1980
DOI: 10.1007/bf00290486
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Factors affecting E-rosette forming ability in peripheral lymphocytes of insulin dependent diabetics

Abstract: Poorly controlled insulin dependent diabetics showed impaired E-rosette forming ability compared to sex and age matched normal controls (34.8 + 3.1, n = 31 vs 55.5 _+ 1.7, n = 33; p < 0.001; mean + SEM). The reduction of E-rosette cells % was not related to the duration of diabetes, nor to fasting blood glucose levels. Incubation of lymphocytes from a subsequent series of 17 insulindependent diabetics with insulin (100 ~tU/ml) plus glucose (100 mg/100 ml) significantly increased Erosette formation (37.6 _+ 3.3… Show more

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Cited by 7 publications
(2 citation statements)
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References 25 publications
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“…Cells of the mono cyte-macrophage series, however, have additional roles of antigen presentation and immunoregulation, and impairment of monocyte function may result in wider immunological deficiencies, including defects in cell-mediated immunity. Indeed, such defects have been reported in patients with alcoholic cirrhosis [49,56], uraemia [6,30,39,45] and perhaps in diabetes mellitus, although this remains controversial [11,51], The results of the present studies allow us to dem onstrate the feasibility of measuring adherence in clinical research, and that the nylon fibre microcol umn technique is readily applicable to such investiga tions. Most laboratory tests for phagocyte function include the use of a stimulus to activate phagocytes, e.g.…”
Section: Discussionmentioning
confidence: 62%
See 1 more Smart Citation
“…Cells of the mono cyte-macrophage series, however, have additional roles of antigen presentation and immunoregulation, and impairment of monocyte function may result in wider immunological deficiencies, including defects in cell-mediated immunity. Indeed, such defects have been reported in patients with alcoholic cirrhosis [49,56], uraemia [6,30,39,45] and perhaps in diabetes mellitus, although this remains controversial [11,51], The results of the present studies allow us to dem onstrate the feasibility of measuring adherence in clinical research, and that the nylon fibre microcol umn technique is readily applicable to such investiga tions. Most laboratory tests for phagocyte function include the use of a stimulus to activate phagocytes, e.g.…”
Section: Discussionmentioning
confidence: 62%
“…In this report, we have applied this technique to the study of diseases in which increased susceptibility to infection and phagocytic dysfunctions are well-docu mented features; these are diabetes mellitus [3,5,11,23,35,37,42,48,51]. alcoholic cirrhosis [10,15,17,26,34,49,52,55,56] and uraemia [1,4,6,25,30,36,38,39,45,46], Many of our patients were elderly, and although phagocytic cell functions do not seem to de cline to any extent with age [20,21], elderly patients were included in this study to act as another set of controls, and also because no report is available on neutrophil adherence [41], and only one report [22] is available on monocyte adherence in such patients.…”
Section: Introductionmentioning
confidence: 99%