Factor X deficiency and pregnancy: case report and counselling

Teixeira, Pedro Soares; Oliveira, Paulo H.; Guerra, João Carlos Campos; Hamerschlak, Nelson; Colombini, Marjorie Paris; Kalil, Renato A. K.

doi:10.1111/j.1365-2516.2011.02633.x

Cited by 5 publications

(13 citation statements)

References 4 publications

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“…The limited available data regarding the rate of PPH in women with rare bleeding disorders show that PPH is a common obstetric complication, reported in 45% of the deliveries in 10 women with congenital hypofibrinogenemia and 76% of deliveries in nine women with FV deficiency . High rates of PPH have also been reported in women with FVII, FX, FXI, and FXII deficiencies.…”

Section: Inherited Bleeding Disordersmentioning

confidence: 99%

Evaluation and management of postpartum hemorrhage: consensus from an international expert panel

et al. 2014

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Section: Inherited Bleeding Disordersmentioning

confidence: 99%

Evaluation and management of postpartum hemorrhage: consensus from an international expert panel

et al. 2014

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“…In total, 332 women were identified; 30 women in 30 case reports (Table ) and 302 women in 19 case series. In the case reports, the FX coagulant activity was <0.01 IU/mL in 14 women, 0.01‐0.05 IU/mL in 8 women and >0.05 IU/mL in four women, and in four women, the severity of FX deficiency was not mentioned . In the case series, 63 patients had FX coagulant activity ≤0.01 IU/mL, 95 patients >0.01 IU/mL (range 0.01‐0.26) and in the rest FX level was not reported.…”

Section: Resultsmentioning

confidence: 93%

“…Heavy menstrual bleeding was a common bleeding symptom reported in 72/284 (25%) in total, 14/30 (47%) in case reports, and 58/254 (23%) in 11 case series (Table ). Semi‐objective assessment of HMB in terms of pictorial blood assessment chart was not reported.…”

Section: Resultsmentioning

confidence: 97%

“…In this review, 31 pregnancies were reported in 19 women . 4/31 (13%) resulted in miscarriage and 27/31(87%) pregnancies reached viability stage (>24 weeks) . Of the latter, 8/27 (30%) pregnancies were delivered preterm (<37 weeks) and 16/27 (59%) at term (≥37 weeks) .…”

Section: Pregnancymentioning

confidence: 88%

“…In this review, 31 pregnancies were reported in 19 women . 4/31 (13%) resulted in miscarriage and 27/31(87%) pregnancies reached viability stage (>24 weeks) .…”

Section: Pregnancymentioning

confidence: 89%

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Congenital Factor X deficiency in women: A systematic review of the literature

Spiliopoulos

Kadir

2019

Haemophilia

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Factor X deficiency (FXD) is a rare autosomal recessive bleeding disorder with a variable phenotypic severity. In women, heavy menstrual bleeding (HMB), recurrent ovulation bleeding with haemoperitoneum and bleeding complications in pregnancy such as retroplacental haematoma and postpartum haemorrhage have been reported. The aim of this review was to examine gynaecological problems and obstetric complications in women with congenital FXD. A total number of 49 relevant articles were identified, including 332 women, dating from 1960 to 2018. Heavy menstrual bleeding was reported in 72/284 (25%) women in total, 14/30 (47%) in case reports and 58/254 (23%) in 11 case series, 64% and 10% required blood products and blood transfusion, respectively. Haemoperitoneum from ovulation bleeding or ruptured haemorrhagic ovarian cyst requiring blood transfusion occurred in 8/322 (2.4%) women, six required surgical intervention, including oophorectomy in two. 31 pregnancies were reported in 19 women. There were four miscarriages (including a late miscarriage at 21 weeks). There was a high rate of preterm birth and neonatal death occurring in eight (30%) and three (11%) of pregnancies reaching viability stage. Postpartum haemorrhage (PPH) occurred in six (22%) of deliveries, one requiring hysterectomy. In conclusion, women with FXD are at an increased risk of heavy bleeding during menstruation and ovulation as well as adverse pregnancy outcome and postpartum haemorrhage. Collaboration in a multidisciplinary team including an obstetrician/gynaecologist, a perinatologist and a haematologist is necessary for the prevention and management of these complications.

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Déficit congénital en facteur II

Ducloy-Bouthors¹,

Wibaut²

2015

Prise en Charge Des Maladies Rares en Anesthésie Et Analgésie Obstétricales

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Factor X deficiency and pregnancy: case report and counselling

Cited by 5 publications

References 4 publications

Evaluation and management of postpartum hemorrhage: consensus from an international expert panel

Evaluation and management of postpartum hemorrhage: consensus from an international expert panel

Congenital Factor X deficiency in women: A systematic review of the literature

Déficit congénital en facteur II

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