Factors affecting incorporation of drug into solid solution with HPMCP during solvent change co-precipitation

Effect of hydrophilic swellable polymers on dissolution enhancement of carbamazepine solid dispersions studied using response surface methodology

“…4 Because of having poor water solubility, its absorption is dissolution rate limited, which often results in irregular and delayed absorption. 5 For improvement of solubility and dissolution rate of poorly soluble drugs, numerous commercially viable techniques such as liquisolid, in which drug in solution state or dissolved drug is adsorbed over insoluble carriers, [6][7][8] nanomorph, a patented technology by Soliqs for controlled crystallization of drug, 9 in situ micronization, 10,11 and coprecipitation using antisolvent, 12 are available. Surfactants can also be used in formulations to improve wettability and solubility of many lipophilic substances.…”

Fast-track to A Solid Dispersion Formulation Using Multi-way Analysis of Complex Interactions

“…During the solid dispersion formulation development phase, many factors originating from both formulation as well as processing can have decisive influence of the physical stability of the drug, 2,3 and the importance of evaluating the combined influence of these factors has been highlighted. 4,5 From a formulation perspective, numerous studies have investigated and found factors such as polymer-to-drug ratio, polymer type, and its molecular weight to have decisive influence for the drug physical stability. [6][7][8] When solid dispersion is prepared using the solvent evaporation method, several studies have highlighted the influence of various process parameters including solvent evaporation rate on solid dispersion physical stability.…”

Development and characterization of matrix pellets prepared by extrusion / sheronization of atenolol

“…This method has been utilized in various branches of science and industry, e.g. food [33], environmental management [34], chemistry [35], and pharmaceutical technology [36][37][38][39]. The mathematically determined effects of different factors are compared by means of this technique, this information being very useful for the application of process analytical technology at the heart of which is the acquisition of a deep understanding of the manufacturing process [40].…”