Factor XIIIa+ Dermal Dendrocyte Parasitism in American Tegumentary Leishmaniasis Skin Lesions

Sotto, Mírian Nacagami; Halpern, Ilana; Kauffman, M R; Pagliari, Carla

doi:10.1097/dad.0b013e3181ab4695

Cited by 9 publications

(12 citation statements)

References 27 publications

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“…Many dermatoses, both in humans and experimental models, show a strong tissue infiltration of inflammatory dendritic cells (iDCs). In American LCL lesions, an abundance of iDCs as defined by the cell marker FXIII has been reported . It has been suggested that iDCs may stimulate T cells in an antigen‐dependent manner in the skin .…”

Section: Cell‐mediated Immunity Determines Clinical Outcome In CLmentioning

confidence: 99%

Tissue damage and immunity in cutaneous leishmaniasis

Nylén

Eidsmo

2012

Parasite Immunology

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Cutaneous leishmaniasis (CL) is caused by parasitic infection of dermal macrophages resulting in intense immune-mediated tissue inflammation and skin ulceration. The severity of the disease is dependent on parasite species as well as the immune responses evoked by the host. Most cases of CL heal spontaneously. In rare cases, the ulcer/s become chronic, and some Leishmania species may induce mucosal leishmaniasis (MCL) leading to severe tissue damage. Due to difficulties in obtaining skin tissue, most human studies of CL have been limited to the analysis of peripheral blood. While systemic responses may be good correlates of immunity, tissue damage and local immune responses at the site of infection is seldom reflected in alterations in the peripheral blood. In this review, we discuss the different forms of CL focusing on the in situ responses in established disease and the mechanisms involved in pathology and healing of Leishmania infection. Great effort has been put into animal models dissecting the immune events behind the evolution of disease, tissue pathology and parasite control. These models of genetically engineered, immune deficient mice or mice given therapy prior to onset of overt disease poorly reflect the clinical situation, where patients seek treatment once infection is well established. Models of established disease are needed to address the clinical challenge of identifying new therapeutic targets in treatment CL. Through understanding immune deviations during CL potential benefits and risks of emerging biological drugs in leishmaniasis can be addressed.

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Section: Cell‐mediated Immunity Determines Clinical Outcome In CLmentioning

confidence: 99%

Tissue damage and immunity in cutaneous leishmaniasis

Nylén

Eidsmo

2012

Parasite Immunology

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“…Langerhans cells (LCs) are a population of DCs whose main function is antigen sampling and presentation in the epidermis 17 . In the dermis, an equivalent DC population, called dermal dendrocytes (DD), are as potent as LCs in antigen presentation and they have been involved in the pathogenesis of different fungal infections as paracoccidioidomycosis and chromoblastomycosis 18,19 . Curiously, LCs recognize the antigen trichophytin 20 and altered LC proliferation was associated to dermatophytosis 21 , hinting a possible role in this infection.…”

Section: Introductionmentioning

confidence: 99%

In situ immune response in human dermatophytosis: possible role of Langerhans cells (CD1a+) as a risk factor for dermatophyte infection

Reis

Correia

Jesus

et al. 2019

Rev. Inst. Med. trop. S. Paulo

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Dermatophytosis is a cutaneous mycosis caused by a plethora of keratinophilic fungi, but Trichophyton rubrum is the most common etiological agent. Despite its high prevalence worldwide, little is known about the host defense mechanisms in this infection, particularly the in situ immune response. Using an immunohistochemistry approach, we investigated the density of CD1a+, factor XIIIa+ and CD68+ cells in the skin of dermatophytosis patients. Langerhans cells (CD1a+ cells) were significantly decreased in the epidermis of patients, both in affected and unaffected areas. In the dermis, however, no differences in the density of macrophages (CD68+ cells) and dermal dendrocytes (factor XIIIa+ cells) were observed. These results suggest that the decreased number of Langerhans cells may be a risk factor for development of dermatophytosis.

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“…9,28,29 These cells are increased in quantity in several diseases such as psoriasis, 9 fibrous papule, dermatofibroma, morphea, lichen sclerosus, pyogenic granuloma, and Kaposi sarcoma. 30,31 The location of the increased amount of DDF13a around the capillaries is a noteworthy finding, suggesting a sentinel and allows us to infer that the bacillus what suggests a sentinel, strategic position of these cells, and permits inferring that the bacillus first entered the skin through dermal capillaries in our sample. Parasitism of these cells was observed in cases of American cutaneous leishmaniasis, histoid leprosy, and other infectious diseases.…”

Section: Discussionmentioning

confidence: 79%

Dermal Dendrocytes FXIIIa+ Are Essential Antigen-Presenting Cells in Indeterminate Leprosy

Lira

Pagliari

Silva

et al. 2015

The American Journal of Dermatopathology

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Indeterminate leprosy (IL) is the early phase of Hansen disease and reword (APCs). Langerhans cells and dermal dendrocytes FXIIIa positive (DDFXIIIa) are the major APCs in the skin and can be identified by the expression of CD1a and FXIIIa, respectively, by immunohistochemical techniques. Plasmacytoid dendritic cells (PDCs) are another type of dermal dendrocytes with a questionable antigen-presenting function and can be highlighted by anti-CD123 expression. To our knowledge, there are no studies evaluating DDFXIIIa and PDC in IL. The purpose was to investigate the involvement of these cells in the pathogenesis of IL. The authors performed a retrospective study on 18 cases of IL (10 confirmed and 8 suspected) to investigate expression of FXIIIa, CD1a, and CD123. The results were compared with normal skin (for CD1a and FXIIIa only). A higher amount of FXIIIa-positive cells (P , 0.05) in confirmed and suspected IL cases was noted when comparing with normal skin. However, CD1a showed no quantitative differences in the epidermis of IL lesions when comparing with normal skin and CD123 expression was negligible. Based on these findings, the authors postulate that Langerhans cells and PDCs do not have a major role in IL and that DDFXIIIa may be the main APCs in IL. Further study is required to establish this.

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Factor XIIIa+ Dermal Dendrocyte Parasitism in American Tegumentary Leishmaniasis Skin Lesions

Cited by 9 publications

References 27 publications

Tissue damage and immunity in cutaneous leishmaniasis

Tissue damage and immunity in cutaneous leishmaniasis

In situ immune response in human dermatophytosis: possible role of Langerhans cells (CD1a+) as a risk factor for dermatophyte infection

Dermal Dendrocytes FXIIIa+ Are Essential Antigen-Presenting Cells in Indeterminate Leprosy

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