Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers

Bouillé, Jeanne Goupil de; Vigouroux, Corinne; Plessis, Lorraine; Ghislain, Marc; Teglas, Jean-Paul; Boufassa, Faroudy; Goujard, Cécile; Vignes, Dorothée; Bouchaud, Olivier; Salmon, Dominique; Meyer, Laurence; Abgrall, Sophie; Carlier, Robert; Dray‐Spira, Rosemary; Marchand, Lucie; Petrov–Sanchez, Ventzislava; Rouzioux, Christine; Seng, Rémonie; Thiébaut, Rodolphe; Essabbani, Abdellatif; Feitoza, Tatiana; Keita, Alain-Serge; Tran, Laurent; Fellahi, Soraya; Bastard, Jean‐Philippe; Simon, Anne; Beniken, D.; Girard, Pierre Marie; Ouazene, Zineb; Lefebvre, Bénédicte; Lamarque, J; Ameur, Adam; Pialoux, Gilles; Chas, Julie; Slama, Laurence; Makhoukhi, F Z; Passe-Courtin, P; Gérard, Laurence; Molina, J M; Lascoux-Combe, Caroline; Delgado, José Antonio González-Posada; Parlier, S; Jf, Bergmann; Delcey,; Sellier, Pierre‐Olivier; Rami, Agathe; Parrinello, Michael; Traoré, Lassina; Benmammar, A; Kassim, Mustafa Ali Kassim; Yazdanpanah, Yazdan; Matheron, Sophie; Lariven, Sylvie; Joly,; Rioux, C; Louni, F; Zelie, J; Fantin, Bolognani; Villemant, Agnès; Bazin, C.; Weiss, Lauren A.; Pavie, Juliette; Manea, Maria Adina; Tarnier-Cochin, G H; Pietri, Marie‐Pierre; Viard, Jean‐Paul; Maignan, Aurélie; Dulucq, Marie-Josée; Boué, François; Kansau, Imad; Poirier, Steven; Lambotte, Olivier; Bourdic, Katia; Lelièvre, Jean Daniel; Chesnel, C.; Duvivier, Claudine; Lortholary, O.; Touam, F.; Rey, Diego; Fischer, Peter; and, M L Batard; Zadeh, M. Mohseni; Richard, A; Blaison, G.; Martinot, Marie‐Laure Paillère; Pachard, A; Neau, David; Puil, Séverine Le; Morlat, Philippe; Caldato, S.; Bernard, Louis; Hallouin-Bernard, Marie Charlotte; Bourgault, O; Chirouze, Catherine; Thiebaut-Drobacheff, M C; Proust, Alexis; Gardiennet, Q; Reynes, Jacques; Crisol, Clara Diago; Tramoni, C; May, Thierry; Bouillon, M P; Delestan, M; Andre, M.; Meybeck, Agnès; Marien, Meaghan; Moreau, Julie; Carmantrand, M J; Meddeb, Line; Poizot‐Martin, Isabelle; Guignard, Michel; Betancourt, Cielito; Ivanova, Anna; Raffi, François; Larmetand, L; Hue, H.; Perre, Philippe Van de; Pegeot, A; Cotte, Laurent; Chidiac, C; Ogoudjobi, S; Makhloufi, Djamila; Gibert, Sandra; Cabie, André; Abel, Sylvie; Hochedez, Patrick; Ronin, F; Batalla, Ana; Cerland, C; Pierre-François, Sandrine; Rozé, B.

doi:10.1093/infdis/jiab151

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…The mean BMI in our research was 20.02 ± 3.1 in men and 19.01 ± 2.6 in women. Similar results were demonstrated by the researchers from France -22.1 [16]. However, a significantly higher BMI (40.2) was demonstrated in a study conducted in Australia [17].…”

