Factors affecting vaccine handling and storage practices among immunization service providers in Ibadan, Oyo State, Nigeria

Dairo, Magbagbeola David; Osizimete, Oyarebu E.

doi:10.4314/ahs.v16i2.27

Cited by 29 publications

(41 citation statements)

References 9 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The substandard vaccine management practices at all levels observed in this current study corroborates the result of previous assessment in Ghana, where even national and regional levels could not meet the acceptable scores of 80% [4]. This has negative impact on storage conditions of vaccines, which can compromise the safety and potency of the vaccines [9] and therefore calls immediate and pragmatic measures to deal with it. Vaccine management is both managerial and operational functions that seek to ensure that adequate and high-quality vaccines are readily available for immunization service delivery [10].…”

Section: Discussionsupporting

confidence: 83%

Effective Vaccine Management: The Case of a Rural District in Ghana

Osei

Ibrahim

Amenuvegbe

2019

Advances in Preventive Medicine

View full text Add to dashboard Cite

Background The Effective Vaccine Management (EVM) initiative provides the platform needed to monitor and assess the vaccine supply chain system to identify strengths and weaknesses of the system at all levels to enhance the development of improvement plan to strengthen the system. This valuation was carried out in the Tolon District of the Northern Region, Ghana. Methods A descriptive valuation of vaccine management was carried out in six vaccine stores in the Tolon District of Northern Ghana. We employed World Health Organization (WHO) assessment tools and procedures which consisted of desk reviews and interviews of cold chain managers to assess vaccine management practices in the district. Five out of the nine global assessment criteria were assessed and a minimum target level required for all criteria to meet the WHO standard was 80%. Results None of the facilities assessed met the WHO benchmark of 80% for all but one criteria assessed. With regards to temperature control, the scores ranged from 42% at Kasuliyili CHPS Centre to 77% at the district store with an average district score of 60%. Stock management ranged between 11% at Wantugu Health Centre and 75% at Nyankpala Health Centre with district average score of 32%. Effective vaccine distribution scores ranged between 13% at Kasuliyili CHPS and 46% at Nyankpala Health Centre with an average district score of 27%. Only Nyankpala Health Centre had an acceptable score of 84% for vaccine management, whereas the lowest score for this indicator was 5% at Tolon Health Centre store with district average score of 53%. Information management and supportive functions scores ranged from 0% at Tolon Health Centre to 26% at the district store with the district average score of 16%. Nineteen (90.5%) of vaccine users had poor knowledge regarding temperature control and vaccine distribution. Conclusion Effective vaccine management knowledge and practices are poor at Tonlon district and calls for urgent and pragmatic approaches such as training and re-training of vaccine users at all levels.

show abstract

Section: Discussionsupporting

confidence: 83%

Effective Vaccine Management: The Case of a Rural District in Ghana

Osei

Ibrahim

Amenuvegbe

2019

Advances in Preventive Medicine

View full text Add to dashboard Cite

show abstract

“…Poor knowledge and perceptions of HCPs about storage and administration of vaccines, as well as the AEFIs possible with vaccine products, have been found to be associated with failures of several immunization programs [18,19]. Vaccines lose their potency when stored at temperatures below and above the cold chain temperature range of 2 degrees Celsius to 8 degrees Celsius [20]. Apart from losing their potency through poor cold chain maintenance, temperature fluctuations could cause vaccine products to change to toxic forms, which could cause AEFIs [21,22].…”

Section: Introductionmentioning

confidence: 99%

Knowledge and Perceptions of Adverse Events Following Immunization among Healthcare Professionals in Africa: A Case Study from Ghana

