Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

Parmar, Komal; Patel, Jayvadan K.; Pathak, Yashwant

doi:10.1007/978-3-030-83395-4_14

Cited by 8 publications

(3 citation statements)

References 96 publications

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“…Rapamune (micelles with rapamycin) and Abraxane (albumin with NPs), two other nanobiotechnology-based anticancer medications, have increased anticancer effects and lowered cytotoxicity to normal cells [88]. Cancer cells' intracellular space can be diffused with NPs to produce an EPR effect [89]; When used to trigger apoptosis in cancer cells, biogenic MNPs are particularly successful. It is clear that biogenic AgNPs can activate the caspase-3 intrinsic pathway to trigger apoptosis in malignant cells more effectively than healthy ones.…”

Section: Anticancer Applicationmentioning

confidence: 99%

Nanobiomaterials: exploring mechanistic roles in combating microbial infections and cancer

Rawat,

Ahmad,

Raturi

et al. 2023

Discover Nano

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The initiation of the "nanotechnology era" within the past decade has been prominently marked by advancements in biomaterials. This intersection has opened up numerous possibilities for enhancing the detection, diagnosis, and treatment of various illnesses by leveraging the synergy between biomaterials and nanotechnology. The term "nano biomaterials" referring to biomaterials featuring constituent or surface feature sizes below 100 nm, presents a realm of extraordinary materials endowed with unique structures and properties. Beyond addressing common biomedical challenges, these nano biomaterials contribute unprecedented insights and principles that enrich our understanding of biology, medicine, and materials science. A critical evaluation of recent technological progress in employing biomaterials in medicine is essential, along with an exploration of potential future trends. Nanotechnology breakthroughs have yielded novel surfaces, materials, and configurations with notable applications in the biomedical domain. The integration of nanotechnology has already begun to enhance traditional biomedical practices across diverse fields such as tissue engineering, intelligent systems, the utilization of nanocomposites in implant design, controlled release systems, biosensors, and more. This mini review encapsulates insights into biomaterials, encompassing their types, synthesis methods, and the roles of organic and inorganic nanoparticles, elucidating their mechanisms of action. Furthermore, the focus is squarely placed on nano biomaterials and their versatile applications, with a particular emphasis on their roles in anticancer and antimicrobial interventions. This review underscores the dynamic landscape of nanotechnology, envisioning a future where nano biomaterials play a pivotal role in advancing medical applications, particularly in combating cancer and microbial infections.

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Section: Anticancer Applicationmentioning

confidence: 99%

Nanobiomaterials: exploring mechanistic roles in combating microbial infections and cancer

Rawat,

Ahmad,

Raturi

et al. 2023

Discover Nano

View full text Add to dashboard Cite

show abstract

“…As shown in Figure 3, there are many criteria to consider when designing a nanoparticlebased vaccine. Nanoparticles with the size of less than ten nanometers are usually reported to be excreted by the kidneys, while larger particles are excreted by the liver [83]. Particles larger than 200 nm have also been shown to be able to be repelled by the spleen as long as they have good flexibility [84].…”

Section: Figure 3 Various Chemical and Physical Properties That Can D...mentioning

confidence: 99%

Nanoparticles for Coronavirus Control

Akbarian

Uversky

2022

Nanomaterials

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More than 2 years have passed since the SARS-CoV-2 outbreak began, and many challenges that existed at the beginning of this pandemic have been solved. Some countries have been able to overcome this global challenge by relying on vaccines against the virus, and vaccination has begun in many countries. Many of the proposed vaccines have nanoparticles as carriers, and there are different nano-based diagnostic approaches for rapid detection of the virus. In this review article, we briefly examine the biology of SARS-CoV-2, including the structure of the virus and what makes it pathogenic, as well as describe biotechnological methods of vaccine production, and types of the available and published nano-based ideas for overcoming the virus pandemic. Among these issues, various physical and chemical properties of nanoparticles are discussed to evaluate the optimal conditions for the production of the nano-mediated vaccines. At the end, challenges facing the international community and biotechnological answers for future viral attacks are reviewed.

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“…The contrast agents that fail to reach the lesion sites can be cleared from the body by hepatobiliary, MPS, or renal clearance pathways [63][64][65], avoiding the false positive signals and unpredictable toxicity caused by organ retention [51,66,67]. Considering the clearance principle of biomaterials, the chemical composition, size, shape, and surface charge of biomaterials have a crucial impact on biological distribution and clearance [68][69][70]. Large-sized materials would be mainly assimilated by MPS because of the plasma protein adsorption on the materials, triggering sequestration by MPS.…”

Section: Introductionmentioning

confidence: 99%

Clearance pathways of near-infrared-II contrast agents

Yang¹,

Li²,

Xiao³

et al. 2022

Theranostics

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Near-infrared-II (NIR-II) bioimaging gradually becomes a vital visualization modality in the real-time investigation for fundamental biological research and clinical applications. The favorable NIR-II contrast agents are vital in NIR-II imaging technology for clinical translation, which demands good optical properties and biocompatibility. Nevertheless, most NIR-II contrast agents cannot be applied to clinical translation due to the acute or chronic toxicity caused by organ retention in vivo imaging. Therefore, it is critical to understand the pharmacokinetic properties and optimize the clearance pathways of NIR-II contrast agents in vivo to minimize toxicity by decreasing organ retention. In this review, the clearance mechanisms of biomaterials, including renal clearance, hepatobiliary clearance, and mononuclear phagocytic system (MPS) clearance, are synthetically discussed. The clearance pathways of NIR-II contrast agents (classified as inorganic, organic, and other complex materials) are highlighted. Successively analyzing each contrast agent barrier, this review guides further development of the clearable and biocompatible NIR-II contrast agents.

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Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles

Cited by 8 publications

References 96 publications

Nanobiomaterials: exploring mechanistic roles in combating microbial infections and cancer

Nanobiomaterials: exploring mechanistic roles in combating microbial infections and cancer

Nanoparticles for Coronavirus Control

Clearance pathways of near-infrared-II contrast agents

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