The Associations of Serum Lipids with Vitamin D Status

Wang, Ying; Si, Shihui; Liu, Junli; Wang, Zongye; Jia, Haiying; Feng, Kai; Sun, Lili; Song, Shujun

doi:10.1371/journal.pone.0165157

Cited by 103 publications

(110 citation statements)

References 52 publications

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“…It has been indicated that dyslipidemia is one of the important CVD risk factors. Previous works have proposed that there is an association between serum vitamin D levels and lipid profile [22,23]. Therefore, the vitamin D-related CVD risk reduction impact can be attributed to the improvement of vitamin D mediated dyslipidemia.…”

Section: Introductionmentioning

confidence: 99%

The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents

et al. 2020

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Background: The association between vitamin D status and inflammatory biomarkers and lipid profile is not well known, especially in adolescents. Therefore, the aim of the current study is to investigate the association of vitamin D status with serum lipids and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, in male adolescents. Methods and materials: A sample of seventy-one high school male students, aged 17 years old, from a high school in Tehran were enrolled in the study. They were divided into four groups including group with serum vitamin D below 25 (ng/mL) (SVD < 25; n = 36), 25 and above (ng/mL) (SVD ≥ 25; n = 35), negative-hsCRP (n = 48), and positive-hsCRP (n = 23). Weight, height, body mass index, dietary intake, serum lipids, and inflammatory biomarkers, including IL-10, IL-6, hsCRP, and TNFR-2, were measured. Results: In the (SVD < 25) group, the serum level of TNFR-2 was significantly higher compared to that in the (SVD ≥ 25) group. There was a significant negative association between serum TNFR-2 and vitamin D levels in the whole sample. We found significant lower levels of IL-10 in positive-hsCRP group compared to the negative-hsCRP group. In addition, there was a significant negative correlation between the serum vitamin D level and hsCRP in both hsCRP groups. The HDL level was lower in the (SVD < 25) group compared to that in the (SVD ≥ 25) group. Finally, there was a negative correlation between the serum HDL and hsCRP levels in the positive-hsCRP subjects. Conclusion: Based on the findings it can be concluded that serum vitamin D affects HDL and inflammation status. Although serum levels of HDL and inflammation status are both predictors of metabolic syndrome and cardiovascular disease, further studies are needed to prove it, especially in adolescents.

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Section: Introductionmentioning

confidence: 99%

The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents

et al. 2020

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“…Regarding the circulating strains of G2b in Mexico, the most distant with respect to time and substitutions of amino acids are PEDV/MEX/MICH/2013 and PEDV/MEX/JAL/01/2016, with a 99% identity. However, in 2015 in China, the S gene of diverse strains was assessed, yielding a homology between 96.6 and 100% [32]. This result indicates that the strains from this study have not undergone a high rate of mutations, although the antigenic sites have changed.…”

Section: Discussionmentioning

confidence: 67%

“…Changes in the S gene have been related to recurring cases, as in Japan, where a co-infection of PEDV strains with the complete S gene and strains with deletions of amino acids 194-216 in region S1 were identified [31]. However, the neutralizing regions SS2 and 2C10 remain highly conserved, as reported previously in studies performed with strains from Japan in 2014 and China in 2015 [11,32]. Region SS6 does not show mutations in relation to strains of G2b; however, there are changes compared to G1.…”

Section: Discussionmentioning

confidence: 83%

Molecular characterization of the spike gene of the porcine epidemic diarrhea virus in Mexico, 2013–2016

