Factors affecting the course and severity of adult acne. Observational cohort study

Chlebuś, Ewa; Chlebuś, Marcin

doi:10.1080/09546634.2017.1329500

Cited by 21 publications

(23 citation statements)

References 26 publications

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“…Our study showed that 56.6% patients in the study population presented with late onset acne while 43.33% females suffered from persistent acne which is different from other studies where a majority of patients were in the persistent group. 6,8,9 Acne was mild to moderate in severity in our cohort which was in consonance with the results of Kaminsky et al 9 We noted a significantly different clinical and hormonal difference between the two subgroups (Tables 1 and 2). The mean age of patients with late onset acne was significantly higher than the persistent ones which logically ensues from the late age of presentation (Table 1).…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 82%

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A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females

et al. 2020

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Background Adult acne has been classified into two major subtypes: “persistent acne” and “late onset acne”. A surrogate marker of hyperandrogenism (HA) in adult female acne is the presence of clinical signs of HA and biochemical hyperandrogenemia. We compared the clinical and hormonal profiles of the two acne subtypes and evaluated the likely source of androgen excess – ovarian or adrenal. Methods Female acne patients 25 years of age and older were evaluated for clinical HA. Hormonal assessment included total testosterone (TT), sex hormone binding globulin (SHBG), free androgen index (FAI), anti‐Mullerian hormone (AMH), 17‐hydroxyprogesterone (17‐OHP), dehydroepiandrosterone sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), and prolactin. DHEAS and 17‐OHP represented adrenal androgens and AMH indicated ovarian reserve. Results Of 120 cases, clinical HA was seen in 71.67% while biochemical hyperandrogenemia was detected in only 18.33% of patients. Though late onset was more common in adult acne patients (56.6%), the persistent acne subgroup (43.33%) had a younger age at onset, a past history of adolescent acne (51.92%), truncal predilection (44.23%), polycystic ovary syndrome (PCOS) (44.23%), significant presence of irregular menses (40.38%) and hirsutism (57.69%), and increased TT (13.46%), 17‐OHP (76.92%), AMH (44.23%), and increased LH/FSH (15.38%) ratio. PCOS was seen more in the persistent acne patients with clinical HA and increased 17‐OHP levels. Conclusion Persistent acne patients had marked clinical HA, PCOS, and hormonal abnormalities necessitating an endocrinological evaluation. As a corollary, this subgroup would benefit from antiandrogen therapy.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 82%

A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females

et al. 2020

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“…3 A dramatic improvement of the skin appearance on the application site of imiquimod has been observed in patients with XP. [2][3][4][5][6][7] We report two children with XP treated with imiquimod 5% cream, establishing a chemoprophylaxis for cancerization field. Patient 1: A diagnosis of XP was established in a 5-yearold boy with a BCC on his eyelid and multiple hyperpigmented macules on his face (Fig.…”

mentioning

confidence: 99%

A retrospective case series of referrals to our psychodermatology clinic 2009–2016

Roche

Switzer

Ramsay

2018

Acad Dermatol Venereol

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“…It has been shown that acne lesions in women aged 30 to 40 occur more frequently in city dwellers, with higher education, performing intellectual work, and not reporting hormonal disturbances (some women report exacerbation of the symptoms in premenstrual period). This type of AV lesions usually occurs for the first time after the period of maturation in women with negative family history of AV, most frequently involves lower part of the face (mandibular and perioral areas, chin) and neck and usually presents as persistent inflammatory lesions (papules, pustules, more rarely nodules, infiltrations and cysts) resolving mostly with post-inflammatory hyperpigmentation [9].…”

Section: Introductionmentioning

confidence: 99%

“…medication or anabolic steroids used in body building and sports) -may lead to sebaceous glands hypertrophy with increased sebum secretion, increased production of skin surface lipids and increased proliferation of P. acnes [7,8]; (viii) using improper cosmetics -i.e. comedogenic (blocking pilosebaceous units) or aggressive alcoholic cosmetic preparations (which initially cause skin dryness, and thus predispose to sebum overproduction) [9].…”

Section: Introductionmentioning

confidence: 99%

New H2O2 dermocosmetic in acne skin care

Kisiel¹,

Dębowska²,

Dzilińska³

et al. 2018

Our Dermatol Online

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INTRODUCTIONAcne vulgaris (AV) is chronic inflammatory disease of sebaceous glands and hair follicles (so-called folliculosebaceous units) characterized by the presence of both non-inflammatory (i.e. microcomedones, closed comedones and open comedones) and inflammatory lesions (papules, pustules and cysts). AV is the most common skin disease in adolescents, although it is seen more and more often in adults, mostly women. It is estimated that 41% of people aged 25 to 40 suffer from acne lesions for at least 3 to 4 months per year (with a marked predominance in women -female: male ratio of 4:1) [1].AV pathogenesis is complex, involving mostly 4 interdependent pathogenic factors: (i) increased a c t i v i t y o f s e b a c e o u s g l a n d s w i t h s e b u m overproduction; (ii) hyperkeratosis of pilosebaceous duct leading to blockage of pilosebaseous units with excess keratin and sebum, causing comedo formation; (iii) colonization of sebaceous glands ducts with anaerobic bacteria Propionibacterium acnes and increased proliferation of aerobic bacteria Staphylococcus epidermidis and lipophilic yeasts Pityrosporum ovale (which cause irritant action due to free fatty acids derived from hydrolysis of sebum triglycerides); (iv) induction of inflammatory processes in the skin. Other factors involved in the formation of acne lesions include: (i) genetic predisposition (probably polygenic or autosomal dominant with variable penetrance) -genetic factors influence density of androgen receptors in sebaceous glands, 5-α reductase activity, seborrhoea intensity and sebaceous glands size [2,3]; (ii) immunological disturbances -excessive ABSTRACT Background: Acne vulgaris (AV) is a common skin disease with characteristic clinical, chronic course and different etiopathogenesis. AV occurs more and more often among adults, especially women. AV, due to the chronic nature of the skin lesions, often requires many months or even long-term treatment and proper skin care both during the period that does not require administration of drugs, as well as during and after pharmacotherapy. The aim of the study was to evaluate the safety and the anti-acne efficacy of a point-gel containing 2% H2O2 and salicylic acid (0.54%), phytic acid (1%), D-panthenol (1%) and vitamin PP (0.012%). Material and Methods: 24 patients with mild to severe AV used the study product containing hydrogen peroxide for 7 days. The condition of skin patients was assessed instrumentally (VISIA) and clinically by a dermatologist, including assessment of skin lesions visibility in the 10-point analogue scale and the number of particular acne lesions. Results: The product was well tolerated. Dermatological evaluation at day 7 showed a significant decrease in the visibility of acne lesions (P=0.0003) and a significant reduction of number of pustules (P=0.002); an insignificant decrease in numbers of papules and comedones was also observed. Instrumental analysis of VISIA showed insignificant reduction in the number and intensity of skin discolorations, epidermal irregulariti...

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Factors affecting the course and severity of adult acne. Observational cohort study

Abstract: Lifestyle change-related stress, sensitive skin, discontinuation of oral contraceptives and using full-coverage foundations increase severity of AA.

Cited by 21 publications

References 26 publications

A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females

A study comparing the clinical and hormonal profile of late onset and persistent acne in adult females

A retrospective case series of referrals to our psychodermatology clinic 2009–2016

New H2O2 dermocosmetic in acne skin care

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