Factors Affecting Exercise Capacity in Renal Transplantation Candidates on Continuous Ambulatory Peritoneal Dialysis Therapy

Ulubay, Gaye; Akman, Beril; Sezer, Sıren; Çalık, Kevser; Oner, F. Eyuboglu; Özdemir, Nurhan; Haberal, Mehmet

doi:10.1016/j.transproceed.2005.12.107

Cited by 22 publications

(30 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They evaluated CKF patients who underwent CAPD and found decreased MIP in patients with CKF (59.6% of predicted values), compared with controls (82.7% of predicted values). Other authors 14,33,35 have also found results similar to those found in the present study. There is a consensus that respiratory muscle strength is decreased, and the pathogenesis of this condition is similar to what is observed in peripheral muscles.…”

Section: Discussionsupporting

confidence: 93%

“…The three groups were within the normal range (>80% of predicted), but with lower values than in the CG, thus showing that patients with CKF undergoing dialysis and kidney transplant patients have limitations to their ventilatory capacity. There has only been one report of this parameter in evaluating lung function 35 in patients with CKF. However, that author did not compare the value obtained with normal values.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

Cury¹,

Brunetto²,

Aydos

2010

Rev. bras. fisioter.

View full text Add to dashboard Cite

Objective: To evaluate lung function and functional capacity in patients with chronic kidney failure (CKF) undergoing dialysis and in patients after kidney transplant. Methods: Seventy-two participants were evaluated: 32 patients with CKF on dialysis (DG) for at least six months, ten patients who had kidney transplants (TG) at least six months earlier, and 30 healthy subjects as a control group (CG). all groups were evaluated using spirometry, with maximum inspiratory pressure (mIP) and maximum expiratory pressure (mEP), and using the six-minute walking test (6mWT). The SPSS 12.0 software was used for statistical analysis, with a minimum significance level of α<0.05. Results: There was a decreased lung function in the DG for FVC, FEV1, mVV, VC, mIP and mEP, and decreased FEV1 and mVV in the TG compared to the CG (one-way aNOVa/Fisher's post-hoc; p<0.01). There was also an association (chi-square) between decreased mIP and belonging to the DG ‫,5.0=ג(‬ p<0.001), between lower performance in the 6mWT for the DG and TG (p<0.01) compared to the CG (one-way aNOVa/Fisher's post-hoc), and between mIP and mEP (Pearson's coefficient; r=0.752; p<0.01). Conclusions:Patients with CKF undergoing dialysis showed impaired functional capacity and lung function that were not completely reverted in the kidney transplant patients.Key words: dialysis; kidney transplant; spirometry; respiratory muscles; functional capacity. ResumoObjetivo: avaliar a função pulmonar e a capacidade funcional em pacientes com insuficiência renal crônica (IRC) em hemodiálise e em pacientes após transplante renal. Métodos: Foram avaliados 72 indivíduos, sendo 32 pacientes com IRC em hemodiálise (GD) há mais de 6 meses, 10 pacientes transplantados renais (GT) há, pelo menos, 6 meses e 30 sujeitos saudáveis para grupo controle (GC). Todos os grupos foram avaliados utilizando espirometria, pressões inspiratória (PImax) e expiratória (PEmax) máximas e teste da caminhada em seis minutos (TC6min). Para análise estatística, foi utilizado o programa SPSS 12.0, com nível mínimo de significância α<0,05. Resultados: Foram encontrados resultados estatisticamente significativos (p<0,01) para: diminuição da função pulmonar no GD para Capacidade vital forçada (CVF), Volume expirado forçado (VEF1), Ventilação voluntária máxima (VVm), Capacidade vital (CV), PImax, PEmax e, para o GT, diminuição do VEF1 e VVm, quando comparados ao GC (aNOVa uma via/post hoc Fischer); associação (qui-quadrado) entre diminuição da PImax e pertencer ao GD ‫,5,0=ג(‬ p<0,001); menor desempenho no TC6min no GD e GT (p<0,01) quando comparados ao GC (aNOVa uma via/post hoc Fischer). Encontrou-se correlação significativa (coeficiente de Pearson) entre PImax e PEmax (r=0,752, P<0,01). Conclusões: Pode-se concluir que existem alterações na capacidade funcional e na função pulmonar do paciente com IRC em hemodiálise, as quais são indicativas de prejuízos funcionais que não se apresentam completamente revertidos no paciente transplantado renal.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

Cury¹,

Brunetto²,

Aydos

2010

Rev. bras. fisioter.

View full text Add to dashboard Cite

show abstract

“…In the present study, the patients' reduced ability to extract oxygen corresponds to previously reported findings [18][19][20].…”

Section: Discussionsupporting

confidence: 92%

“…Oxygen exchange capacity appeared to be unmatched or perhaps intrinsic mitochondrial function and regulation (abnormal mitochondrial function) were altered significantly in our ESRD patients due to physical inactivity or pathological status. In addition, it is possible that the inability of skeletal muscles to extract oxygen from the arterial blood was due to considerably below-normal oxygen conductance from the muscle capillary to the mitochondria [19]. The latter is most likely associated with poor muscle microcirculatory network and capillarymyofiber dissociation due to uremic myopathy [20].…”

Section: Discussionmentioning

confidence: 99%

What Maintains the Metabolic Cost at Peak Aerobic Exercise in End Stage Renal Disease Patients?