et al. 2017

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In Mexico, the first outbreaks suggestive of the circulation of the porcine epidemic diarrhea virus (PEDV) were identified at the beginning of July 2013. To identify the molecular characteristics of the PEDV Spike (S) gene in Mexico, 116 samples of the intestine and diarrhea of piglets with clinical signs of porcine epidemic diarrhea (PED) were obtained. Samples were collected from 14 farms located in six states of Mexico (Jalisco, Puebla, Sonora, Veracruz, Guanajuato, and Michoacán) from 2013 to 2016. To identify PEDV, we used real-time RT-PCR to discriminate between non-INDEL and INDEL strains. We chose samples according to state and year to characterize the S gene. After amplification of the S gene, the obtained products were sequenced and assembled. The complete amino acid sequences of the spike protein were used to perform an epitope analysis, which was used to determine null mutations in regions SS2, SS6, and 2C10 compared to the sequences of G2. A phylogenetic analysis determined the circulation of G2b and INDEL strains in Mexico. However, several mutations were recorded in the collagenase equivalent (COE) region that were related to the change in polarity and charge of the amino acid residues. The PEDV strain circulating in Jalisco in 2016 has an insertion of three amino acids (LGL) and one change in the antigenic site of the COE region, and strains from the years 2015 and 2016 changed the index of the surface probability, which could be related to the re-emergence of disease outbreaks.

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“…Further carefully controlled experimental study is needed to better understand the observation. Low serum 25(OH)D concentrations have been associated with dyslipidemia, indicated as increased serum levels of TC, LDL-c and TG, and low levels of HDL-c, which could possibly explain the relation with diabetes and cardiovascular diseases [42,43]. Ford et al [44] in their analysis of the third National Health and Nutrition Examination Survey (NHANES) revealed inverse associations between serum 25(OH)D concentrations and TG in healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Relationship of serum Vitamin D concentrations with Adipokines and Cardiometabolic risk among non-Hispanic black type 2 diabetic and non-diabetic subjects: a cross-sectional study

2018

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Background: To report the association of serum 25-hydroxyvitamin D [25(OH)D] and its association with adipokines and cardiometabolic risk factors in Haitian Americans (HA) and African Americans (AA) by ethnicity and type 2 diabetes (T2D) status. Methods: A cross-sectional study in 197 HA (92 with T2D and 102 without T2D) and 200 AA (97 with T2D and 103 without T2D) recruited in South Florida. Serum 25(OH)D concentrations and adipokines were analyzed by ELISA and cardiometabolic risk factors were indexed by obesity, glycemic control, insulin sensitivity, lipid profile, and blood pressure. Results: Controlling for age, BMI, energy intake, smoking status and HOMA2-IR in multivariate linear regression analyses, serum 25(OH)D concentrations were significantly associated with WC (R 2 = 0.760, B = − 0.092, P = 0.027), HbA1C (R 2 = 0.142, B = − 0.012, P = 0.010), and TG (R 2 = 0.159, B = − 1.192, P = 0.003) in only HA without T2D. While serum 25(OH)D concentrations were significantly associated with TC (R 2 = 0.168, B = − 0.329, P = 0.040), log leptin (R 2 = 0.544, B = − 0.007, P = 0.021), and adiponectin (R 2 = 0.144, B = 0.111, P = 0.033), but slightly associated with LDL-c (R 2 = 0.133, B = − 0.278, P = 0.064) in only AA without T2D. Among individuals with T2D, serum 25(OH) D concentrations were marginally associated with IL-6 (R 2 = 0.109, B = 0.076, P = 0.085) in HA with T2D, and there was a trend toward significance with log leptin (R 2 = 0.393, B = − 0.006, P = 0.075) in AA with T2D in regression analysis. Conclusions: The findings that the associations of serum 25(OH)D concentrations with adipokines and cardiometabolic factors differ between HA and AA has clinical and public implications to guide design of T2D preventive strategies that are culturally specific even within the same ethnicity.

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The Associations of Serum Lipids with Vitamin D Status

Cited by 103 publications

References 52 publications

The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents

The Association of Vitamin D Status with Lipid Profile and Inflammation Biomarkers in Healthy Adolescents

Molecular characterization of the spike gene of the porcine epidemic diarrhea virus in Mexico, 2013–2016

Relationship of serum Vitamin D concentrations with Adipokines and Cardiometabolic risk among non-Hispanic black type 2 diabetic and non-diabetic subjects: a cross-sectional study

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