Factors associated with mercury levels in human placenta and the relationship to neonatal anthropometry in Jamaica and Trinidad &amp; Tobago

Ricketts, Phylicia; Fletcher, Horace; Voutchkov, Mitko

doi:10.1016/j.reprotox.2017.04.008

Cited by 3 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The average fish consumption per capita is 27.1 kg/year in Jamaica [90] that is about 1.5 times higher than the world's per capita fish food supply [91]. A study in Jamaica has reported that maternal fish intake was the most significant factor associated with Hg levels in the placenta [92]. Therefore, continuous exposure to Hg is very likely in the Jamaican community via fish consumption.…”

Section: Discussionmentioning

confidence: 99%

Associations of Metabolic Genes (GSTT1, GSTP1, GSTM1) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder

Rahbar

Samms‐Vaughan

Saroukhani

et al. 2021

IJERPH

View full text Add to dashboard Cite

We investigated interactive roles of three metabolic glutathione S-transferase (GST) genes (GSTP1, GSTT1, and GSTM1) and autism spectrum disorder (ASD) status in relation to blood Hg concentrations (BHC) of Jamaican children. We used data from 266 children (2-8 years) with ASD and their 1:1 age- and sex-matched typically developing (TD) controls. After adjusting General Linear Models for child’s age, socioeconomic status, consumption of leafy vegetables, fried plantain, canned fish, and the interaction between GSTP1 and GSTT1, we found significant interactions between GSTP1 and ASD status in relation to BHC either in a co-dominant or dominant genetic model for GSTP1(P < 0.001, P = 0.007, respectively). In the co-dominant model for the Ile105Val GSTP1 polymorphism, geometric mean (GM) BHC in ASD cases with genotype Ile/Ile were significantly higher than in cases with the Ile/Val genotype (0.73 vs. 0.48 µg/L, P = 0.01). In contrast, in TD controls with the Ile/Val genotype GM BHC were significantly higher than in those with the Ile/Ile genotype (0.72 vs. 0.49 µg/L, P = 0.03) or the Val/Val genotype (0.72 vs. 0.51 µg/L, P = 0.04). Although our findings are consistent with the role of GSTP1 in detoxification of Hg, replication in other populations is warranted.

show abstract

Section: Discussionmentioning

confidence: 99%

Associations of Metabolic Genes (GSTT1, GSTP1, GSTM1) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder

Rahbar

Samms‐Vaughan

Saroukhani

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

Placental levels of essential and non-essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models

Álvarez-Silvares

Fernández-Cruz

Bermúdez-González

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Toxicological Effects of Mercuric Chloride Exposure on Scenedesmus quadricauda

Nan

et al. 2022

Water

View full text Add to dashboard Cite

Mercuric chloride (HgCl2) is a common heavy-metal pollutant widely used in commercial products and industry, but its excessive use and uncontrolled discharge have caused great harm to aquatic environments and human health. To research the mechanisms of HgCl2 toxicity in aquatic organisms, this study cultured the green alga Scenedesmus quadricauda in a gradient of HgCl2 concentrations (0, 0.1, 0.3, 0.5, 0.7, and 0.9 mg/L) for 9 days. The results showed that: (1) when the concentrations of HgCl2 were high (≥0.7 mg/L), the toxic effects completely inhibited the growth of algal cells, the culture liquid changed from green to light yellow, and cells aggregated and sank to the bottom. Submicroscopic structural imaging showed that at 0.9 mg/L HgCl2, the algal cells were seriously damaged and obvious plasma–wall separation occurred. Furthermore, the arrangement of photosynthetic lamellae became disordered and the nuclei and protein nuclei faded or even disappeared. (2) When the concentrations of HgCl2 were low and medium (≤0.5 mg/L), the activity of superoxide dismutase (SOD) in algal cells increased in the first five days, but the degree of increase was smaller than in the control group. However, under high HgCl2 concentrations (≥0.7 mg/L), the activity of SOD began to decrease sharply on the seventh day. The activity of peroxidase (POD) decreased more obviously than that of SOD. (3) Under medium and high HgCl2 concentrations (≥0.5 mg/L), the content of malondialdehyde (MDA) in algal cells increased over time, and had not decreased again by the last day of measurement. In contrast, the contents of total protein (TP) and soluble sugar (SS) both exhibited decreasing trends under high HgCl2 concentrations. (4) When the HgCl2 concentrations were ≥0.7 mg/L, the content of photosynthetic pigments in algal cells decreased, and the light quantum yield of PS Ⅱ decreased. At the same time, as culture time progressed, the photosynthetic electron transfer and energy-conversion efficiency were seriously damaged and photosynthesis never returned to normal levels. This research provides a reference for understanding the mechanism by which HgCl2 pollution affects aquatic ecosystems and may help with pollution management in the future.

show abstract

Factors associated with mercury levels in human placenta and the relationship to neonatal anthropometry in Jamaica and Trinidad & Tobago

Cited by 3 publications

References 15 publications

Associations of Metabolic Genes (GSTT1, GSTP1, GSTM1) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder

Associations of Metabolic Genes (GSTT1, GSTP1, GSTM1) and Blood Mercury Concentrations Differ in Jamaican Children with and without Autism Spectrum Disorder

Placental levels of essential and non-essential trace element in relation to neonatal weight in Northwestern Spain: application of generalized additive models

Toxicological Effects of Mercuric Chloride Exposure on Scenedesmus quadricauda

Contact Info

Product

Resources

About