Factor XI Mutation in a Holstein Cow with Repeat Breeding in Japan

Ghanem, Mohamed Elshabrawy; Nishibori, Masahide; Nakao, Toshihiko; Nakatani, Keiji; Akita, Masashi

doi:10.1292/jvms.67.713

Cited by 25 publications

(28 citation statements)

References 8 publications

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“…Furthermore, one Holstein cow with repeat breeding has been found to have the F11 deficiency heterozygous genotype in Japan [3]. However, no dams showed repeat breeding or abnormal bleeding at parturition in the F11 deficiency dams in the present study, and the rate of carriers was very high in the Japanese Black cattle.…”

Section: Discussioncontrasting

confidence: 60%

Carrier Rate of Factor XI Deficiency in Stunted Japanese Black Cattle

Watanabe

Hirano²,

Sugimoto³

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. Blood examinations and genotyping of Factor XI (F11) were performed in growth retardation Japanese Black cattle and their dams. Genotyping of F11 revealed that the recessive homozygous and heterozygous genotype frequencies were 5.2% and 50.0% in the Claudin-16 (CL-16) deficiency group (n=58), 0% and 14.2% in the renal dysplasia group (n=7), 0% and 26.1% in the non-CL-16 deficiency nephritis group (n=23), 8.9% and 46.7% in the hypogenesis syndrome group (n=45), 6.2% and 25.0% in the neonatal weak calf syndrome group (n=32), 9.1% and 38.6% in the respective dams group (n=44), 0% and 23.1% in the normal cattle group (n=13), and 5.9% and 38.2% in total (n=222), respectively. These results showed that the carrier rate of F11 deficiency was high in Japanese Black cattle, and that the CL-16 deficiency, hypogenesis syndrome, neonatal weak calf syndrome, and dams groups had a large amount of recessive homozygous genotype than the other groups. No abnormal bleeding was observed clinically in the present study, and 4 of the recessive homozygous dams showed normal growth and parturition.

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Section: Discussioncontrasting

confidence: 60%

Carrier Rate of Factor XI Deficiency in Stunted Japanese Black Cattle

Watanabe

Hirano²,

Sugimoto³

et al. 2006

The Journal of Veterinary Medical Science

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“…Therefore, it is possible that some cattle with F11 deficiency are normal. Ghanem et al (2005) reported that one Holstein cow with repeat breeding was found to have the F11 deficiency heterozygous genotype in Japan. However, no repeat breeding or abnormal bleeding at parturition has been reported in the F11 deficiency dams.…”

Section: Discussionmentioning

confidence: 99%

Economic implications of using Japanese Black sires carrying recessive genes associated with genetic defects

Nishio

Kahi

Hirooka

2008

Animal

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The objective of this study was to calculate cumulative discounted expressions (CDE) for Japanese Black sires carrying a single defective allele in a herd by applying the gene-flow method to investigate the expression pattern of homozygous recessive genotype and to evaluate the monetary loss of using these sires. A single biallelic locus was considered with A representing the dominant allele and a representing the recessive allele. The gene-flow method was modified to consider the fitness of homozygous recessive genotype. Input parameters representing a typical situation in a Japanese Black cattle herd were used to calculate the CDE and the loss of using carrier sires. The effects of initial allele frequency and fitness on the CDE were determined for Aa and AA sires. The CDE of Aa sires were larger than those of AA sires under all initial allele frequencies and fitness. The difference in the CDE between using Aa and AA sires was largest when fitness was 0 (lethal recessive condition). The differences in the loss between Aa and AA sires were larger with increasing initial allele frequencies in lethal recessive condition. Applying the method used in this study to defects reported in Japanese Black cattle and with a population size of 628 000, the difference in the loss between using Aa and AA sires was US$48 575 800 and US$74 418 000 in the case of Band-3 and Claudin-16 deficiencies, respectively. The approach used in this study could be applied to other genetic defects in different breeds and species.

