Considering the importance of giving continuity to economic activities that have been partially suspended by the global SARS-CoV-2 virus pandemic, the impact of virus contagions with the application of the vaccine was analyzed in Mexico City, in men and women by age groups in the second wave of the virus, from 28-June-2021 to 01-September-2021. Two Poisson regression panel models were performed by random effects by gender and age groups and the variables: infections, dose, applied vaccine, and diseases. A decrease in contagions was found with the AstraZeneca, CoronaVac, Pfizer, and Sputnik vaccines for men aged 18 to 29 years, AstraZeneca and CoronaVac for women aged 18 to 29; and AstraZeneca and Pfizer for men and women ages 50 to 59, as well as Sputnik for men and women over 60. It is concluded that COVID-19 vaccines act differently according to gender and age group. Furthermore, the vaccine that helped reduce contagions with the greatest impact was AstraZeneca for the group of 50 to 59 years old.