Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients

Hatori, Takashi; Shirai, Kohji

doi:10.2147/dmso.s80907

Cited by 12 publications

(8 citation statements)

References 43 publications

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“…In previous cross-sectional studies, CAVI is associated with various cardiovascular risk factors. CAVI correlates with high-sensitivity cardiac troponin T [116], renal function [117], non-dipper type hypertension [118], hyperuricemia [119], dyslipidemia [120], coronary calcium [121,122], polyneuropathy in type 2 diabetics [123], paroxysmal atrial fibrillation [124], carotid intima-media [125,126,127,128], and lacunar silent cerebral infarction in patients with atrial fibrillation [129]. In addition, CAVI correlates with skin autofluorescence, which evaluates deposition of advanced glycation end products by detecting light intensity per nanometer between 300 and 420 nm in patients with type 2 diabetes mellitus [130].…”

Section: Cavi and Cardiovascular Risk Factorsmentioning

confidence: 99%

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Namba

Masaki

Takase

et al. 2019

IJMS

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Arterial stiffness is an age-related disorder. In the medial layer of arteries, mechanical fracture due to fatigue failure for the pulsatile wall strain causes medial degeneration vascular remodeling. The alteration of extracellular matrix composition and arterial geometry result in structural arterial stiffness. Calcium deposition and other factors such as advanced glycation end product-mediated collagen cross-linking aggravate the structural arterial stiffness. On the other hand, endothelial dysfunction is a cause of arterial stiffness. The biological molecular mechanisms relating to aging are known to involve the progression of arterial stiffness. Arterial stiffness further applies stress on large arteries and also microcirculation. Therefore, it is closely related to adverse outcomes in cardiovascular and cerebrovascular system. Cardio-ankle vascular index (CAVI) is a promising diagnostic tool for evaluating arterial stiffness. The principle is based on stiffness parameter β, which is an index intended to assess the distensibility of carotid artery. Stiffness parameter β is a two-dimensional technique obtained from changes of arterial diameter by pulse in one section. CAVI applied the stiffness parameter β to all of the arterial segments between heart and ankle using pulse wave velocity. CAVI has been commercially available for a decade and the clinical data of its effectiveness has accumulated. The characteristics of CAVI differ from other physiological tests of arterial stiffness due to the independency from blood pressure at the time of examination. This review describes the pathophysiology of arterial stiffness and CAVI. Molecular mechanisms will also be covered.

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Section: Cavi and Cardiovascular Risk Factorsmentioning

confidence: 99%

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Namba

Masaki

Takase

et al. 2019

IJMS

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“…7 An association between cTnT and N-terminal pro-B-type natriuretic peptide (NT-proBNP) was reported in individuals with the metabolic syndrome. 8 In Black men from the Sympathetic activity and Ambulatory Blood Pressure in Africans (SABPA) cohort, cTnT was also associated with NT-proBNP, which may indicate increased cardiac wall strain in our population group. 9 There is increasing evidence to suggest a role of cardiac stress in the development of neurodegenerative diseases as cTnT and NT-proBNP are independently associated with cognitive decline.…”

Section: Prospective Associations Between Cardiac Stress Glucose Dysmentioning

confidence: 78%

Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men: The Sympathetic activity and Ambulatory Blood Pressure in Africans study

Vuren

Malan

Känel

et al. 2018

Diabetes and Vascular Disease Research

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Objective: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and executive cognitive function prospectively, in a bi-ethnic sex cohort. Methods: Black and White teachers (N = 338, aged 20-63 years) from the Sympathetic activity and Ambulatory Blood Pressure in Africans study were monitored over a 3-year period. Fasting blood samples were obtained for cardiac troponin T, N-terminal brain natriuretic peptide, glycated haemoglobin and the homeostatic model assessment-insulin resistance for insulin resistance. The Stroop colour-word conflict test was applied to assess executive cognitive function at baseline. Results: Over the 3-year period, Black men revealed constant high levels of cardiac troponin T (⩾4.2 ng/L), prediabetes (glycated haemoglobin > 5.7%) and insulin resistance (homeostatic model assessment-insulin resistance >3). %Δ Glycated haemoglobin was associated with %Δ insulin resistance (p < 0.001) and increases in %ΔN-terminal brain natriuretic peptide (p = 0.02) in Black men only. In the latter, baseline Stroop colour-word conflict test was inversely associated with %Δ cardiac troponin T (p = 0.001) and %Δ insulin resistance levels (p = 0.01). Conclusion: Progressive myocyte stretch and chronic myocyte injury, coupled with glucose dysregulation, may interfere with processes related to interference control in Black men.

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“…Sato et al also reported that age, eGFR, and Cornell voltage were significantly associated with hs-cTnT based on multivariate analysis. In addition, other clinical reports indicated a significant relationship between BNP and hs-cTnT [ 1 , 23 ]. The analysis in this study also selected these factors as independent variables for hs-cTnT as a subordinate factor.…”

Section: Discussionmentioning

confidence: 99%

Clinical impact of skin autofluorescence on high-sensitivity troponin T in hypertensive patients

Hatori¹

2017

Clin Hypertens

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BackgroundRecent studies have reported the importance of high-sensitivity troponin T (hs-cTnT) or skin autofluorescence (AF) as a cardiovascular risk factor. However, little is known about the relationship between these two markers. The aim of this study was to clarify the clinical impact of skin AF on hs-cTnT in hypertensive patients, from the perspective of primary prevention of cardiovascular events.MethodsIn total, 457 outpatients on treatment for hypertension [182 men and 275 women; mean (± SD) age, 67 ± 13 y] and with no history of cardiovascular events were enrolled. Hs-cTnT levels and skin AF were measured using commercial devices, and relationships between hs-cTnT levels and various clinical parameters including skin AF were examined.ResultsHs-cTnT was detected in 405 (88.6%) patients. Skin AF was significantly higher in patients with detectable hs-cTnT than in those without detectable hs-cTnT [2.6 ± 0.5 arbitrary units (AU) vs. 2.2 ± 0.5 AU, respectively, p < 0.001]. In patients with detectable hs-cTnT, there was a significantly positive correlation between skin AF and Log-hs-cTnT (r = 0.41, p < 0.001). Furthermore, multiple regression analysis revealed that skin AF was the strongest variable associated with Log-hs-cTnT as a subordinate factor (β = 0.30, p < 0.001).ConclusionsThe results of this study indicate that skin AF is an important determining factor for hs-cTnT elevation in hypertensive patients with no history of cardiovascular events.

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Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients

Cited by 12 publications

References 43 publications

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Arterial Stiffness Assessed by Cardio-Ankle Vascular Index

Prospective associations between cardiac stress, glucose dysregulation and executive cognitive function in Black men: The Sympathetic activity and Ambulatory Blood Pressure in Africans study

Clinical impact of skin autofluorescence on high-sensitivity troponin T in hypertensive patients

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