Wound healing: cellular mechanisms and pathological outcomes

Wilkinson, Holly N.; Hardman, Matthew J.

doi:10.1098/rsob.200223

Cited by 792 publications

(792 citation statements)

References 225 publications

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“…This initiates inflammatory processes through the activation of NF-κB. Otherwise, this protective immune response is an inescapable entailment of tissue damage and uncontrolled inflammation negatively regulates the tissue renewal after injuries and delays the healing mechanisms [ 3 , 4 , 55 , 60 ]. However, following tissue damages, the inflammatory response is a normal process and facilitates the repair by recruiting innate immune cells [ 4 ].…”

Section: Resultsmentioning

confidence: 99%

“…Otherwise in the skin, a plethora of examinations bear out that AMPs participate in modulating the immune response (e.g., cytokine production, cell proliferation, etc.) and enhancing the healing process [ 60 , 68 ]. Similar findings were described among invertebrates (e.g., D. melanogaster , Caenorhabditis elegans ) highlighting that wound healing after tissue injury is conserved progress on an evolutionary scale [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

“…Otherwise in the skin, a plethora of examinations bear out that AMPs participate in modulating the immune response (e.g., cytokine production, cell proliferation, etc.) and enhancing the healing process [60,68]. Sim- Interestingly, genes responsible for pro-and anti-inflammatory peptides became overregulated in the early restoration of Xenopus larval hindlimb that may be necessary for determining the quality of regeneration [65].…”

Section: Lysenin Proteins Are Inversely Secreted During Anterior Vsmentioning

confidence: 99%

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Injury-Induced Innate Immune Response During Segment Regeneration of the Earthworm, Eisenia andrei

Bodó

Kellermayer

László

et al. 2021

IJMS

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Regeneration of body parts and their interaction with the immune response is a poorly understood aspect of earthworm biology. Consequently, we aimed to study the mechanisms of innate immunity during regeneration in Eisenia andrei earthworms. In the course of anterior and posterior regeneration, we documented the kinetical aspects of segment restoration by histochemistry. Cell proliferation peaked at two weeks and remitted by four weeks in regenerating earthworms. Apoptotic cells were present throughout the cell renewal period. Distinct immune cell (e.g., coelomocyte) subsets were accumulated in the newly-formed blastema in the close proximity of the apoptotic area. Regenerating earthworms have decreased pattern recognition receptors (PRRs) (e.g., TLR, except for scavenger receptor) and antimicrobial peptides (AMPs) (e.g., lysenin) mRNA patterns compared to intact earthworms. In contrast, at the protein level, mirroring regulation of lysenins became evident. Experimental coelomocyte depletion caused significantly impaired cell divisions and blastema formation during anterior and posterior regeneration. These obtained novel data allow us to gain insight into the intricate interactions of regeneration and invertebrate innate immunity.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Otherwise in the skin, a plethora of examinations bear out that AMPs participate in modulating the immune response (e.g., cytokine production, cell proliferation, etc.) and enhancing the healing process [60,68]. Sim- Interestingly, genes responsible for pro-and anti-inflammatory peptides became overregulated in the early restoration of Xenopus larval hindlimb that may be necessary for determining the quality of regeneration [65].…”

Section: Lysenin Proteins Are Inversely Secreted During Anterior Vsmentioning

confidence: 99%

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Injury-Induced Innate Immune Response During Segment Regeneration of the Earthworm, Eisenia andrei

Bodó

Kellermayer

László

et al. 2021

IJMS

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“…( D ) Remodeling phase causes the wound contraction that initiated by fibroblasts and myofibroblasts. Adapted with permission [ 8 ]. Licensed under CC BY 4.0.…”

Section: Figurementioning

confidence: 99%

The In Vivo, In Vitro and In Ovo Evaluation of Quantum Dots in Wound Healing: A Review

Salleh

2021

Polymers

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Wound is defined as primarily damaged or disruption of skin contributed to the loss of its microstructure stability and which undergoes complex wound healing process. However, there are tons of factors that could affect the wound healing process such as infection and slow angiogenesis. Involvement of nanotechnologies therapies in wound care research aims to facilitates this healing process. Quantum dots (QDs) are an advanced nanomaterial technology found to be useful in clinical and biomedical applications. This review has been carried out to provide a summary of the application of QDs in acute or chronic wound healing. A thorough searching was done via Web of Science and SCOPUS database to obtain relevant articles including the in vivo, in vitro and in ovo studies. The results demonstrated a similar effect of different types of QDs, or an improvement of QDs in wound healing, antibacterial and angiogenesis properties. This review demonstrated the effectiveness of QDs for the wound healing process mainly by their antibacterial activity. Uniquely, the antibacterial effect unraveled an increasing trend over time influenced by the various concentration of QDs. In conclusion, the application of QDs support the wound healing phases and proven to be effective in vivo, in vitro and in ovo. However, the future QDs work should focus on the molecular level for the details of cellular interactions and pathways.

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“…In this phase, the blood vessel will immediately undergo vasoconstriction to prevent blood loss followed by primary and secondary hemostasis [ 25 ]. Primary hemostasis stimulates platelet aggregation to the injury site and interacts with the ECM protein components such as fibronectin, collagen, and factor VIII [ 27 ]. Secondary hemostasis will activate the coagulation cascade in which fibrinogen will be converted, forming a fibrin mesh at the injury site to trap red blood cells, and hence stopping the bleeding [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Current Insight of Printability Quality Improvement Strategies in Natural-Based Bioinks for Skin Regeneration and Wound Healing

Masri

2021

Polymers

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Skin tissue engineering aimed to replace chronic tissue injury commonly occurred due to severe burn and chronic wound in diabetic ulcer patients. The normal skin is unable to be regenerated until the seriously injured tissue is disrupted and losing its function. 3D-bioprinting has been one of the effective methods for scaffold fabrication and is proven to replace the conventional method, which reported several drawbacks. In light of this, researchers have developed a new fabrication approach via 3D-bioprinting by combining biomaterials (bioinks) with cells and biomolecules followed by a suitable crosslinking approach. This advanced technology has been subcategorised into three different printing techniques including inject-based, laser-based, and extrusion-based printing. However, the printable quality of the currently available bioinks demonstrated shortcomings in the physicochemical and mechanical properties. This review aims to identify the limitations raised by using natural-based bioinks and the optimum temperature for various applied printing techniques. It is essential to ensure maintaining the acceptable printed scaffold property such as the optimum pore sizes and porosity that allow cell migration activity. In addition, the properties required for an ideal bioinks design for better scaffold printability were also summarised.

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Wound healing: cellular mechanisms and pathological outcomes

Cited by 792 publications

References 225 publications

Injury-Induced Innate Immune Response During Segment Regeneration of the Earthworm, Eisenia andrei

Injury-Induced Innate Immune Response During Segment Regeneration of the Earthworm, Eisenia andrei

The In Vivo, In Vitro and In Ovo Evaluation of Quantum Dots in Wound Healing: A Review

Current Insight of Printability Quality Improvement Strategies in Natural-Based Bioinks for Skin Regeneration and Wound Healing

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