Factors associated with low medication adherence in patients with Type 2 diabetes mellitus attending a tertiary hospital in Bangladesh

Islam, Sheikh Mohammed Shariful; Islam, Mohammad Tauhidul; Uddin, Riaz; Tansi, Tania; Talukder, Shamim Hayder; Sarker, Farhana; Mamun, Khondaker A.; Adibi, Sasan; Rawal, Lal

doi:10.1002/lim2.47

Cited by 7 publications

(9 citation statements)

References 54 publications

(50 reference statements)

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“…Patients with T2D may have hypertension for years prior to the onset of overt diabetes. Furthermore, people with diabetes have shown low medication adherence in Bangladesh, which exposes them to increased risks of diabetes complications [ 40 , 41 , 42 ]. Still, if BP rises further, these patients are subsequently likely to develop CKD and diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes in Bangladesh

Islam

Salehin

Zaman

et al. 2021

IJERPH

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Diabetes and chronic kidney disease (CKD) are a major public health burden in low- and middle-income countries. This study aimed to explore factors associated with CKD in patients with type 2 diabetes (T2D) in Bangladesh. A cross-sectional study was conducted among 315 adults with T2D presenting at the outpatient department of Bangladesh Institute of Health Sciences (BIHS) hospital between July 2013 to December 2013. CKD was diagnosed based on the estimated glomerular filtration rate using the ‘Modification of Diet in Renal Disease’ equations and the presence of albuminuria estimated by the albumin-to-creatinine ratio. Multivariate logistic regression analysis was used to determine the factors associated with CKD. The overall prevalence of CKD among patients with T2D was 21.3%. In the unadjusted model, factors associated with CKD included age 40–49 years (OR: 5.7, 95% CI: 1.3–25.4), age 50–59 years (7.0, 1.6–39), age ≥60 years (7.6, 1.7–34), being female (2.2, 1.2–3.8), being hypertensive (1.9, 1.1–3.5), and household income between 10,001 and 20,000 Bangladeshi taka, BDT (2.9, 1.0–8.2) compared with income ≤10,000 BDT. However, after adjustment of other covariates, only the duration of hypertension and household income (10,001–20,000 BDT) remained statistically significant. There is a need to implement policies and programs for early detection and management of hypertension and CKD in T2D patients in Bangladesh.

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Section: Discussionmentioning

confidence: 99%

Factors Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes in Bangladesh

Islam

Salehin

Zaman

et al. 2021

IJERPH

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“… 9 In another study in Botswana, the prevalence of low medication adherence of anti-diabetic medications was 41.8% among patients with T2DM. 10 In 2021, Islam et al 11 reported a prevalence of low medication adherence of 48.2% among patients with T2DM in Bangladesh. Low medication adherence is indeed a devastating problem in patients with T2DM and studies have shown that the problem usually increases with the duration after treatment initiation.…”

Section: Introductionmentioning

confidence: 99%

Low medication adherence and its associated factors among patients with type 2 diabetes mellitus attending Amana Hospital in Dar es Salaam, Tanzania: a cross-sectional study

Doya,

Yahaya,

Ngaiza

et al. 2023

International Health

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Background Low medication adherence among patients with type 2 diabetes mellitus (T2DM) is associated with significant morbidity and mortality globally. We investigated the prevalence of low medication adherence and its associated factors among patients with T2DM. Methods We used the Bengali version of the 8-item Morisky Medication Adherence Scale (MMAS-8) in measuring medication adherence among patients with T2DM who were attending the diabetes clinic at Amana Regional Referral Hospital in Dar es Salaam, Tanzania, from December 2021 to May 2022. Binary logistic regression analysis under multivariate analysis was used to determine the predictors of low medication adherence after controlling for confounders. A two-tailed p-value <0.05 was considered significant. Results The prevalence of low medication adherence was 36.7% (91/248) of the subjects included in the study. Lack of formal education (adjusted odds ratio [AOR] 5.3 [95% confidence interval {CI} 1.717 to 16.312], p=0.004), having comorbidities (AOR 2.1 [95% CI 1.134 to 3.949], p=0.019) and drinking alcohol (AOR 3.5 [95% CI 1.603 to 7.650], p=0.031) were the independent predictors of low medication adherence. Conclusion More than one-third of the patients with T2DM in this study had low medication adherence. Our study also showed that a lack of formal education, having comorbidities and drinking alcohol were significantly associated with low medication adherence.

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“…The studies deployed different methods and designs to collect insights on illness perception and medication adherence in adult patients with T2DM. The scoping includes 20 quantitative studies [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. Among the quantitative research, we found one randomized controlled trial (RCT) and two retrospective studies, while the remaining were cross-sectional studies.…”

Section: Findings/resultsmentioning

confidence: 99%

“…Therefore, the context and circumstances of adult patients shape their uptake of medications and treatment. In the study conducted by Islam et al (2021) [ 22 ], the factors influencing T2DM patients’ medication adherence were evaluated, and it was found that 46.3% of 2070 patients had suboptimal levels of medication adherence. The mean age of the participants was 50.2 ± 10.2 years (56.2% females).…”

Section: Discussionmentioning

confidence: 99%

Illness Perception and Medication Adherence among Adult Patients with Type 2 Diabetes Mellitus: A Scoping Review

Alharbi¹,

Alhofaian²,

Alaamri³

2023

Clinics and Practice

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(1) Background: Type 2 diabetes mellitus (T2DM) is a global disease with a compelling impact on developed and developing economies across the globe. The World Health Organization (WHO) (2020) reported a global prevalence of 8.5% in 2014 among adults aged at least 18 years. Consequently, the condition led to a 5% increase in premature mortality from 2000 to 2016. Aim: The scoping review sought to examine illness perception and medication adherence among adult patients with T2DM. (2) Methods: The study was conducted in 2021 and covered articles published in English in the last five years. PubMed, MEDLINE, CINAHL, and ScienceDirect were the primary search engines used to generate the required scholarly records. A total of 20 studies met the inclusion criteria. (3) Results: The 20 studies selected for the scoping review covered different themes on the overall concept of illness perception and medication adherence in adults with Type 2 Diabetes Mellitus. Each study presented unique implications for research and influence on the policymaking relating to the treatment or the management of type 2 diabetes mellitus in adults of different aged groups. (4) Conclusions: The studies reveal both high and low adherence to medications in adults with type 2 diabetes mellitus. The management and treatment of the condition depend on the uptake of oral hypoglycemic agents or insulin as well as the recommended therapies to enhance the clinical outcomes of the patients.

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Factors associated with low medication adherence in patients with Type 2 diabetes mellitus attending a tertiary hospital in Bangladesh

Cited by 7 publications

References 54 publications

Factors Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes in Bangladesh

Factors Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes in Bangladesh

Low medication adherence and its associated factors among patients with type 2 diabetes mellitus attending Amana Hospital in Dar es Salaam, Tanzania: a cross-sectional study

Illness Perception and Medication Adherence among Adult Patients with Type 2 Diabetes Mellitus: A Scoping Review

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