1984
DOI: 10.1016/0090-1229(84)90272-1
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Alterations in immunological function in streptozotocin-induced murine diabetes mellitus: Correction by islet cell transplantation

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Cited by 7 publications
(12 citation statements)
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“…Our data do not determine whether the hyporeactive humoral immunity is T- or B-cell intrinsic, although others have reported normal T-independent but impaired T-dependent antibody responses in the streptozotocin model (3). Our finding of selective impairment of humoral versus cellular immunity in chronic hyperglycemia differs from previously published results in streptozotocin (3,5) and obese models of diabetes (6,10,11), which indicated impairment of both cellular and humoral immunity in diabetic animals. Diabetes-independent immune modulating effects of streptozotocin and obesity could potentially explain why cellular immunity is decreased in those models but remains normal in Akita mice.…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…Our data do not determine whether the hyporeactive humoral immunity is T- or B-cell intrinsic, although others have reported normal T-independent but impaired T-dependent antibody responses in the streptozotocin model (3). Our finding of selective impairment of humoral versus cellular immunity in chronic hyperglycemia differs from previously published results in streptozotocin (3,5) and obese models of diabetes (6,10,11), which indicated impairment of both cellular and humoral immunity in diabetic animals. Diabetes-independent immune modulating effects of streptozotocin and obesity could potentially explain why cellular immunity is decreased in those models but remains normal in Akita mice.…”
Section: Discussioncontrasting
confidence: 99%
“…Numerous animal studies in both chemically induced (3–8) and obese (9–11) diabetic models report that diabetes decreases cellular (3–7,9–11) and humoral immunity (3,5,8), including alloimmunity (4,7,9–11). However, confounding immune effects of streptozotocin (12,13) and disrupted leptin signaling (14) complicate interpretation of these studies.…”
Section: Introductionmentioning
confidence: 99%
“…As the present study examined the haematological indices only at 52 weeks of the treatment period and at 13 weeks following vanadyl withdrawal, with the exception of the haematocrit value, the findings obtained cannot exclude a possibility that some changes in these haematological indices may have occurred earlier in the treatment course but recover later after prolonged exposure to vanadyl sulphate. Streptozotocin-induced diabetes is known to be associated with impaired immunological function (Handwerger et al 1984). An earlier study carried out by these authors (Zaporowska & Wasilewski 1989) has shown that the changes in some selected haematological indices observed at 2 and 4 weeks after administration of ammonium metavanadate disappeared at 8 weeks.…”
Section: Parametersmentioning
confidence: 95%
“…Streptozotocin has been reported to cause mild leukopenia in mice (Schein 1969). Streptozotocin-induced diabetes is known to be associated with impaired immunological function (Handwerger et al 1984). It is not known at this stage whether the decrease in leukocyte count in the peripheral blood of untreated diabetic rats results from the residual toxic effect of streptozotocin, which was administered 1 year ago, or is related to changes in immune function associated with streptozotocin-induced diabetes.…”
Section: Parametersmentioning
confidence: 99%
“…The best evidence that insulin deficiency can alter immune function comes from restoration experiments. In fact, insulin therapy can partially or completely restore a number of the immunological abnormalities [20][21][22],…”
Section: Discussionmentioning
confidence: 99%