Clinical impact of skin autofluorescence on high-sensitivity troponin T in hypertensive patients

Hatori, Takashi

doi:10.1186/s40885-017-0076-y

Cited by 5 publications

(5 citation statements)

References 30 publications

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“…Moreover, they also clarified that the AGEs found at the volar side of the lower arm appear to reflect the level of AGEs/RAGEs in the cardiomyocytes. In fact, there are several clinical studies that show significant relationships between skin AF and biomarkers of myocardial injury [13,34]. Although markers of myocardial injury were not evaluated in the present study, previous studies have shown that AGEs/RAGEs are believed to play important roles in the progression of myocardial injury; consequently, HFpEF patients with high skin AF may be particularly prone to becoming hospitalized due to HF.…”

Section: Discussionmentioning

confidence: 82%

Skin Autofluorescence as a Predictor of First Heart Failure Hospitalization in Patients With Heart Failure With Preserved Ejection Fraction

Hatori¹

2020

Cardiol Res

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Background: An autofluorescence (AF) reader can be used to diagnose skin AF non-invasively by measuring local accumulation of advanced glycation end-products. A number of studies have investigated the relationships between skin AF and cardiovascular disease. However, data regarding the usefulness of skin AF as a predictor of chronic heart failure remain limited. This prospective study aimed to elucidate the usefulness of skin AF as a predictor of first heart failure (HF) hospitalization in patients with HF with preserved ejection fraction (HFpEF).Methods: A total of 412 outpatients with HFpEF with no history of HF hospitalization were enrolled. Patients were assigned to either the low (group L; skin AF ≤ 2.9 arbitrary units (AU); n = 303) or the high (group H; skin AF ≥ 3.0 AU; n = 109) group according to optimal skin AF cut-off levels determined using receiver operating characteristic curves. Clinical parameters and the usefulness of skin AF as a predictor of first HF hospitalization were evaluated. Results:The E/e' ratio as a marker of left ventricular diastolic function was significantly higher in group H patients than in group L patients at baseline (group H, 11.8 ± 3.8; group L, 10.6 ± 3.3; P = 0.002). During the 72.7-month follow-up period, 43 HF cases were hospitalized (group L, 15 cases; group H, 28 cases; P < 0.001, log-rank test). Multivariate Cox regression analyses revealed that group H exhibited a significantly higher risk of first HF hospitalization than did group L (hazard ratio, 2.26; 95% confidence interval, 1.21 -3.52; P = 0.014). Conclusions:The present study demonstrated that skin AF can predict the risk of first HF hospitalization in patients with HFpEF. Prospective studies, including intervention therapies, are required to validate our observations.

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Section: Discussionmentioning

confidence: 82%

Skin Autofluorescence as a Predictor of First Heart Failure Hospitalization in Patients With Heart Failure With Preserved Ejection Fraction

Hatori¹

2020

Cardiol Res

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“…Recent basic and clinical studies have indicated a crucial role of AGEs or receptor of AGEs for arterial aging [29-31]. Researchers have also reported the clinical usefulness of skin AF as a cardiovascular risk factor [32-34]. The present results also indicate an independent association of skin AF and PI of the CCA or the CAVI, suggesting that the accumulation of AGEs in the arterial vessel wall contributes to systemic arterial dysfunction, including that of the cerebral vessels in patients with cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 99%

Relationships Between the Cardio-Ankle Vascular Index and Pulsatility Index of the Common Carotid Artery in Patients With Cardiovascular Risk Factors

