Factors associated with colonization and infection by Carbapenem Resistant Enterobacteriaceae

Alves, Adelaide; Sucena, Inês; Ribeiro, Carla; Silva, Eloísa; Shiang, Teresa; Vanzeller, Manuela

doi:10.1183/13993003.congress-2018.pa4702

Cited by 2 publications

(3 citation statements)

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“…The bacterium can reside in the gastrointestinal tract as a physiological component of the intestinal flora, on the skin, and in the oral cavity. Unfortunately, in immunocompromised patients, it can cause severe infections, including urinary tract infections, respiratory infections, soft tissue infections, peritonitis and sepsis [ 3 , 4 , 5 , 6 ]. The envelope, lipopolysaccharides (LPS) and cell wall protein receptors are responsible for the pathogenicity of Klebsiella pneumoniae .…”

Section: Introductionmentioning

confidence: 99%

Carbapenem-Resistant Klebsiella pneumoniae Infections in ICU COVID-19 Patients—A Scoping Review

Mędrzycka‐Dąbrowska

Lange²,

Zorena

et al. 2021

JCM

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Introduction: The spread of multidrug-resistant pathogens is a serious problem and challenge for the whole medical community. Carbapenem-resistant Klebsiella Pneumoniae (CRKP) infections in immunocompromised patients have a severe course and may be fatal. Increasingly, these bacteria are exhibiting resistance to carbapenem antibiotics, which have been used as so-called drugs of last resort. The emergence of the new coronavirus and the pandemic that it has caused require changes to protect against the spread of the new SARS-CoV-2. These changes paradoxically may contribute to the spread of other infections. Methods: PubMed, Cochrane Library databases were searched using relevant keywords. A literature review of carbapenem-resistant Klebsiella Pneumoniae infection in patients hospitalized for COVID-19 was conducted according to PRISMA recommendations. A written review protocol was not prepared. Results: 1016 studies in scientific databases were searched. After rejecting duplicate studies, 964 results were obtained. Inclusion and exclusion criteria were then applied, and studies were qualitatively analyzed. Finally, 11 studies were included in the review. The results of infected patients were from six countries. The prevalence of CRKP in Covid-19 patients ranged from 0.35–53%. The majority of CRKP infected patients were male (85%), with a mean age of 61 years. Among isolates, the predominant genes were KPC, OXY-48, CTX-M, TEM, NDM and SHV. Conclusion: The results presented in our review indicate the necessity of paying attention to carbapenem-resistant Klebsiella Pneumoniae infections in patients with COVID-19. In order to prevent the increase of bacterial resistance, rational antibiotic therapy should be used, as well as continuous control and surveillance of hospital infections caused by multidrug-resistant organisms.

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Section: Introductionmentioning

confidence: 99%

Carbapenem-Resistant Klebsiella pneumoniae Infections in ICU COVID-19 Patients—A Scoping Review

Mędrzycka‐Dąbrowska

Lange²,

Zorena

et al. 2021

JCM

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“…The majority of infections by this opportunistic pathogen are associated with the elderly, the immunocompromised, and neonates, where urinary tract infections, wound and soft tissue infections, and pneumonia are the most commonly reported. Intensive care unit (ICU)-related infections, sepsis, and infections of surgical site are additionally reported [3][4][5][6][7]. K. pneumoniae is generally listed as one of the most frequent causes for hospital-acquired infections (HAIs) [8], with organisations such as the European Union (EU), World Health Organisation (WHO), and the Centres for Disease Control and Prevention (CDC) recognising the bacterium to be a significant threat to global public health [9,10].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic Analysis, Population Structure, and Characterisation of Multidrug-Resistant Klebsiella pneumoniae from the Al-Hofuf Region of Saudi Arabia

et al. 2021

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Multidrug-resistant Klebsiella pneumoniae (MDR-KP) is a major public health problem that is globally associated with disease outbreaks and high mortality rates. As the world seeks solutions to such pathogens, global and regional surveillance is required. The aim of the present study was to examine the antimicrobial susceptibility pattern and clonal relatedness of Klebsiella pneumoniae isolates collected for a period of three years through pulse field gel electrophoresis (PFGE). Isolate IDs, antimicrobial assays, ESBL-production, and minimum inhibitory concentrations (MICs) were examined with the Vitek 2 Compact Automated System. IDs were confirmed by 16S rRNA gene sequencing, with the resulting sequences being deposited in NCBI databases. DNA was extracted and resistance genes were detected by PCR amplification with appropriate primers. Isolates were extensive (31%) and multidrug-resistant (65%). Pulsotype clusters grouped the isolates into 22 band profiles that showed no specific pattern with phenotypes. Of the isolates, 98% were ESBL-KP, 69% were carbapenem-resistant Enterobacteriaceae (CRE) strains, and 72.5% comprised the carriage of two MBLs (SIM and IMP). Integrons (ISAba1, ISAba2, and IS18) were detected in 69% of the MDR-KP. Additionally, OXA-23 was detected in 67% of the isolates. This study therefore demonstrates clonal diversity among clinical K. pneumoniae, confirming that this bacterium has access to an enormous pool of genes that confer high resistance-developing potential.

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Factors associated with colonization and infection by Carbapenem Resistant Enterobacteriaceae

Cited by 2 publications

References 0 publications

Carbapenem-Resistant Klebsiella pneumoniae Infections in ICU COVID-19 Patients—A Scoping Review

Carbapenem-Resistant Klebsiella pneumoniae Infections in ICU COVID-19 Patients—A Scoping Review

Genetic Analysis, Population Structure, and Characterisation of Multidrug-Resistant Klebsiella pneumoniae from the Al-Hofuf Region of Saudi Arabia

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