease. Patients and method: the sample consisted of 30 patients diagnosed with Parkinson disease without dementia, that were distributed in three groups according to their educational level (basic, middle and high), they were assessed with the Mini Mental Parkinson (MMP) test as a measurement method for the cognitive performance, and the self applied Beck's Depression Inventory (BDI) scale to discard depressive disorders. Results: We obtained significant differences between the basic, the mi...

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Factors associated with neuropsychological performance in HIV-seropositive subjects without AIDS

Cited by 63 publications

References 48 publications

Factors Associated with Neuropsychological Impairment in HIV Infection

Factors Associated with Neuropsychological Impairment in HIV Infection

The effects of HIV on P300 are moderated by familial risk for substance dependence: Implications for a theory of brain reserve

Análisis del desempeño cognitivo de los enfermos con Parkinson: importancia del nivel educativo

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