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“…Holştayn sığır ırkında görülen bir nokta mutasyon, kan pıhtılaşma faktörlerinden XI yetmezliğine (FXID) neden olarak, bu M,50 bpDNA Ladder;5,homozygous control (244 bp);6,heterozygous control (244 bp,320 bp);1,2,3,4,7 ve 8 homozygous normal subjects mutasyon yönünden heterozigot bireylerde dahi döl tutma problemlerine neden olarak repeat breeder sendromunun gelişmesine etkisi olduğu bildirilmiştir (Ghanem et al 2005). Ghanem et al (2005) tarafından yapılan çalışmada, döl tutma problemi olan hayvanlar arasında FXID prevalansının % 2.5 olduğunu bildirilmiştir.…”

Section: Materyal Ve Yöntemunclassified

“…Ghanem et al (2005) tarafından yapılan çalışmada, döl tutma problemi olan hayvanlar arasında FXID prevalansının % 2.5 olduğunu bildirilmiştir. Benzer şekilde Polonya'da farklı çiftliklerden toplanan ve 28'inde repeat breeder, 9'unda ise tekrarlayan mastitis gösteren bireylerinde bulunduğu rastgele 140 baş Holştayn inek seçilerek FXID yönünden incelenmiştir.…”

Section: Materyal Ve Yöntemunclassified

“…Çalışmada incelenen repeat breeder tanısı konulmuş örneklerde FXID'e neden olan mutasyona rastlanılmamıştır. Ancak repeat breeder sendromunun gerçek sebebinin belirlenmesi çalışmalarında daha önce yapılan ve FXID ile repeat breeder sendromu arasında ilişki olabileceğini bildiren çalışmaların sonuçlarının (Ghanem et al 2005;Gurgul et …”

Section: Sonuçunclassified

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Döl tutma problemi olan holştayn ırkı sığırlarda sitogenetik ve moleküler genetik taramalar

Arslan

Özdemir

Ilgar

et al. 2016

Tarım Bilimleri Dergisi

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ÖZETSığır yetiştiriciliğinde repeat breeder sendromu olarak adlandırılan döl tutma problemi önemli bir sorundur. Holştayn ırkı sığırlarda bu problemin ortaya çıkmasında bakım-beslemenin yanı sıra Robertsonian translokasyon ve faktör XI yetmezliği (FXID) olarak adlandırılan genetik bozukluklarında rolü olduğu düşünülmektedir. Bu çalışmada Kayseri ilinde bir çiftlikte bulunan repeat breederlı Holştayn ırkı ineklerde Robertsonian translokasyon ve FXID varlığının araştırılması amaçlanmıştır. Yapılan çalışmada, repeat breeder tanısı konan 62 baş Holştayn ırkı inek incelenmiştir. Kromozomal inceleme sonucunda 62 hayvanın 58'inin normal karyotip (2n= 60 diploid), dördünün ise en sık görülen 1;29'dan farklı dört tip Robertsonian translokasyon [rob (1;21), rob (23;26), rob (24;26), rob (26;29)] profiline sahip olduğu saptanmıştır. Yapılan PCR analizi sonucunda, incelenen 62 örneğin hiçbirinde FXID'e neden olan mutasyona ait bant görüntüsü gözlenmemiştir. Çalışma sonunda, döl tutma problemi bulunan sığırlarda sitogenetik ve moleküler genetik taramaların yapılmasının kalıtsal nedenlerle gelişen repeat breeder sendromu gösteren damızlık adayların belirlenerek damızlık dışı bırakılmasına ve bu sayede özellikle damızlık yetiştiren işletmeler için çözüm yollarının aranmasına katkı sağlayacağı düşünülmüştür. ABSTRACTThe infertility problem named Repeat Breeder Syndrome is an important issue in cattle breeding. Beside maintenance and feed techniques, some genetic disorders such as Robertsonian Translocation and factor XI deficiency (FXID) are thought to be involved some problems in Holstein cattle. In this study, it was aimed to investigate the presence of Robertsonian Translocation and FXID in repeat breeder Holstein cows which grown a farm that located in the province

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Factor XI Mutation in a Holstein Cow with Repeat Breeding in Japan

Cited by 25 publications

References 8 publications

Carrier Rate of Factor XI Deficiency in Stunted Japanese Black Cattle

Carrier Rate of Factor XI Deficiency in Stunted Japanese Black Cattle

Economic implications of using Japanese Black sires carrying recessive genes associated with genetic defects

Döl tutma problemi olan holştayn ırkı sığırlarda sitogenetik ve moleküler genetik taramalar

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