Factors associated with deep circulation in the peripapillary chorioretinal atrophy zone in normal‐tension glaucoma with myopic disc

Kiyota, Naoki; Kunikata, Hiroshi; Takahashi, S.; Shiga, Yukihiro; Omodaka, Kazuko; Nakazawa, Toru

doi:10.1111/aos.13621

Cited by 26 publications

(13 citation statements)

References 44 publications

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“…Studies employing OCT‐A in glaucoma have focused on different regions of the posterior pole, including the peripapillary area, the macular area, or the optic nerve head . For example, Figure presents disc photographs and OCT‐A images in subtypes of angle closure across the disease severity, showing a greatly attenuated peripapillary vascular network in primary angle closure glaucoma (Figure G–I), compared to primary angle closure (Figure D–F), and primary angle closure suspect (Figure A–C).…”

Section: Applications In Optic Nerve Head Diseasesmentioning

confidence: 99%

“…The majority of these studies have shown reduced indices of blood flow glaucoma (Figure G–I), in particular the reduction in the densities of the retinal vessel. However, there remain several limitations.…”

Section: Applications In Optic Nerve Head Diseasesmentioning

confidence: 99%

“…Several investigators have proposed that OCT‐A may have a role in the diagnosis of glaucoma. However, this may be difficult to implement because of the considerations presented earlier (see applications of optic nerve head diseases), inter‐individual variability of optic nerve head microvasculature among healthy eyes, remodelling of the optic nerve head during glaucoma and challenges associated with comparing diagnostic performance studies . Instead, OCT‐A may be a viable clinical tool in glaucoma patients with high myopia, replacing structural OCT – the results of which are often biased by the abnormal anatomical configuration of the optic nerve head in highly myopic individuals.…”

Section: Requirements To Transform Oct‐a To a Clinical Toolmentioning

confidence: 99%

“…Several studies have focused on vessel density in glaucoma eyes with myopia . Shin et al showed that, in glaucoma patients with high myopia, peripapillary vessel density measured by OCT‐A better correlated with visual field mean sensitivity than retinal nerve fibre layer thickness assessment.…”

Section: Requirements To Transform Oct‐a To a Clinical Toolmentioning

confidence: 99%

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Future clinical applicability of optical coherence tomography angiography

Chua

Tan

Ang

et al. 2019

Clinical and Experimental Optometry

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Optical coherence tomography angiography (OCT-A) is an emerging technology that allows for the non-invasive imaging of the ocular microvasculature. Despite the wealth of observations and numerous research studies illustrating the potential clinical uses of OCT-A, this technique is currently rarely used in routine clinical settings. In this review, technical and clinical aspects of OCT-A imaging are discussed, and the future clinical potential of OCT-A is considered. An understanding of the basic principles and limitations of OCT-A technology will better inform clinicians of its future potential in the diagnosis and management of ocular diseases.

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Section: Applications In Optic Nerve Head Diseasesmentioning

confidence: 99%

Section: Applications In Optic Nerve Head Diseasesmentioning

confidence: 99%

Section: Requirements To Transform Oct‐a To a Clinical Toolmentioning

confidence: 99%

Section: Requirements To Transform Oct‐a To a Clinical Toolmentioning

confidence: 99%

See 2 more Smart Citations

Future clinical applicability of optical coherence tomography angiography

Chua

Tan

Ang

et al. 2019

Clinical and Experimental Optometry

View full text Add to dashboard Cite

show abstract

“…; Kiyota et al. ). To date, OCT‐A imaging has been shown only in six genetically confirmed cases with visual loss due to LHON (De Rojas et al.…”

Section: Introductionmentioning

confidence: 96%

Peripapillary microcirculation in Leber hereditary optic neuropathy

Kousal

Kolářová

Meliska

et al. 2018

Acta Ophthalmologica

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Purpose In this prospective observational comparative case series, we aimed to study the peripapillary capillary network with spectral‐domain optical coherence tomography angiography (OCT‐A) in Leber hereditary optic neuropathy (LHON). Methods Twelve eyes of six individuals, of these three males (five eyes) after clinical onset of visual impairment were imaged by OCT‐A with scans centred on optic discs. Control group consisted of 6 eyes with no visual impairment. Results The three affected individuals lost vision 6 years (at age 22 years), 2 years and 3 months (at age 26 years) and 1 year and 2 months (at age 30 years) prior to OCT‐A examination. All five affected eyes had alterations in density of the radial peripapillary microvascular network at the level of retinal nerve fibre layer, including an eye of a patient treated with idebenone that underwent almost full recovery (best corrected visual acuity 0.87). Interestingly, the other eye showed normal ocular findings 14 months after onset. Results of OCT‐A examination in this eye were unfortunately inconclusive due to a delineation error. At the level of the ganglion cell layer differences could be also noted, but only in two severely affected individuals. There were no differences between unaffected mutation carriers and control eyes. Conclusion Optical coherence tomography angiography scans confirmed that the peripapillary microvascular network is highly abnormal in eyes manifesting visual impairment due to LHON. These findings support the hypothesis that microangiopathy contributes to the development of vision loss in this mitochondrial disorder.

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Factors associated with intrachoroidal cavitation and sinkhole formation in eyes with glaucomatous visual-field defects

Yamaguchi,

Kiyota,

Takahashi

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Purpose To investigate factors associated with intrachoroidal cavitation (ICC) and sinkhole formation in eyes with glaucomatous visual-field defects. Methods This retrospective, cross-sectional study enrolled a total of 2808 eyes of 1482 patients who were diagnosed/treated for glaucoma and underwent swept-source optical coherence tomography (OCT). We first determined the prevalence of ICCs and sinkholes and their locations. Next, we selected one eye from each patient and compared the clinical characteristics of eyes with and without ICCs. Finally, in eyes with ICCs, we compared the clinical characteristics of eyes with and without sinkholes. Blood flow (BF), represented by laser speckle flowgraphy–measured tissue-area mean blur rate (MBR), was measured in the temporal optic nerve head (ONH), temporal peripapillary chorioretinal atrophy (PPA) zone, and in the ICC zone. ICC area and angle were analyzed in OCT en-face images. Mean deviation and total deviation in the central area (TD-central) were measured with Humphrey visual-field testing. Results A total of 86 eyes (3.1%) had ICCs and 52 eyes (1.9%) had sinkholes. ICC eyes had a lower spherical equivalent and longer axial length (AL) than non-ICC eyes (P < 0.05). Patients with eyes with sinkholes were more elderly and had worse best-corrected visual acuity, worse TD-central, a larger ICC, and lower tissue-area MBR in the temporal ONH, temporal PPA zone, and ICC zone (P < 0.05). Conclusion In eyes with glaucoma, AL elongation might be linked to ICC formation. Sinkhole formation might be associated with ICC enlargement, impaired ocular BF, and impaired retinal structure and function involving the central area.

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Factors associated with deep circulation in the peripapillary chorioretinal atrophy zone in normal‐tension glaucoma with myopic disc

Cited by 26 publications

References 44 publications

Future clinical applicability of optical coherence tomography angiography

Future clinical applicability of optical coherence tomography angiography

Peripapillary microcirculation in Leber hereditary optic neuropathy

Factors associated with intrachoroidal cavitation and sinkhole formation in eyes with glaucomatous visual-field defects

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