Section: Heightsupporting

confidence: 87%

Anthropometric Profile of Patients Living With Hiv/Aids in Lviv Region

Orfin

Mazepa

2021

Scientific and practical journal

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The body of PLHIV undergoes profound anthropometric changes in adipose tissue distribution, which develop under the influence of pathogenetic mechanisms caused by HIV and due to impaired side effects of ART. ART leads to the development of lipoatrophy / lipohypertrophy syndrome. This phenomenon is described as a syndrome characterized by the loss and/or accumulation of fat and has three types: lipohypertrophy, lipoatrophy, and mixed lipodystrophy. These changes in body shape are very important to determine because they are associated with negative disease dynamics and high mortality. Therefore, it is extremely important to detect this syndrome early to ensure a better quality of life for this population, as the clinical approach is not easy. Potential approaches to treatment, including lifestyle changes, with adequate eating habits, exercise, and some medical interventions, showed little effect in PLHIV. In this case can be effectively reduced through exercise. Despite the existence of established exercise guidelines, the effective dosage of exercise to reduce HRT requires verification. The aim. Study the anthropometric parameters in PLHIV and establish the relationship between the parameters and the degree of viral load (HV) of HIV, the level of CD4 + T-lymphocytes. Materials and methods: 60 patients aged 18 to 60 years were examined. We used standard methods of measuring the following anthropometric indicators: body weight, height, chest circumference, waist and hips. The waist-to-thigh ratio index was also determined. The calculation of the body mass index was performed according to the standard formula by dividing body weight (in kilograms) by the square of height (in square meters). The indicator 18.5-24.9 is considered normal. The level of CD4 + T-lymphocytes was determined by flow cytofluorometry. The viral load of HIV was determined by real-time PCR. Statistical indicators, median, Pearson's coefficient, Student's t-test, were calculated using Microsoft Excel 2016. Results. The average waist circumference was smaller in both the men of the experimental group (74.5 ± 10.3 cm) and the women of the experimental group (61.9 ± 11.0 cm) than in the control groups of men (90.4 ± 9.4 cm) and women (67.5 ± 7.3 cm (p <0.05)). The average ratio of waist circumference to hip circumference in the group of male PLHIV was 0.94 ± 0.08 cm in the control group of men - 0.97 ± 0.8 cm (p <0.05). In the group of female PLHIV, this indicator reached 0.86 ± 0.1 cm, and in the control group - 0.75 ± 0.3 cm (p <0.05). The mean forearm circumference was lower in the two research groups. However, in men with HIV (18.5 ± 3.1 cm) this figure was lower than in women with HIV (19.9 ± 3.9 cm (p <0.05)). Also, the circumference of the tibia was larger in female PLHIV (26.9 ± 3.9 cm) than in male PLHIV (20.8 ± 3.8 cm (p <0.05)). Conclusions. PLHIV at the stage of AIDS leads to the recomposition of the body. It is manifested by a decrease in BMI, waist circumference, hip, mid-upper arm, and calf, which indicates lipodystrophy. Increase in the index of the waist circumference to hip circumference ratio indicates a probable redistribution of adipose tissue. BMI cannot be used as an accurate method to determine obesity or lipodystrophy. A positive correlation was found between the value of the anthropometric profile and the level of viral load and CD4 + T-lymphocytes. Early administration of ART and dosed exercise is likely to have a positive effect on the body structure of PLHIV in the AIDS stage, although this requires further research.

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Section: Heightsupporting

confidence: 87%

Anthropometric Profile of Patients Living With Hiv/Aids in Lviv Region

Orfin

Mazepa

2021

Scientific and practical journal

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“…Weight gain is multifactorial (Goupil de Bouillé et al, 2021); factors associated with it, and with elevated body weight in HCV co-infected PLHW need to be identified in order to prevent their deleterious consequences. Studies in other populations have found that cannabis use is a potential modifiable protective factor for weight gain and elevated body weight (Alshaarawy & Anthony, 2019;Clark, Jones, Hall, Tabner, & Kmiec, 2018;Meier, Pardini, Beardslee, & Matthews, 2019).…”

Section: Introductionmentioning

confidence: 99%

Cannabis Use as a Protective Factor Against Overweight in HIV-Hepatitis C Virus Co-Infected People (ANRS CO13 HEPAVIH Cohort)

Barré

Sogni

Zaegel-Faucher

et al. 2022

AIDS Education and Prevention

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Overweight is increasingly prevalent in people living with HIV (PLWH), and is a high risk factor for metabolic disorders in this population. PLWH co-infected with hepatitis C virus (HCV) have a higher risk of metabolic disorders than their mono-infected counterparts. The putative relationship between cannabis use and body weight found in the general population has never been documented in HIV-HCV co-infected people. We tested whether cannabis use is associated with body mass index (BMI), overweight, and underweight in HCV co-infected PLWH (N = 992). Mixed-effects linear and logistic regression models were used to study the association between cannabis use and the three outcomes over time. After multivariable adjustment, cannabis use was inversely associated with BMI. Cannabis use was associated with a lower and higher risk of overweight and underweight, respectively. Cannabis use should be assessed and taken into account in the clinical management of the HIV-HCV co-infected population.

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Evidence gaps on weight gain in people living with HIV: a scoping review to define a research agenda

et al. 2023

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Background Combined antiretroviral therapy (cART) dramatically improved survival in people living with HIV (PLWH) but is associated with weight gain (WG), raising concern for a possible obesity epidemic in PLWH. This scoping review aims to identify the gaps in the existing evidence on WG in PLWH and generate a future research agenda. Methods This review was conducted according to the methodology for scoping studies and reported according to the PRISMA Extension for Scoping Review checklist. Articles published in English in the last 10 years indexed in Pubmed, WHO Global Index Medicus, or Embase were searched using specific queries focused on WG in PLWH. Results Following the selection process, 175 included articles were reviewed to search for the available evidence on four specific topics: (I) definition of WG in PLWH, (II) pathogenesis of WG in PLWH, (III) impact of ART on WG, (IV) correlation of WG with clinical outcomes. A summary of the data enabled us to identify gaps and clearly define the following research agenda: (I) develop a data-driven definition of WG in PLWH and define noninvasive assessment methods for body weight and fat composition; (II) further investigate the interaction between HIV/cART and immunity, metabolism, and adipose tissue; (III) establish the specific role of individual drugs on WG; (IV) clarify the independent role of WG, cART, HIV, and metabolic factors on clinical events. Conclusions The proposed research agenda may help define future research and fill the knowledge gaps that have emerged from this review.

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Factors Associated With Being Overweight and Obesity in People Living With Human Immunodeficiency Virus on Antiretroviral Therapy: Socioclinical, Inflammation, and Metabolic Markers

Cited by 3 publications

References 38 publications

Anthropometric Profile of Patients Living With Hiv/Aids in Lviv Region

Anthropometric Profile of Patients Living With Hiv/Aids in Lviv Region

Cannabis Use as a Protective Factor Against Overweight in HIV-Hepatitis C Virus Co-Infected People (ANRS CO13 HEPAVIH Cohort)

Evidence gaps on weight gain in people living with HIV: a scoping review to define a research agenda

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