Saghiv¹,

Ben‐Sira²,

Goldhammer³

et al. 2017

J Clin Exp Cardiolog

View full text Add to dashboard Cite

Background: End-stage renal disease (ESRD) reduces performance of cardiopulmonary function and peak oxygen uptake (VO 2 peak). The possible roles of oxygen delivery and oxygen extraction as limiting factors of exercise tolerance in ESRD patients were assessed. Methods:A cross-sectional study was conducted with twenty-two ESRD patients who underwent a peak cardiopulmonary and echocardiograph exercise test via leg cycle ergometry.Results: During exercise, elevated lactic acid occurred at a mean workload of 68.6 ± 5.7 Watts, corresponding to 78% of their respective peak work capacity. At peak exercise, in all measured variables except for systolic blood pressure, ESRD patients did not achieve normally predicted values. Heart rate, left ventricular end diastolic and systolic volumes, stroke volume, cardiac output, VO 2 peak, arteriovenous oxygen difference, and workload were below normal values, while diastolic blood pressure, mean blood pressure and total peripheral resistance were above normal values. Conclusions:In ESRD patients, values for both oxygen delivery and extraction were far below the recorded values in normal. This suggests diminished central cardiopulmonary responses as well as reduced peripheral capacity to extract oxygen at the muscle level. Findings support the concept and possible importance of exercise rehabilitation programs in the approach for treatment of ESRD patients.

show abstract

“…Pacientes com IRT sofrem de um conjunto de alterações em vários sistemas orgânicos, denominado de "síndrome urêmica" (5) , o qual envolve uremia, anemia, doenças cardiopulmonares (6) , alterações metabóli-cas, disfunção musculoesquelética (miopatia urêmica) (7) , comprometimento físico, imunológico e psíquico (5,8) . Esse fenômeno compromete a qualidade de vida e limita as atividades de vida diária, com aumento da taxa de mortalidade nessa população (9)(10)(11) . A redução das medidas de pressão inspiratória e expiratória máxima (8) , representando a fraqueza muscular respiratória em pacientes com IRT, está associada à redução da capacidade funcional (11,12) e da qualidade de vida (13)(14)(15) .…”

Section: Introductionunclassified

Força muscular respiratória e capacidade funcional na insuficiência renal terminal

Dipp

Silva

Signori

et al. 2010

Rev Bras Med Esporte

View full text Add to dashboard Cite

RESUMOObjetivo: Verificar a associação da força muscular respiratória com a capacidade funcional, força proximal de membros inferiores e variáveis bioquímicas em pacientes em hemodiálise (HD). Métodos: Participaram deste estudo 30 indivíduos (18 homens), com 53,4 ± 12,9 anos e tempo de HD de 41,1 ± 55,7 meses. Foram avaliados pressão inspiratória máxima (PImax), pressão expiratória máxima (PEmax), distância percorrida no teste de caminhada de seis minutos (6MWT), número de repetições no teste de sentar-e-levantar em 30 segundos (TSL) e registrados os exames bioquímicos de rotina no serviço. Resultados: Houve diminuição da PEmax em relação aos valores preditos (p = 0,015) e redução na distância percorrida no 6MWT quando comparados com equações de predição (p < 0,001). O logPImax e o logPEmax correlacionaram-se com o número de repetições no TSL (r = 0,476, p = 0,008; r = 0,540, p = 0,002, respectivamente), e com os níveis séricos de fósforo (r = 0,422, p = 0,020; r = 0,639, p < 0,001, respectivamente). A distância no 6MWT correlacionou-se com o logPEmax (r = 0,511; p = 0,004) e com o número de repetições no TSL (r = 0,561; p = 0,001). Conclusão: A redução da PEmax em pacientes com IRT em HD está associada à capacidade funcional, força proximal de membros inferiores e níveis de fósforo sérico, podendo representar, pelo menos em parte, o baixo desempenho físico-funcional desses pacientes.Palavras-chave: músculos respiratórios, insuficiência renal crônica, hemodiálise. ABSTRACTObjective: to evaluate the association of respiratory muscle strength with functional capacity, lower limb strength and biochemical variables in hemodialysis (HD) patients. Methods: a cross-sectional study involving 30 patients (18 male), 53.4 ± 12.9 years, 41.1 ± 55.7 months on HD therapy. Maximal inspiratory pressure (PImax), maximal expiratory pressure (PEmax), distance completed in a six-minute walk test (6MWT) and number of repetitions in sit-and-stand test (STST) were evaluated. The biochemical variables were recorded in the database routine work service. Results: LogEPmax and 6MWT values were significantly lower than the predicted values (p = 0.015; p < 0.001, respectively). logPImax and logPEmax were correlated with number of repetitions in STST (r = 0.476, p = 0.008; r = 0.540, p = 0.002, respectively) and with phosphorus blood levels (r = 0.422, p = 0.020; r = 0.639, p < 0.001, respectively). 6MWT was correlated with logPEmax (r = 0.511; p = 0.004) and with number of repetitions in STST (r = 0.561; p = 0.001). Conclusion: PEmax reduction in patients with ESRD on HD is associated with functional capacity, lower limb strength and phosphorus blood levels, and may at least partly represent the low physical and functional performance of these patients.

show abstract

Factors Affecting Exercise Capacity in Renal Transplantation Candidates on Continuous Ambulatory Peritoneal Dialysis Therapy

Cited by 22 publications

References 28 publications

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

Efeitos negativos da insuficiência renal crônica sobre a função pulmonar e a capacidade funcional

What Maintains the Metabolic Cost at Peak Aerobic Exercise in End Stage Renal Disease Patients?

Força muscular respiratória e capacidade funcional na insuficiência renal terminal

Contact Info

Product

Resources

About