Factors affecting the quality of life in patients with epilepsy in Seoul, South Korea

Choi-Kwon, Smi; Chung, Chun Kee; Kim, H.; Lee, S.; Yoon, Sang Min; Kho, Hong‐Seop; Oh, Juhwan

doi:10.1046/j.1600-0404.2003.00151.x

Cited by 146 publications

(119 citation statements)

References 22 publications

(35 reference statements)

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“…The differences were highly statistically significant on ANOVA (p value<0.001).This shows that education improves quality of life. Similar results were reported by Choi-Kwon S et al 11 Frequency of seizures per month was positively correlated with QOLIE-9 total scores (Pearson Correlation 0.622) and was highly statistically significant (p value <0.001), as also reported by Djibuti et al and Thomas et al 2,10 Duration of illness positively correlated with QOLIE-9 total scores (Pearson Correlation 0.118) and but was statistically insignificant (p value 0.242). Szaflarski et al found poor quality of life with increase duration of illness.…”

Section: Discussionsupporting

confidence: 88%

Quality of life in epilepsy

Singh¹,

Pandey

2017

Int J Res Med Sci

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Background: The quality of life (QOL) evaluation is a relatively new measure to evaluate the outcome of epilepsy. Many factors influence the quality of life of people with epilepsy, including seizure severity, stigma, fear, and the presence of cognitive or psychiatric problems. QOL is influenced by biological factors as well as cultural, social and religious beliefs and values. This study was planned to find out the impact of epilepsy on quality of life of epileptic patients.Methods: The study was conducted in the epilepsy clinic of department of neurology at a tertiary care hospital over a period of one year.101 patients were included after fulfilling the inclusion criteria. All the patients seeking treatment in the OPD were screened, assessed and then all procedures were fully explained to them. History regarding name, age sex, socio-demographic profile and detailed history regarding seizure disorder was taken from both the patient and the reliable informant. Bengali version of QOLIE-9 was used to assess the quality of life.Results: One hundred and one patients with epilepsy consisting of 70 men (69.3%) and 31 women (30.7%) were included. Their ages ranged from 15 to 52, the mean age being 26.17 (SD = 7.84). Out of the 101 patients, 65 patients (64.4%) were suffering from partial epilepsies and 36 patients (35.6%) were suffering from generalized epilepsies. Mean QOLIE-9 total scores were 16.66, 19.74, 20.13 and 24.00 in married, widows, unmarried and separated individuals respectively. The differences in the means were statistically significant on ANOVA (p value 0.002). Mean QOLIE-9 total scores were 27.75, 19.64, 19.65, 18.14 and 18.00 in primary, secondary, higher secondary, graduate and postgraduate individuals respectively. The differences were highly significant statistically on ANOVA (p value<0.001). Frequency of seizures per month was positively correlated with QOLIE-9 total scores (Pearson Correlation 0.622) and was highly statistically significant (p value<0.001).Conclusions: Frequent seizures, lower education level and single status are associated with lower quality of life in persons with epilepsy.

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Section: Discussionsupporting

confidence: 88%

Quality of life in epilepsy

Singh¹,

Pandey

2017

Int J Res Med Sci

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“…In one study, AnxD or major depressive episode (MDE) had a comparable negative impact on quality of life measured with the Quality of Life in Epilepsy Inventory-89 (QOLIE-89) while comorbid occurrence of both mood and anxiety disorders yielded a worse impact 12 . In another study of 154 outpatient adults with epilepsy, presence of anxiety symptoms was the most important factor in explaining a worse QoL 13 .…”

Section: Introductionmentioning

confidence: 94%

Screening of anxiety and quality of life in people with epilepsy

Özmen

Leibetseder

Cock

et al. 2017

Seizure

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PURPOSEUp to 60% of people with epilepsy (PwE) have psychiatric comorbidity including anxiety.Anxiety remains under recognized in PwE. This study investigates if screening tools validated for depression could be used to detect anxiety disorders in PWE. Additionally it analyses the effect of anxiety on QoL. METHODS261 participants with a confirmed diagnosis of epilepsy were included. Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and Emotional Thermometers (ET), both validated to screen for depression were used. Hospital Anxiety and Depression ScaleAnxiety (HADS-A) with a cut off for moderate and severe anxiety was used as the reference standard. QoL was measured with EQ5-D. Sensitivity, specificity, positive and negative predictive value and ROC analysis as well as multivariate regression analysis were performed. RESULTSPatients with depression (n=46) were excluded as multivariate regression analysis showed that depression was the only significant determinant of having anxiety in the group. Against HADS-A, NDDI-E and ET-7 showed highest level of accuracy in recognizing anxiety with ET7 being the most effective tool. QoL was significantly reduced in PwE and anxiety. CONCLUSIONSOur study showed that reliable screening for moderate to severe anxiety in PwE without comorbid depression is feasible with screening tools for depression. The cut off values for anxiety are different from those for depression in ET7 but very similar in NDDI-E. ET7 can be applied to screen simultaneously for depression and "pure" anxiety. Anxiety reduces significantly QoL. We recommend screening as an initial first step to rule out patients who are unlikely to have anxiety.Highlights  Moderate to severe anxiety is a frequent comorbidity in epilepsy, in our cohort prevalence was 26,4%  Depression was the only significant determinant for anxiety, prevalence of anxiety in non-depressed PwE was 15,8%. Screening for anxiety independent from depression can be achieved with the ET7 tool.

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“…Многие авторы отмечают, что при применении в качестве доба-вочной терапии ПЭП последнего поколения, отмечается лучший профиль переносимости политерапии [77,78]. Следует отметить, что есть и другие данные: согласно ис-следованиям, проведенным в разных странах [79][80][81] у больных эпилепсией, получавших политерапию, отмеча-лись более низкие показатели качества жизни (КЖ), а при переводе с политерапии на монотерапию показатели КЖ улучшались [78,82,83].…”

Section: вероятность эффективности терапии при первой неудачеunclassified