Factor VII-Activating Protease

Mann, Kenneth G.

doi:10.1161/01.cir.0000057382.68508.3d

Cited by 11 publications

(9 citation statements)

References 15 publications

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“…Once a sufficient clot has formed, the coagulation process is switched off, preventing excessive thrombosis. Here, platelet aggregation is inhibited by prostacylin, thrombin inhibited by antithrombin III, and coagulation factors V and VII degraded by activated protein C [ 13 ]. At the same time, the injured vessel wall is repaired by smooth muscle cells and endothelial cells that proliferate in response to released platelet-derived growth factor (PDGF) [ 14 ].…”

Section: Cellular Aspects Of Acute Wound Repairmentioning

confidence: 99%

Wound healing: cellular mechanisms and pathological outcomes

2020

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Wound healing is a complex, dynamic process supported by a myriad of cellular events that must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound-linked cellular behaviours, as occurs with diabetes and ageing, can lead to healing impairment and the formation of chronic, non-healing wounds. These wounds are a significant socioeconomic burden due to their high prevalence and recurrence. Thus, there is an urgent requirement for the improved biological and clinical understanding of the mechanisms that underpin wound repair. Here, we review the cellular basis of tissue repair and discuss how current and emerging understanding of wound pathology could inform future development of efficacious wound therapies.

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Section: Cellular Aspects Of Acute Wound Repairmentioning

confidence: 99%

Wound healing: cellular mechanisms and pathological outcomes

2020

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“…23 After proper clot formation, excess platelet aggregation is inhibited by prostacyclin. Furthermore, thrombin is inhibited by antithrombin, and coagulation factors V and VII are degraded by the protein C. 24 Inflammatory phase. Innate immunity initiates the interaction between necrotic tissue damage-associated molecular patterns (DAMPs) and the self-molecules however, pathogen-associated molecular patterns (PAMPs) interact with the pathogen proteins or nucleic acids, which confirms the presence of foreign invaders.…”

Section: Wound Healing Phasesmentioning

confidence: 99%

“…23 After proper clot formation, excess platelet aggregation is inhibited by prostacyclin. Furthermore, thrombin is inhibited by anti-thrombin, and coagulation factors V and VII are degraded by the protein C. 24…”

Section: Interplay Of Immune Cells In the Wound Environmentmentioning

confidence: 99%

Biomaterial mediated immunomodulation: An interplay of material environment interaction for ameliorating wound regeneration

et al. 2023

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Chronic wounds are the outcome of an imbalanced inflammatory response caused by sustenance of immune microenvironment. In this context, tissue engineered graft played great role in healing wounds but faced difficulty in scar remodelling, immune rejection and poor vascularization. All the limitations faced are somewhere linked with the immune cells involved in healing. In this consideration, immunomodulatory biomaterials bridge a large gap with the delivery of modulating factors for triggering key inflammatory cells responsible towards interplay in the wound micro-environment. Inherent physico-chemical properties of biomaterials substantially determine the nature of cell-materials interaction thereby facilitating differential cytokine gradient involved in activation or suppression of inflammatory signalling pathways, and followed by surface marker expression. This review aims to systematically describe the interplay of immune cells involved in different phases in the wound microenvironment and biomaterials. Additionally, it also focuses on modulating innate immune cell responses in the context of triggering the halted phase of the wound healing, i.e., inflammatory phase. The various strategies are highlighted for modulation of wound microenvironment towards wound regeneration including stem cells, cytokines, growth factors, vitamins, and anti-inflammatory agents to induce interactive ability of biomaterials with immune cells. The last section focuses on prospective approaches and current potential strategies for wound regeneration. This includes the development of different models to bridge the gap between mouse models and human patients. Emerging new tools to study inflammatory response owing to biomaterials and novel strategies for modulation of monocyte and macrophage behaviour in the wound environment are also discussed.

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“…The platelet aggregate (platelet plug) physically seals the breaks in the blood vessel to prevent blood outflow; this is termed primary hemostasis. 6,7 Aggregated platelets secrete several growth factors and chemokines to attract various cell types (fibroblasts and inflammatory cells) to initiate the healing process. The growth factors include platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), insulin-like growth factor-1 (IGF-1), transforming growth factor alpha (TGF-α), and vascular endothelial growth factor (VEGF).…”

Section: Introductionmentioning

confidence: 99%

“…The coagulation cascade is initiated to form a fibrin mesh that can strengthen the platelet plug and form a stable clot. 6,7 A coagulation cascade is a sequential activation of a series of clotting factors in a multistep pathway. The coagulation cascade can be triggered by two different pathways: extrinsic and intrinsic, as shown in Figure 2c.…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin and Its Nanocomposites for Wound Care: A Comprehensive Review

Indrakumar,

Dash,

Mishra

et al. 2024

ACS Polym. Au

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For most individuals, wound healing is a highly organized, straightforward process, wherein the body transitions through different phases in a timely manner. However, there are instances where external intervention becomes necessary to support and facilitate different phases of the body's innate healing mechanism. Furthermore, in developing countries, the cost of the intervention significantly impacts access to treatment options as affordability becomes a determining factor. This is particularly true in cases of long-term wound treatment and management, such as chronic wounds and infections. Silk fibroin (SF) and its nanocomposites have emerged as promising biomaterials with potent wound-healing activity. Driven by this motivation, this Review presents a critical overview of the recent advancements in different aspects of wound care using SF and SF-based nanocomposites. In this context, we explore various formats of hemostats and assess their suitability for different bleeding situations. The subsequent sections discuss the primary causes of nonhealing wounds, i.e., prolonged inflammation and infections. Herein, different treatment strategies to achieve immunomodulatory and antibacterial properties in a wound dressing were reviewed. Despite exhibiting excellent pro-healing properties, few silk-based products reach the market. This Review concludes by highlighting the bottlenecks in translating silk-based products into the market and the prospects for the future.

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Factor VII-Activating Protease

Cited by 11 publications

References 15 publications

Wound healing: cellular mechanisms and pathological outcomes

Wound healing: cellular mechanisms and pathological outcomes

Biomaterial mediated immunomodulation: An interplay of material environment interaction for ameliorating wound regeneration

Silk Fibroin and Its Nanocomposites for Wound Care: A Comprehensive Review

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