Nursing is a profession considered in the careers of public interest for the Ecuadorian state, it is the largest labor force in the health system and interacts with the user permanently 24 hours a day, in the physical, emotional, psychological, and spiritual areas. Nursing covers intramural and extramural spaces and develops activities of promotion, prevention, healing, and restoration of health and life in its essential competencies, direct care, and management. The proposed objective is to identify the main determinants of the performance of nursing professionals, which allows consolidating a support system for decision-making in the work and academic areas; starting from a real analysis of the situation of nursing professionals, aiming to establish the relationship of how they influence the quality of care of the users of District 02D01, to subsequently propose improvement plans. Methodology: the present investigation is a descriptive correlational transversal study applied to 146 nursing professionals and 4171 heads of the family of the 22 operative units of the district management and the Alfredo Noboa Montenegro Hospital, all corresponding to district 02D01 Guaranda Ecuador.