Factors associated with compensatory lung growth after pulmonary lobectomy for lung malignancy: an analysis of lung weight and lung volume changes based on computed tomography findings

Wakamatsu, Ikuma; Matsuguma, Haruhisa; Nakahara, Rie; Chida, Masayuki

doi:10.1007/s00595-019-01863-0

Cited by 10 publications

(5 citation statements)

References 27 publications

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“…This criterion of respiration noticed on all treated animals, while on control group regularity of respiratory rate lasted until 7-10 days' post operation. This phenomenon might be related with adaptability of the lung to compensate of the deprivation of the right middle lung lobe, these results agreed with Wakamatsu et al (17), who explained that dogs were capable of respiratory compensation immediately after pneumonectomy and maintained appropriate oxygenation and remained hemodynamically stable. Dogs undergoing pneumonectomy may have already begun to institute compensatory mechanisms for reduced pulmonary function, explaining the superior function of existing pulmonary parenchyma.…”

Section: Physiological Parameterssupporting

confidence: 90%

Effect of nano-magnesium oxide and harmonic scalpel on lung lobectomy healing in dogs: Clinical and cytokine study

Bader¹,

Eesa²

2021

IJVS

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The aim of the present study was to evaluate the effect of magnesium oxide nanoparticles and the role of the harmonic scalpel in lung tissue healing at the site of a middle lobe resection of the right lung. Twenty-four adult domestic dogs were used. They were randomly divided into two equal groups (control and treated group). The middle lobe of the right lung was excised by harmonic scalpel with titanium clamps to control bleeding and infiltration of air bubbles. The clinical and physiological condition of the animals was studied in the two-week period after surgery and molecular evaluation at time of zero, first, third, fifth, seventh, fourteenth, twenty-first, twenty-eighth, and thirty-fifth days after operation by interleukin-6 and tumor necrosis factor-α. The result of clinical observation showed that dogs in both groups took 2-4 days after the operation to gain full activity. The heart and respiratory rate were within the normal level before and during the operation, and when the animal began to recover, the heartbeat and respiratory rate began to rise with irregularity and the irregularity continued for 3-5 hours after the completion of the operation and then returned to its normal level within 24 hours after the operation. These changes in heart rate and respiratory system were observed in all treated animals, while heart rhythm and respiratory rates persisted in the control group until several days after the operation. In the molecular evaluation, the results for interleukin-6 and tumor necrosis factor-α showed a significant difference in the mean values of these two factors between control and treated.

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Section: Physiological Parameterssupporting

confidence: 90%

Effect of nano-magnesium oxide and harmonic scalpel on lung lobectomy healing in dogs: Clinical and cytokine study

Bader¹,

Eesa²

2021

IJVS

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“…The findings of this study may be contextualized within the broader scope of existing research, including several previous studies on lobectomy cases that have demonstrated a correlation between increased compensatory lung growth rate and larger resection volumes ( 4 , 5 , 13 , 16 , 18 ). Ueda et al conducted a comparative investigation of the rate of postoperative lung volume increase between lobectomy and segmentectomy, revealing that lobectomy cases experienced more pronounced expansion of the remaining lung ( 5 ).…”

Section: Discussionmentioning

confidence: 76%

“…3D-CT is useful not only for defining the anatomy of the pulmonary vasculature and bronchi but also for calculating lung volumes. Several studies have reported that the estimated postoperative pulmonary function based on preoperative 3D-CT is well correlated with pulmonary function test values ( 12 , 13 ).…”

Section: Introductionmentioning

confidence: 99%

An analysis of residual lung volume changes after segmentectomy based on three-dimensional computed tomography

Abe,

Osoegawa,

Karashima

et al. 2024

J Thorac Dis

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“…After lung surgery, compensatory lung growth (CLG) can improve lung function beyond expectations ( 22 ). Lung weight measurements are used to evaluate CLG development ( 23 ). An increase in volume without accompanying weight gain indicates hyperinflation, whereas an increase in weight without volume gain suggests congestion ( 24 ), neither of which revealed a significant increase in pulmonary blood flow over time.…”

Section: Discussionmentioning

confidence: 99%

Relationship between pulmonary blood flow and volume following lung resection using dynamic perfusion digital radiography

Hanaoka,

Hayashi,

Shiratori

et al. 2023

J Thorac Dis

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Background Surgical intervention for lung resection can cause ventilation-perfusion mismatches and affect gas exchange; however, minimally invasive assessment of blood flow is difficult. This study aimed to evaluate changes in pulmonary blood flow after radical lung cancer surgery using a minimally invasive dynamic digital chest radiography system. Methods We evaluated 64 patients who underwent radical lobectomies. Postoperative changes in pulmonary blood flow, assessed using dynamic chest radiography-based blood flow ratios (BFRs), were compared with the temporal evolution of both functional lung volumes (FLVs) and estimated lung weight (ELW) derived from computed tomography (CT) volumetry. Results FLVs on the affected side gradually recovered over time from the lowest value observed 3 months after surgery in all procedures. BFRs on the affected side also showed a gradual recovery from the lowest value 1 month after surgery, except for left upper lobectomies (LULs). In LULs, FLVs and ELWs increased proportionally up to 3 months after surgery, with lung volumes continuing to increase thereafter. The recovery of BFRs differed depending on the resected lobe. Conclusions A relationship between pulmonary blood flow and FLV was observed in the postoperative period. Despite varying compensatory responses depending on the surgical procedure, FLV recovery coincided with increased pulmonary blood flow.

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Factors associated with compensatory lung growth after pulmonary lobectomy for lung malignancy: an analysis of lung weight and lung volume changes based on computed tomography findings

Cited by 10 publications

References 27 publications

Effect of nano-magnesium oxide and harmonic scalpel on lung lobectomy healing in dogs: Clinical and cytokine study

Effect of nano-magnesium oxide and harmonic scalpel on lung lobectomy healing in dogs: Clinical and cytokine study

An analysis of residual lung volume changes after segmentectomy based on three-dimensional computed tomography

Relationship between pulmonary blood flow and volume following lung resection using dynamic perfusion digital radiography

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