2019

View full text Add to dashboard Cite

The spontaneous reporting of suspected adverse events following immunization (AEFI) by healthcare professionals (HCPs) is vital in monitoring post-licensure vaccine safety. The main objective of this study was to assess the knowledge and perceptions of AEFIs among healthcare professionals (HCPs) in Africa, using the situation in Ghana as a case study. The study was of a cross-sectional quantitative design, and was carried out from 1 July 2017 to 31 December 2017 with doctors, pharmacists, and nurses as the study participants. A 28-item paper-based questionnaire, delivered by hand to study participants, was the data collection tool in the study. The study was conducted in 4 hospitals after ethical approval was granted. The desired sample size was 686; however, 453 consented to partake in the study. Data were analyzed using SPSS (software version 22, IBM, Armonk, NY, USA), and chi-square and binary logistic regression tests were used for tests of association between HCPs’ characteristics and their knowledge and perceptions. Detailed knowledge of AEFIs was ascertained with a set of 9 questions, with 8 or 9 correctly answered questions signifying high knowledge, 5 to 7 correctly answered questions signifying moderate knowledge, and below 5 correctly answered questions signifying low knowledge. A set of 10 questions also ascertained HCPs’ positive and negative perceptions of AEFI. Results revealed that knowledge of AEFIs was high in 49 (10.8%) participants, moderate in 213 (47.0%) participants, and low in 191 (42.2%) participants. There was no statistically significant correlation between AEFI knowledge and professions. The highest negative perception was the lack of desire to learn more about how to diagnose, report, investigate, and manage AEFI, whereas the lowest was the lack of belief that surveillance improves public trust in immunization programs. There was a general awareness of AEFIs among HCPs in this study. However, negative perceptions and the lack of highly knowledgeable HCPs regarding AEFIs were possible setbacks to AEFI diagnosis, management, prevention, and reporting. More training and sensitization of HCPs on AEFIs and vaccine safety will be beneficial in improving the situation. Future research should focus on assessing the training materials and methodology used in informing HCPs about AEFIs and vaccine safety.

show abstract

“…Availability, affordability, vaccine cost, and lack of cold-chain infrastructure in LMICs are therefore a huge impediment to achieving universal vaccination against HPV and toward reducing the global burden of cervical cancer. 33 An alternative that has been well researched by us and others is to formulate vaccines into a dry form. [20][21][22][23][24][25]34,35 An optimum vaccine formulation in a dry form with stabilizing excipients will eliminate the need for uninterrupted cold-chain and significantly reduce the overall cost of a vaccine.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 Two prophylactic vaccines, all comprised of virus-like particles (VLPs) assembled from recombinant L1, the HPV major capsid protein, are available commercially that protect against the HPV types associated with a high percentage of cancers. Cervarix® (bivalent, GlaxoSmithKline, London, UK) protects against HPV16 and HPV18 while Gardasil® 9 (nonavalent HPV, Merck & Co., NJ, USA) protects against HPV6, 11,16,18,31,33,45,52, and 58. It is predicted that Gardasil® 9 will provide protection against the HPV types that causẽ 90% of cervical cancer cases.…”

Section: Introductionmentioning

confidence: 99%

“…[20][21][22] In this study, we spray-dried the commercially available Gardasil® 9 vaccine with stabilizing excipients. Gardasil® 9 is made up of nine VLPs (derived from HPV6, 11,16,18,31,33,45,52, and 58) absorbed on an aluminum adjuvant (amorphous aluminum hydroxyphosphate sulfate). We evaluated the immunogenicity and protective efficacy of the vaccine in mice, immediately after spray drying and following storage for three months at 4°C, 25°C, and 40°C.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the thermal stability and the protective efficacy of spray-dried HPV vaccine, Gardasil® 9

Kunda

Peabody

Zhai

et al. 2019

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

High-risk human papillomavirus (HPV) types are responsible for nearly all cases of cervical cancers. Cervarix® and Gardasil® 9 are the current prophylactic vaccines available that protect against the majority of HPVs associated with cancer. Although these vaccines are highly effective, HPV vaccine implementation has been slow, particularly in low-and-middle income countries. Major barriers to the widespread availability of the HPV vaccines is its cost and the requirement for continuous refrigeration (2-8°C). Here, we used spray drying along with stabilizing excipients to formulate a thermostable Gardasil® 9 vaccine. We evaluated the immunogenicity and protective efficacy of the vaccine in mice immediately after spray drying and following storage for three months at 4°C, 25°C, and 40°C. The immunogenicity studies were performed using Gardasil® 9 as a whole antigen, and not individual HPV types, for ELISA. At the dose tested, the spray dried vaccine conferred protection against HPV following storage at temperatures up to 40°C. In addition to the spray-dried vaccine, our studies revealed that the Gardasil® 9 vaccine, as currently marketed, may be stored and transported at elevated temperatures for up to 3 months without losing efficacy, especially against HPV16. This study is critical, as a thermostable vaccine will decrease vaccine cost associated with cold-chain maintenance and could increase vaccine access and coverage, especially in remote regions of the world.

show abstract

Factors affecting vaccine handling and storage practices among immunization service providers in Ibadan, Oyo State, Nigeria

Cited by 29 publications

References 9 publications

Effective Vaccine Management: The Case of a Rural District in Ghana

Effective Vaccine Management: The Case of a Rural District in Ghana

Knowledge and Perceptions of Adverse Events Following Immunization among Healthcare Professionals in Africa: A Case Study from Ghana

Evaluation of the thermal stability and the protective efficacy of spray-dried HPV vaccine, Gardasil® 9

Contact Info

Product

Resources

About