Factors and Estimation of Risk for Cardiovascular Diseases among Patients in Primary Health Care in Central Serbia

Đokić, Bojan; Đonović, Nela; Tadić, Bojana; Nikolić, Divna

doi:10.21101/cejph.a4009

Cited by 13 publications

(7 citation statements)

References 20 publications

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“…MetS was also common (45.7%) in our HCs with mean age of 51 years. This is in accordance with the findings of Djokic et al who found MetS in 28% of patients aged 40-49 and 43% of patients aged 50-59 at the primary health care institutions in Serbia (21).…”

Section: Discussionsupporting

confidence: 93%

Metabolic syndrome in myotonic dystrophy type 2

Vujnic

Calic

Bucma³

et al. 2017

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 93%

Metabolic syndrome in myotonic dystrophy type 2

Vujnic

Calic

Bucma³

et al. 2017

Journal of the Neurological Sciences

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“…Vitamin D deficiency has been suggested to be associated with a number of conditions including cardiovascular disease [ 22 , 23 ]. The dyslipidemia which is characterized by elevations of LDL, raised TG, and decreases in HDL-C has been well-established as a CVD risk factor [ 24 , 25 ]. Vitamin D may impact cardiovascular health through influencing serum lipids.…”

Section: Discussionmentioning

confidence: 99%

The Associations of Serum Lipids with Vitamin D Status

et al. 2016

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AimsVitamin D deficiency has been associated with some disorders including cardiovascular diseases. Dyslipidemia is a major risk factor for cardiovascular diseases. However, data about the relationships between vitamin D and lipids are inconsistent. The relationship of vitamin D and Atherogenic Index of Plasma (AIP), as an excellent predictor of level of small and dense LDL, has not been reported. The objective of this study was to investigate the effects of vitamin D status on serum lipids in Chinese adults.MethodsThe study was carried out using 1475 participants from the Center for Physical Examination, 306 Hospital of PLA in Beijing, China. Fasting blood samples were collected and serum concentrations of 25(OH)D, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured. AIP was calculated based on the formula: log [TG/HDL-C]. Multiple linear regression analysis was used to estimate the associations between serum 25(OH)D and lipids. The association between the occurrences of dyslipidemias and vitamin D levels was assessed by multiple logistic regression analysis. Confounding factors, age and BMI, were used for the adjustment.ResultsThe median of serum 25(OH)D concentration was 47 (27–92.25) nmol/L in all subjects. The overall percentage of 25(OH)D ≦ 50 nmol/L was 58.5% (males 54.4%, females 63.7%). The serum 25(OH)D levels were inversely associated with TG (β coefficient = -0.24, p < 0.001) and LDL-C (β coefficient = -0.34, p < 0.001) and positively associated with TC (β coefficient = 0.35, p < 0.002) in men. The associations between serum 25(OH)D and LDL-C (β coefficient = -0.25, p = 0.01) and TC (β coefficient = 0.39, p = 0.001) also existed in women. The serum 25(OH)D concentrations were negatively associated with AIP in men (r = -0.111, p < 0.01) but not in women. In addition, vitamin D deficient men had higher AIP values than vitamin D sufficient men. Furthermore, the occurrences of dyslipidemias (reduced HDL-C, elevated TG and elevated AIP) correlated with lower 25(OH)D levels in men, whereas the higher TC and LDL-C associated with higher 25(OH)D levels in women.ConclusionIt seems that the serum 25(OH)D levels are closely associated with the serum lipids and AIP. Vitamin D deficiency may be associated with the increased risk of dyslipidemias, especially in men. The association between vitamin D status and serum lipids may differ by genders.

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“…[ 1 ] Epidemiological studies have confirmed the correlation between total cholesterol (TC) with increased cardiovascular risk. [ 2 ] Apart from pharmaceutical approaches, probiotics therapy also showed a potential effect in TC regulation. Therefore, probiotics triggered a great interest among researchers to treat cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

The effects of probiotics on total cholesterol

Wang

Guo²,

Gao³

et al. 2018

Medicine

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Background:Probiotics supplements provide a new nonpharmacological alternative to reduce cardiovascular risk factors. The impact of probiotics on the reduction of total cholesterol (TC) remains controversial. We conducted a meta-analysis to showcase the most updated and comprehensive evaluation of the studies.Methods:Randomized controlled trials (RCTs) were searched from electronic databases, including PubMed, Embase, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Wanfang database dating from January 2007 to January 2017. The curative effects of probiotics on the reduction of TC were assessed using mean difference (MD), as well as their 95% confidence interval (CI). RevMan software (version 5.3) was used to carry out this meta-analysis.Results:Thirty-two RCTs including 1971 patients met the inclusion criteria. Results of this analysis showed that compared with the control group serum TC was significantly reduced in probiotics group [MD = −13.27, 95% CI (−16.74 to 9.80), P < .05]. In addition, specific strains also significantly reduced serum TC, L acidophilus and B lactis [MD = −8.30, 95% CI (−10.44, −6.15), P < .05]; VSL#3 [MD = −11.04, 95% CI (−19.61, −2.48), P < .05]; L plantarum t ≤ 6 weeks: [MD = −1.56, 95% CI (−6.97, −3.86), P < .05] or t > 6 weeks: [MD = −22.18, 95% CI (−28.73, −15.63), P < .05]. Subgroup analysis indicated that the difference of baseline TC, probiotics forms and intervention duration might have a significant impact on the results. However, strains and doses of probiotics had no significant influence on curative effects.Conclusion:Available evidence indicates that probiotics supplements can significantly reduce serum TC. Furthermore, higher baseline TC, longer intervention time, and probiotics in capsules form might contribute to a better curative effect.

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Factors and Estimation of Risk for Cardiovascular Diseases among Patients in Primary Health Care in Central Serbia

Cited by 13 publications

References 20 publications

Metabolic syndrome in myotonic dystrophy type 2

Metabolic syndrome in myotonic dystrophy type 2

The Associations of Serum Lipids with Vitamin D Status

The effects of probiotics on total cholesterol

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