Hatori¹

2019

J Clin Med Res

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Background Pulsatility index (PI) is a hemodynamic parameter determined using Doppler sonography; it reflects the degree of peripheral vascular resistance. Moreover, researchers have reported significant relationships between an increase in the PI of the common carotid artery (CCA) and ischemic stroke. This cross-sectional study aimed to clarify the relationships between cardio-ankle vascular index (CAVI) as a marker of arterial stiffness and the PI of the CCA in patients with cardiovascular risk factors for the primary prevention of ischemic stroke. Methods A total of 405 outpatients undergoing treatment for cardiovascular risk factors (152 men and 253 women; mean age ± standard deviation, 64 ± 9 years) with no history of cardiovascular events, including ischemic stroke, were enrolled. The CAVI and the PI of the CCA were measured using commercial devices, and their relationships to various clinical parameters were examined. Results A significant positive correlation was observed between the CAVI and the PI of the CCA (r = 0.44, P < 0.001). Further, multiple regression analysis revealed that the CAVI (β = 0.19, P < 0.001) was selected as independent factor for PI of the CCA as a subordinate factor. Meanwhile, high-sensitivity C-reactive protein, as an inflammation marker, and skin autofluorescence, as a marker of advanced glycation end products in the tissues, were selected as independent variables for either the CAVI or the PI of the CCA as a subordinate factor. The receiver-operating characteristic curve analysis indicated that the cut-off point of the CAVI for high PI of the CCA (> 1.60) as a risk value of stroke incidence by previous report was 9.1 (area under the curve = 0.750, P < 0.001). Conclusion The present results indicate that the CAVI reflects cerebrovascular resistance in patients with cardiovascular risk factors. Moreover, the risk value of the CAVI for ischemic stroke incidence was considered to be 9.1 in these patients.

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“…It was reported that skin AF is associated with AGE-modified tissue collagen levels 38 and cardiac tissue glycation in a human study. 39 Recently, Hitsumoto 28 has shown that skin AF is an important determining factor for the elevation of the cardiac biomarker, hs-cTnT, in hypertensive patients with no history of cardiovascular events. This study found for the first time that skin AF was significantly associated with hs-cTnT but was not associated with NT-proBNP in patients with diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…26,27 A recent study revealed that skin AF is an important determining factor for hs-cTnT elevation in Japanese hypertensive patients with no history of cardiovascular events. 28 However, there have been no studies regarding the relationship between skin AF and hs-cTnT in patients with diabetes. The aim of this study is to evaluate the association between skin AF and cardiovascular biomarkers including hs-cTnT in Japanese subjects with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Skin autofluorescence is associated with high-sensitive cardiac troponin T, a circulating cardiac biomarker, in Japanese patients with diabetes: A cross-sectional study

Yoshioka¹

2018

Diabetes and Vascular Disease Research

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The study aims to evaluate the relationship between skin autofluorescence, a marker of advanced glycated end-products accumulation in tissue, and high-sensitive cardiac troponin T, a cardiovascular biomarker, in Japanese subjects with diabetes. A total of 145 subjects with diabetes and 32 nondiabetic subjects as control attending the outpatient clinic were examined. Skin autofluorescence was measured using the AGE Reader™. Univariate and multivariate regression analyses were used to identify the factors associated with the high-sensitive cardiac troponin T and N-terminal pro-B-type natriuretic peptide values. Skin autofluorescence, high-sensitive cardiac troponin T, and maximum intima-media thickness values were significantly higher in subjects with diabetes than in nondiabetic subjects. Diabetic subjects with skin autofluorescence level⩾2.47 AU (median value) had higher levels of N-terminal pro-B-type natriuretic peptide ( p = 0.006), high-sensitive cardiac troponin T ( p < 0.0001), pentosidine ( p = 0.011) and maximum intima-media thickness ( p = 0.017) compared to those with skin autofluorescence level <2.47 AU. A multivariate regression analysis using variables that were significantly correlated with high-sensitive cardiac troponin T and N-terminal pro-B-type natriuretic peptide, revealed that estimated glomerular filtration rate (β = -0.364, p < 0.001) and skin autofluorescence (β = 0.254, p = 0.0022) were independent determinants of high-sensitive cardiac troponin T, but the variables that were significant in the univariate analysis were no longer predictors for N-terminal pro-B-type natriuretic peptide. Skin autofluorescence measured with the AGE Reader™ could be an easy and noninvasive surrogate marker for identifying diabetic subjects at high risk for subclinical cardiac injury.

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Clinical impact of skin autofluorescence on high-sensitivity troponin T in hypertensive patients

Cited by 5 publications

References 30 publications

Skin Autofluorescence as a Predictor of First Heart Failure Hospitalization in Patients With Heart Failure With Preserved Ejection Fraction

Skin Autofluorescence as a Predictor of First Heart Failure Hospitalization in Patients With Heart Failure With Preserved Ejection Fraction

Relationships Between the Cardio-Ankle Vascular Index and Pulsatility Index of the Common Carotid Artery in Patients With Cardiovascular Risk Factors

Skin autofluorescence is associated with high-sensitive cardiac troponin T, a circulating cardiac biomarker, in Japanese patients with diabetes: A cross-sectional study

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